Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23834030
DOI
10.1111/ijd.12213
Knihovny.cz E-resources
- MeSH
- ATP-Binding Cassette Transporters genetics MeSH
- Adult MeSH
- Genetic Predisposition to Disease epidemiology genetics MeSH
- Haplotypes MeSH
- HLA-DRB1 Chains genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphotoxin-alpha genetics MeSH
- ATP Binding Cassette Transporter, Subfamily B, Member 2 MeSH
- Polymorphism, Restriction Fragment Length MeSH
- Polymorphism, Genetic MeSH
- Psoriasis epidemiology genetics MeSH
- Risk Factors MeSH
- Aged MeSH
- Tumor Necrosis Factor-alpha genetics MeSH
- Family Health MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ATP-Binding Cassette Transporters MeSH
- HLA-DRB1 Chains MeSH
- HLA-DRB1*15:01 antigen MeSH Browser
- Lymphotoxin-alpha MeSH
- ATP Binding Cassette Transporter, Subfamily B, Member 2 MeSH
- TAP1 protein, human MeSH Browser
- Tumor Necrosis Factor-alpha MeSH
BACKGROUND: The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1 333 a/b, TAP1 637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF]α [-238 G/A] and NcoI TNFβ) with characteristics of family history in patients with psoriasis vulgaris. MATERIALS AND METHODS: A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNFα, and TNFβ genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. RESULTS: We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (Pa = 0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism. As for the TNFα (-238 G/A) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second- and third-degree relatives with psoriasis (Pg = 0.008). Similarly, the B2B2 genotype of NcoI TNFβ polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis (Pg = 0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bcCB1A was different between not only men and women with psoriasis (P = 0.007) but also between men and women without a family history of psoriasis (P = 0.007). CONCLUSIONS: Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.
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