Differential effect of Bacillus firmus on immune response and enterocyte brush-border enzyme levels in BALB/c and B10.BR mice
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
12630333
DOI
10.1007/bf02818685
Knihovny.cz E-zdroje
- MeSH
- alkalická fosfatasa metabolismus MeSH
- Bacillus imunologie MeSH
- beta-galaktosidasa metabolismus MeSH
- dipeptidylpeptidasa 4 metabolismus MeSH
- enterocyty enzymologie mikrobiologie MeSH
- genetická predispozice k nemoci MeSH
- glukoamylasa metabolismus MeSH
- gnotobiologické modely MeSH
- imunoglobulin A biosyntéza krev MeSH
- imunohistochemie MeSH
- laktasa MeSH
- mikroklky enzymologie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- sacharasa metabolismus MeSH
- střeva enzymologie imunologie mikrobiologie MeSH
- střevní sliznice enzymologie imunologie mikrobiologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- alkalická fosfatasa MeSH
- beta-galaktosidasa MeSH
- dipeptidylpeptidasa 4 MeSH
- glukoamylasa MeSH
- imunoglobulin A MeSH
- laktasa MeSH
- sacharasa MeSH
A nonpathogenic bacterium of external environment possessing remarkable immunomodulatory activity, Bacillus firmus (BF) inactivated with formaldehyde, was given intragastrically to two genetically different mouse strains BALB/c (H-2d) and B10.BR/SnPh (B10.BR, H-2k) reared in conventional (CV) and B10.BR strain also in germ-free (GF) conditions. Repeated intragastric administration of BF (500 micrograms every other day over two weeks, starting at the age of 3 months) significantly enhanced intestinal IgA levels in CV BALB/c mice but did not affect intestinal IgA in CV B10.BR mice. In GF B10.BR mice, IgG levels in sera and intestinal washings increased after BF administration compared to CV B10.BR mice. In CV BALB/c mice, specific activity of enterocyte brush-border enzymes (lactase, gamma-glutamyltransferase, alkaline phosphatase) decreased after BF treatment; sucrase (sucrose alpha-glucosidase) activity was not affected. On the other hand, in B10.BR mice, specific activity of gamma-glutamyltransferase and dipeptidyl peptidase IV were higher after administration of BF in both CV and GF groups relative to untreated controls. The activities of lactase and glucoamylase (glucan 1,4-alpha-glucosidase) were significantly stimulated only in the group of GF B10.BR mice treated with formolized BF. The stimulation of immunoglobulin production after BF treatment was accompanied by changes in the levels of enterocyte brush-border enzymes; this responsiveness to BF treatment was genetically regulated.
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