• Klíčová slova
• anti‐CTLA‐4, anti‐PD‐1, lenvatinib, metastatic melanoma, pembrolizumab, pretreated patients,
• Publikační typ
• dopisy MeSH

• MeSH
• akrodermatitida * farmakoterapie   MeSH
• lidé MeSH
• monoklonální protilátky terapeutické užití   MeSH
• psoriáza * farmakoterapie   MeSH
• vezikulobulózní nemoci kůže * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• dopisy MeSH
• Názvy látek
• monoklonální protilátky MeSH
• risankizumab MeSH Prohlížeč

• MeSH
• adalimumab farmakologie   terapeutické užití   MeSH
• dermatologické látky farmakologie   terapeutické užití   MeSH
• hidradenitis suppurativa diagnóza   farmakoterapie   imunologie   MeSH
• humanizované monoklonální protilátky farmakologie   terapeutické užití   MeSH
• hýždě MeSH
• interleukin-17 imunologie   metabolismus   MeSH
• léková rezistence MeSH
• lidé středního věku MeSH
• lidé MeSH
• receptory interleukinu-17 antagonisté a inhibitory   metabolismus   MeSH
• stupeň závažnosti nemoci MeSH
• TNF-alfa antagonisté a inhibitory   imunologie   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• adalimumab MeSH
• brodalumab MeSH Prohlížeč
• dermatologické látky MeSH
• humanizované monoklonální protilátky MeSH
• IL17RA protein, human MeSH Prohlížeč
• interleukin-17 MeSH
• receptory interleukinu-17 MeSH
• TNF protein, human MeSH Prohlížeč
• TNF-alfa MeSH

BACKGROUND: BIOREP is a Czech registry of psoriatic patients on biological treatment in a clinical setting. We describe the characteristics of patients with psoriasis at the time of enrollment and present comparisons with published data from other national registries. METHODS: We analyzed the cohort of patients treated with biologics between May 2005 and May 2015. Demographic data, previous therapies, comorbidities, and severity of psoriasis were compared with data from other registries - DERMBIO, BIOBADADERM, BADBIR, and PSOBEST. RESULTS: A total of 1412 psoriatic patients initiating biological treatment were included with a predominance of males (63.4%). The mean patient age was 50.2 years, and approximately 70.5% of patients were either overweight or obese. The mean baseline Psoriasis Area and Severity Index was 19.8, and the Dermatology Life Quality Index was 16.6. More than one-third of patients (41.0%) reported a history of psoriatic arthritis, and a high proportion of patients (49.5%) with cardiovascular risk factors (hypertension [35.2%], hyperlipidemia [27.7%], diabetes mellitus [11.4%], coronary heart disease [4.9%], and obesity [15.2%]) were observed. Most of the patients had been previously treated with phototherapy (85.4%), acitretin (74.0%), methotrexate (65.7%), or cyclosporine (53.1%). CONCLUSION: BIOREP is one of the first registries of patients with psoriasis treated with biologics in Central and Eastern Europe. Our results found a similar or higher prevalence of comorbidities, long disease duration, and high impact on the quality of life among patients included in Western European registries.

• MeSH
• acitretin terapeutické užití   MeSH
• biologické přípravky terapeutické užití   MeSH
• cyklosporin terapeutické užití   MeSH
• dermatologické látky terapeutické užití   MeSH
• diabetes mellitus epidemiologie   MeSH
• dospělí MeSH
• fototerapie MeSH
• hyperlipidemie epidemiologie   MeSH
• hypertenze epidemiologie   MeSH
• index tělesné hmotnosti MeSH
• keratolytika terapeutické užití   MeSH
• komorbidita MeSH
• koronární nemoc epidemiologie   MeSH
• kvalita života MeSH
• lidé středního věku MeSH
• lidé MeSH
• methotrexát terapeutické užití   MeSH
• obezita epidemiologie   MeSH
• opakovaná terapie MeSH
• prevalence MeSH
• psoriáza farmakoterapie   epidemiologie   terapie   MeSH
• registrace MeSH
• retrospektivní studie MeSH
• rizikové faktory MeSH
• stupeň závažnosti nemoci MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Názvy látek
• acitretin MeSH
• biologické přípravky MeSH
• cyklosporin MeSH
• dermatologické látky MeSH
• keratolytika MeSH
• methotrexát MeSH

