Immunomodulatory effects of Bacillus firmus
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
9449788
DOI
10.1007/bf02816958
Knihovny.cz E-zdroje
- MeSH
- adjuvancia imunologická farmakologie terapeutické užití MeSH
- Bacillus imunologie MeSH
- bakteriální vakcíny farmakologie terapeutické užití MeSH
- gastrointestinální intubace MeSH
- ileum imunologie MeSH
- imunoglobulin A biosyntéza MeSH
- imunoglobulin G biosyntéza MeSH
- imunoterapie * MeSH
- injekce intraperitoneální MeSH
- interferon gama biosyntéza MeSH
- krysa rodu Rattus MeSH
- kultivované buňky MeSH
- leukocyty mononukleární účinky léků metabolismus MeSH
- lidé MeSH
- miniaturní prasata MeSH
- potkani Wistar MeSH
- prasata MeSH
- sarkom Yoshidův terapie MeSH
- TNF-alfa biosyntéza MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adjuvancia imunologická MeSH
- bakteriální vakcíny MeSH
- imunoglobulin A MeSH
- imunoglobulin G MeSH
- interferon gama MeSH
- TNF-alfa MeSH
3-day-old miniature piglets were stimulated in vivo with Bacillus firmus by the intraperitoneal or intragastric route for 1 d. Cells containing IgA and IgG2 were detected in the ileum in all stimulated but not in control animals. The frequency of blood CD3+ cells increased after intraperitoneal administration of B. firmus, the ratio of polymorphonuclears to lymphocytes increased in all stimulated piglets. B. firmus induced antitumor immunity in rats with transplanted Yoshida sarcoma cells. Granular lymphocytes and dead tumor cells were found in peritoneal exudate of stimulated animals. B. firmus induced IFN-gamma synthesis in human blood lymphocytes stimulated in vitro for 1 d. The amount of TNF-alpha produced by these stimulated human peripheral blood mononuclears (PBMC) was lower than that of PBMC stimulated with some other bacterial immunomodulators. Cells containing TGF-beta or IL-8 were not found in human PBMC stimulated with B. firmus.
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