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MeSH: dothiepin-farmakologie

9 záznamů v PubMed Filtry

Článek

Disperze QT intervalu. Mýtus nebo diagnostický ukazatel?
[Dispersion of QT intervals--a myth or a diagnostic symptom?]

Casopis lekaru ceskych. 2004 ; 143 (9) : 604-7.

Cas Lek Cesk
ISSN 0008-7335
Zdroj

BACKGROUND: QT interval dispersion (QTd) is conventionally interpreted as a result of repolarization heterogeneity in ventricular myocardium. However, another concept of QTd origin has been discussed recently, suggesting that different projections of the repolarization vector into individual ECG leads could be responsible for the differences in QT interval duration. Moreover, the reproducibility could be influenced by factors both electrocardiographic (T wave amplitude, U wave) and extracardiac (noise, ECG measures). In the presented study we have followed the QTd in two groups of patients with proved changes of an electric heart field. METHODS AND RESULTS: Studied groups: 1. Control group, 2. Healthy pregnant women, 3. Patients treated with dosulepine. QT interval was measured from 80 unipolar chest leads used for body surface potential mapping. The QTd was significantly higher in both experimental groups in comparison with the control group (p < 0.001). Significant correlation was found between the QTd and dosulepine plasma level (p < 0.001). Also amplitude of the T wave loop was in both groups decreased and its width increased (both p < 0.001). CONCLUSIONS: If appropriate procedure of measurement is used, the QTd is significantly increased in many physiological and pathological states. Clinical relevancy of borderline increased values has to be interpreted very carefully.

MeSH
antidepresiva tricyklická farmakologie MeSH
dospělí MeSH
dothiepin farmakologie MeSH
elektrokardiografie * účinky léků MeSH
kardiovaskulární komplikace v těhotenství diagnóza MeSH
lidé MeSH
mapování potenciálů tělesného povrchu MeSH
srdeční arytmie diagnóza MeSH
těhotenství MeSH
Check Tag
dospělí MeSH
lidé MeSH
těhotenství MeSH
ženské pohlaví MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
Názvy látek
antidepresiva tricyklická MeSH
dothiepin MeSH

Článek

Levoprotiline--function regulator of food and satiety centres?

Activitas nervosa superior. 1989 Dec ; 31 (4) : 282-3.

Act Nerv Super (Praha)
ISSN 0001-7604
Zdroj

MeSH
anthraceny terapeutické užití MeSH
antidepresiva terapeutické užití MeSH
bulimia farmakoterapie MeSH
dibenzothiepiny farmakologie MeSH
dospělí MeSH
dothiepin farmakologie MeSH
lidé MeSH
maprotilin analogy a deriváty terapeutické užití MeSH
mentální anorexie farmakoterapie MeSH
mladiství MeSH
Check Tag
dospělí MeSH
lidé MeSH
mladiství MeSH
mužské pohlaví MeSH
Publikační typ
časopisecké články MeSH
Názvy látek
anthraceny MeSH
antidepresiva MeSH
dibenzothiepiny MeSH
dothiepin MeSH
hydroxymaprotilin MeSH Prohlížeč
maprotilin MeSH

Článek

Reduction of vanadate by some psychotropic drugs (chlorpromazine, imipramine and dosulepin) and the effect of bleomycine on Na, K-ATPase

Physiologia Bohemoslovaca. 1985 ; 34 Suppl () : 171-5.

Physiol Bohemoslov
ISSN 0369-9463
Zdroj

The reduction of vanadate (+5V) to vanadyl (+4V) was demonstrated by ESR spectra in the presence of methylene-blue, chlorpromazine, imipramine and dosulepin, but not in the presence of benzodiazepines and Li+. Bleomycine forms an (inactive) complex with +4V which may explain the disinhibition of the brain microsomal Na+-K+ ATPase in the presence of vanadyl. The reduction of +5V to +4V by antidepressants would diminish the binding of +5V to the ATPase and could account for some of the therapeutic action of the drugs in manic-depressive illness.