BACKGROUND: Toll-like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T-cell driven immune-mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to assess both the kinetics of the expression of TLR2 on blood cells and the concentration of soluble (s)TLR2 in serum of patients with psoriasis and to examine the effect of GT on both TLR2 expression and sTLR2 level. METHODS: Both membrane and sTLR2 were determined in 20 patients and 20 healthy controls. sTLR2 was evaluated by enzyme-linked immunosorbent assay. Flow cytometry method was used to determine the expression of membrane TLR2 of monocytes and granulocytes. RESULTS: The serum level of sTLR2 was significantly lower (P < 0.0001) in patients both before and after GT compared to the control group. Compared to the membrane expression of TLR2 on monocytes of healthy blood donors, TLR2 expression was significantly higher in patients both before and after GT (P = 0.0001). Similarly, TLR2 expression on granulocytes was significantly higher in patients both before (P = 0.0061) and after (P < 0.0001) therapy than in control. CONCLUSIONS: Membrane and soluble TLR2 may be involved in the pathogenesis of psoriasis. Both remained unchanged by GT.

• MeSH
• buněčná membrána chemie   MeSH
• dehet uhelný terapeutické užití   MeSH
• dospělí MeSH
• fotochemoterapie * MeSH
• granulocyty chemie   MeSH
• keratolytika terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• monocyty chemie   MeSH
• psoriáza krev   farmakoterapie   MeSH
• studie případů a kontrol MeSH
• terapie ultrafialovými paprsky * MeSH
• toll-like receptor 2 analýza   krev   MeSH
• zdraví dobrovolníci pro lékařské studie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• dehet uhelný MeSH
• keratolytika MeSH
• TLR2 protein, human MeSH Prohlížeč
• toll-like receptor 2 MeSH

• MeSH
• dermatitida etiologie   patologie   MeSH
• houby šii-take chemie   MeSH
• kůže patologie   MeSH
• lentinan škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• potravinová alergie etiologie   patologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• dopisy MeSH
• kazuistiky MeSH
• Názvy látek
• lentinan MeSH

BACKGROUND: The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1 333 a/b, TAP1 637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF]α [-238 G/A] and NcoI TNFβ) with characteristics of family history in patients with psoriasis vulgaris. MATERIALS AND METHODS: A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNFα, and TNFβ genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. RESULTS: We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (Pa = 0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism. As for the TNFα (-238 G/A) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second- and third-degree relatives with psoriasis (Pg = 0.008). Similarly, the B2B2 genotype of NcoI TNFβ polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis (Pg = 0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bcCB1A was different between not only men and women with psoriasis (P = 0.007) but also between men and women without a family history of psoriasis (P = 0.007). CONCLUSIONS: Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.

• MeSH
• ABC transportéry genetika   MeSH
• dospělí MeSH
• genetická predispozice k nemoci epidemiologie   genetika   MeSH
• haplotypy MeSH
• HLA-DRB1 řetězec genetika   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lymfotoxin-alfa genetika   MeSH
• peptidový transportér TAP1 MeSH
• polymorfismus délky restrikčních fragmentů MeSH
• polymorfismus genetický MeSH
• psoriáza epidemiologie   genetika   MeSH
• rizikové faktory MeSH
• senioři MeSH
• TNF-alfa genetika   MeSH
• zdraví rodiny MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• ABC transportéry MeSH
• HLA-DRB1 řetězec MeSH
• HLA-DRB1*15:01 antigen MeSH Prohlížeč
• lymfotoxin-alfa MeSH
• peptidový transportér TAP1 MeSH
• TAP1 protein, human MeSH Prohlížeč
• TNF-alfa MeSH

