Effect of crude bacterial lipids on the course of Listeria infection in mice
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
1296929
DOI
10.1007/bf02899905
Knihovny.cz E-zdroje
- MeSH
- adjuvancia imunologická izolace a purifikace farmakologie MeSH
- Bacillus imunologie MeSH
- Bacteria chemie imunologie MeSH
- Enterobacteriaceae imunologie MeSH
- grampozitivní bakterie imunologie MeSH
- lipidy imunologie izolace a purifikace farmakologie MeSH
- Listeria imunologie MeSH
- listeriové infekce imunologie terapie MeSH
- myši MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adjuvancia imunologická MeSH
- lipidy MeSH
Crude lipids from 37 strains belonging to 32 bacterial species were isolated. By injecting mice with lipids 5 d prior to challenge with a virulent strain of Listeria monocytogenes, immunostimulatory activity in 19 preparations was found. In general, lipids of Gram-negative bacteria appeared to be more effective. As to bacilli, an extraordinary activity was found in the lipids of Bacillus firmus. Lipids of various species of the genus Listeria were found to be active in approximately one-half of cases. Among other Gram-positive bacteria, significant activity of lipids was found in Corynebacterium xerosis, Propionibacterium acnes and BCG. The composition of fatty acids in the lipids did not differ significantly from that reported in the literature and their mutual differences could not explain the different biological activity. In selected strains of Gram-negative bacteria lipids were repeatedly purified with anhydrous chloroform; these preparations were found to be inactive as compared with original chloroform-methanol lipids.
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