We present here ultrastructural findings in three composite tumours having giant cell fibroblastoma--dermatofibrosarcoma protuberans components occurring in adult patients. We further hypothesize that these 3 tumours belong to the group of neoplasms that can show giant cell fibroblastoma, dermatofibrosarcoma protuberans, dendritic pigment cell, myxoid, and fibrosarcomatous differentiation. We consider the giant cell fibroblastoma areas of the tumours to represent a well-differentiated component of these neoplasms.

• MeSH
• buněčné jádro patologie   ultrastruktura   MeSH
• dermatofibrosarkom patologie   ultrastruktura   MeSH
• dospělí MeSH
• elektronová mikroskopie MeSH
• fibrom patologie   ultrastruktura   MeSH
• lidé MeSH
• melaniny analýza   MeSH
• nádory kůže patologie   ultrastruktura   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• melaniny MeSH

In 10 cases of senile dementia of Alzheimer's type (AD) a systematic post-mortem ultrastructural analysis was performed. Attention was paid mainly to the presence of autolysosomes in the neuropil of the brain cortex. Autolysosomes appeared as osmiophilic dense bodies (DB) which originated in synaptic terminals and peripheral nerve-cell processes. DBs contained sequestrated cellular material wrapped by pinched off, invaginated cell membrane. DB were very frequent also in fields where no senile plaques (SP) and/or nerve-cell processes with paired helical filaments (PHF) were present. Abnormal fermentative degradation of DBs and their possible negative influence on the plasmatic flow in nerve-cell processes is discussed.

• MeSH
• Alzheimerova nemoc patologie   MeSH
• axony patologie   ultrastruktura   MeSH
• elektronová mikroskopie MeSH
• lidé MeSH
• lyzozomy patologie   ultrastruktura   MeSH
• mozková kůra patologie   ultrastruktura   MeSH
• nervová zakončení patologie   ultrastruktura   MeSH
• pitva MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• synapse patologie   ultrastruktura   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

We describe a case of a 48 year old man who presented repeatedly with a neck lymph node tumor. The tumor grew insidiously over 11 years and the patient died at the age of 58 with the generalization of the tumor into the right cervical, paratracheal lymph nodes and spleen. The tumor was composed of spindle shaped cells with occasional intranuclear cytoplasmic pseudoinclusion. At the ultrastructural level the tumor revealed membrane bound crystalline inclusions, which were locally in direct contact with both the nuclear envelope and confronting cisternae of the endoplasmic reticulum. The tumor was associated with multiclonal gammopathy composed of two subsets of IgG/lambda and one subset of IgA/lambda positive paraprotein produced by lymphoid cells surrounding the tumor. We diagnosed the tumor as "spindle cell tumor of lymph node of probable reticulum cell origin associated with multiclonal gammopathy" and consider the lymphoid tissue producing the paraprotein to be reactive.

• MeSH
• imunoglobulin A analýza   MeSH
• imunoglobulin G analýza   MeSH
• imunoglobuliny - lambda-řetězce analýza   MeSH
• imunoproliferační poruchy imunologie   patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lymfatické uzliny imunologie   patologie   MeSH
• nádory imunologie   patologie   ultrastruktura   MeSH
• paraproteinemie MeSH
• pitva MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• imunoglobulin A MeSH
• imunoglobulin G MeSH
• imunoglobuliny - lambda-řetězce MeSH

We describe the first two ever reported cases of carcinomas arising within ectopic hamartomatous thymoma in 31- and 39-year old men. The carcinomatous change occurred within the adenomatous gland component showing a granular cell quality.

• MeSH
• časové faktory MeSH
• choristom patologie   MeSH
• dospělí MeSH
• hamartom patologie   MeSH
• lidé MeSH
• nádory brzlíku patologie   chirurgie   MeSH
• následné studie MeSH
• thymom patologie   chirurgie   MeSH
• thymus patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Among 36 cases of medullary carcinoma of the thyroid we found two cases of mixed medullary-follicular carcinoma which in addition to the typical morphology contained foci of clear cells with cytological features of papillary carcinoma of the thyroid. The authors compare the two cases with the recently described entity called medullary-papillary carcinoma of thyroid.