BACKGROUND: Depression and mood changes appear as potentional side effects of isotretinoin in the Summary of Product Characteristics. There have been many studies treating this topic but in most cases not identifying any significant depression or suicide risk. To further investigate this issue, we conducted a prospective, uncontrolled study to evaluate mood changes and suicidal ideations in patients receiving isotretinoin therapy. METHODS: One-hundred patients were included in our single center, no-blind, and no controlled prospective study. All patients completed the Beck's Depression Inventory, Version II (BDI-II) before the treatment, following the first month of the treatment and then every third month until finishing the isotretinoin therapy. All questionnaires were checked by a psychiatrist. Suicidal ideations were monitored. Statistical analysis of BDI-II scores was performed. RESULTS: All patients completed the study. Before the treatment, six percent of the patients had suffered from depressive symptoms. During the isotretinoin treatment, we did not find any deterioration of depression problems in any of these patients. On the contrary, in most patients the depressive symptoms disappeared. Symptoms of depression occurred in two patients, in which case coexisting situational factors were found to be the cause. No occurrence of suicidal ideations was found. CONCLUSIONS: We did not find any depressive symptoms or suicide risk caused by isotretinoin. On the contrary, a statistically significant improvement of BDI-II scores was found. In our opinion, patients have to be informed about the risk of depression but emphasizing the fact that it is very rare.

• MeSH
• acne vulgaris farmakoterapie   psychologie   MeSH
• afektivní symptomy chemicky indukované   epidemiologie   MeSH
• depresivní poruchy chemicky indukované   epidemiologie   MeSH
• dermatologické látky aplikace a dávkování   škodlivé účinky   MeSH
• dítě MeSH
• dospělí MeSH
• isotretinoin aplikace a dávkování   škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• následné studie MeSH
• poruchy nálady chemicky indukované   epidemiologie   MeSH
• prospektivní studie MeSH
• průzkumy a dotazníky MeSH
• psychologické testy MeSH
• rizikové faktory MeSH
• sebevražedné myšlenky * MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• Názvy látek
• dermatologické látky MeSH
• isotretinoin MeSH

BACKGROUND: Atopic dermatitis (AD) still remains one of the most common childhood inflammatory skin diseases. As a chronic disease, it can have a physical and psychological effect on social functioning of the affected child as well as their family. The objective of this study was to evaluate the quality of life of children with AD of different age groups and their families. METHODS: A total of 203 children with a diagnosis of AD from newborn to 18 years of age and 202 of their parents took part in our study (as one parent did not return the questionnaire). All participants, according to their age, completed the following questionnaires: Infants' Dermatitis Quality of Life Index (IDQOL); Children's Dermatology Life Quality Index (CDLQI) - text and cartoon version; and Dermatitis Family Impact questionnaire (DFI). RESULTS: The mean total IDQOL score in our study was 8.18 (SD = 5.84, n = 120). The mean total CDLQI scores in the groups of children from 7 to 13 and from 14 to 18 years were 8.58 (SD = 4.98, n = 48) and 9.89 (SD = 5.26, n = 35). There was also a proven influence of the child's AD on the quality of life of his parents with the mean score: 7.98 (SD = 6.41, n = 202). CONCLUSIONS: The study demonstrated and confirmed that AD significantly impairs the children's quality of life in all age groups and also quality of life of their families. Such data give us patient-oriented information that is of great importance for understanding the situation of individuals with AD and its influence on members of their family.

• MeSH
• analýza rozptylu MeSH
• atopická dermatitida psychologie   MeSH
• dítě MeSH
• kojenec MeSH
• kvalita života * MeSH
• lidé MeSH
• mladiství MeSH
• novorozenec MeSH
• předškolní dítě MeSH
• průzkumy a dotazníky MeSH
• rodiče MeSH
• Check Tag
• dítě MeSH
• kojenec MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• novorozenec MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

• MeSH
• dějiny 21. století MeSH
• dermatologie * dějiny   MeSH
• odměny a ceny * MeSH
• školy lékařské MeSH
• Check Tag
• dějiny 21. století MeSH
• Publikační typ
• biografie MeSH
• historické články MeSH
• portréty MeSH
• zprávy MeSH
• Geografické názvy
• Česká republika MeSH
• Čína MeSH
• Itálie MeSH

• O autorovi
• Hercogová, Jana
• Lotti, Torello