3-day-old miniature piglets were stimulated in vivo with Bacillus firmus by the intraperitoneal or intragastric route for 1 d. Cells containing IgA and IgG2 were detected in the ileum in all stimulated but not in control animals. The frequency of blood CD3+ cells increased after intraperitoneal administration of B. firmus, the ratio of polymorphonuclears to lymphocytes increased in all stimulated piglets. B. firmus induced antitumor immunity in rats with transplanted Yoshida sarcoma cells. Granular lymphocytes and dead tumor cells were found in peritoneal exudate of stimulated animals. B. firmus induced IFN-gamma synthesis in human blood lymphocytes stimulated in vitro for 1 d. The amount of TNF-alpha produced by these stimulated human peripheral blood mononuclears (PBMC) was lower than that of PBMC stimulated with some other bacterial immunomodulators. Cells containing TGF-beta or IL-8 were not found in human PBMC stimulated with B. firmus.

• MeSH
• Adjuvants, Immunologic pharmacology   therapeutic use   MeSH
• Bacillus immunology   MeSH
• Bacterial Vaccines pharmacology   therapeutic use   MeSH
• Intubation, Gastrointestinal MeSH
• Ileum immunology   MeSH
• Immunoglobulin A biosynthesis   MeSH
• Immunoglobulin G biosynthesis   MeSH
• Immunotherapy * MeSH
• Injections, Intraperitoneal MeSH
• Interferon-gamma biosynthesis   MeSH
• Rats MeSH
• Cells, Cultured MeSH
• Leukocytes, Mononuclear drug effects   metabolism   MeSH
• Humans MeSH
• Swine, Miniature MeSH
• Rats, Wistar MeSH
• Swine MeSH
• Sarcoma, Yoshida therapy   MeSH
• Tumor Necrosis Factor-alpha biosynthesis   MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Adjuvants, Immunologic MeSH
• Bacterial Vaccines MeSH
• Immunoglobulin A MeSH
• Immunoglobulin G MeSH
• Interferon-gamma MeSH
• Tumor Necrosis Factor-alpha MeSH