• MeSH
• folikulární adenokarcinom klasifikace   patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• medulární karcinom klasifikace   patologie   MeSH
• nádory štítné žlázy klasifikace   patologie   MeSH
• papilární karcinom klasifikace   patologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• srovnávací studie MeSH

A case of dermatofibrosarcoma protuberans in a 39-year old woman excised from the right subclavicular region is described. Beside the typical storiform cellular pattern characteristic of dermatofibrosarcoma protuberans, a considerable part of the tumour displayed a myxoid change. Another part of the tumour exhibited large areas with a fibrosarcoma-like pattern. The transitional areas between these myxoid and fibrosarcoma-like areas resembled a poorly differentiated spindle cell sarcoma. Two years later the tumour recurred. The remarkable feature of the recurrent tumour was the occurrence of multiple giant cells identical to those seen in giant cell fibroblastoma.

• MeSH
• dermatofibrosarkom patologie   chirurgie   MeSH
• dospělí MeSH
• fibrosarkom patologie   chirurgie   MeSH
• lidé MeSH
• lokální recidiva nádoru MeSH
• nádory kůže patologie   chirurgie   MeSH
• následné studie MeSH
• reoperace MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Described in this paper are the ultrastructural features of three cases of palisaded intranodal myofibroblastoma. The tumor cells were identified as myofibroblasts. Abortive vessels formed by the tumor in one case and spindle cell tumorous proliferation outside the tumor capsule and centered on the veins were composed of the same cell types as the cells of the main tumor mass, suggesting that the tumorous myofibroblasts might have originated from the modified smooth muscle cells. The various stages of formation of the intracytoplasmic fuchsinophilic bodies are described in our report.

• MeSH
• elektronová mikroskopie MeSH
• kolagen analýza   ultrastruktura   MeSH
• leiomyom ultrastruktura   MeSH
• lidé MeSH
• lymfatické uzliny ultrastruktura   MeSH
• nádory ze svalové tkáně ultrastruktura   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• kolagen MeSH

A surgically excised lesion from the breast of a 33 year old woman showed apart from cystic disease sclerosing adenosis with distinct myoid differentiation. The myoid bundles were wrapped around original ductules producing a misleading picture which simulated tangentially cut nerves, infiltrated by tumour glands. Immunohistochemically, actin positivity and S-100 protein negativity confirmed the nature of the lesion as sclerosing adenosis.

• MeSH
• buněčná diferenciace MeSH
• diferenciální diagnóza MeSH
• dospělí MeSH
• fibrocystická nemoc prsu patologie   chirurgie   MeSH
• imunohistochemie MeSH
• lidé MeSH
• nádory prsu patologie   MeSH
• prsy inervace   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Five cases of vascular transformation of lymph node sinuses due to venous obstruction are described in this paper. Evidence was found in four cases to actin immunoreactivity, and involvement of myofibroblasts was electronmicroscopically observed in one case. Differential diagnosis of vascular transformation of lymph node sinuses is discussed. The lesion is similar to KAPOSI's sarcoma-like subcutaneous processes and to chemodectoma-like bodies in the lung.

• MeSH
• axila MeSH
• diferenciální diagnóza MeSH
• dospělí MeSH
• elektronová mikroskopie MeSH
• endoplazmatické retikulum ultrastruktura   MeSH
• fibroblasty ultrastruktura   MeSH
• Golgiho aparát ultrastruktura   MeSH
• imunohistochemie MeSH
• Kaposiho sarkom patologie   ultrastruktura   MeSH
• krk MeSH
• lidé středního věku MeSH
• lidé MeSH
• lymfatické nemoci diagnóza   patologie   MeSH
• lymfatické uzliny krevní zásobení   patologie   ultrastruktura   MeSH
• senioři MeSH
• vény patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Reported is a case of an embryonal form of extraskeletal myxoid chondrosarcoma. The tumor cells contained PAS-positive, eccentrically located intracytoplasmatic, hyaline-like globules. These globules seemed to be a hallmark of this tumor, and they reacted strongly with cytokeratin and S-100 protein antibodies. The tumor was negative in reactions with desmin and GFAP antibody.

• MeSH
• chondrosarkom patologie   chirurgie   MeSH
• hyalin cytologie   MeSH
• intermediární filamenta ultrastruktura   MeSH
• kojenec MeSH
• lidé MeSH
• nádorové biomarkery analýza   MeSH
• proteiny intermediálních filament analýza   MeSH
• svaly patologie   MeSH
• Check Tag
• kojenec MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• nádorové biomarkery MeSH
• proteiny intermediálních filament MeSH