OBJECTIVE: To determine the preeclampsia-associated features of homeostasis in pregnant woman after ART to clarify the possible mechanisms and factors of preeclampsia. DESIGN: A prospective study. SETTING: Department of Obstetrics, Gynecology and Reproductology, Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine. METHODS: The 150 pregnant woman after ART were examined: 48 with preeclampsia (subgroup 1), 102 preeclampsia-free (subgroup 2). The liver enzymes in blood: alanine aminotransferase (ALT), aspartate aminotransferase (AST); the lipid metabolism indices: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), aterogenity index (AI), triglycerides (TG), 25-hydroxy-vitamin D concentration, cytokines: interleukin-1, -2, -6, -8, -10 (IL-1, IL-2,, IL-6, IL-8, IL-10), tumor necrosis factor (TNF), number of platelets, platelet aggregate function, fibrinogen (F), activated partial thrombin time (aPTT), soluble fibrin monomer complexes (SFMC), D-dimer, von Willebrand factor (VWF) activity were measured. To compare the means Students t-test was used. RESULTS: In women with preeclampsia, the transaminase levels and lipidogram indices (TG, LDL, LDL, AI) are elevated. Blood vitamin D are decreased (25.92±4.76 vs. 38.42±5.12 ng/mL, p.

• Klíčová slova
• Preeclampsia, Vitamin D, assisted reproductive technologies, homeostasis, inflammation, interleukin, liver lipid metabolism, preeclampsia, vitamin,
• MeSH
• homeostáza MeSH
• lidé MeSH
• preeklampsie * MeSH
• prospektivní studie MeSH
• těhotenství MeSH
• těhotné ženy MeSH
• triglyceridy MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• triglyceridy MeSH

OBJECTIVE: The aim of the study was to analyse the results of the implementation of the new health service Registration of a pregnant woman in the maternity hospital (optimally at 36th-37th weeks) provided as part of outpatient/ambulatory health care at Olomouc University Hospital (OUH). MATERIALS AND METHODS: A prospective cohort study. In 2022, a total of 2,271 women gave birth in OUH, and 2,010 of them were Registered in the maternity hospital, defined specific risks were identified and a pregnancy termination strategy was established/determined. RESULTS: The health service was provided to 88.5% of women giving birth (2,010/2,271). The age of the mothers was 15-56 years (mean 31.3 years; median 31 years), their body mass index was 13.4-53.1 kg/m2 (mean 24.6 kg/m2; median 23.2 kg/m2). 43.6% of them (877/2,010) were Low-risk pregnancies and 56.4% (1,133/2,010) were Pregnancies with a defined specific risk. The most frequently identified risks were as follows: RhD negative blood group (18.4%), diabetes mellitus (13.9%), history of caesarean section (12.0%), hypertensive disorders (6.5%), small fetus/fetal growth restriction (6.3%), risk the development of hemolytic disease in the fetus and the newborn (2.5%), multiple pregnancy (1.6%), congenital malformation of the fetus (1.3%) and placentation disorders (0.5%). In 63.4% of them (1,275/2,010), the pregnancy termination strategy was determined by spontaneous vaginal delivery, in 18.0% (361/2,010) by pre-induction of vaginal delivery and in 14.2% (285/2,010) by caesarean section. In 4.4% (89/2,010) the health service was not implemented correctly because no strategy was established. CONCLUSION: The implementation of the new health service will make it possible to replace activity (more frequent antenatal care contacts/visits and routine antenatal cardiotocography) with efficiency (risk identification, determination of the optimal strategy for outpatient/ambulatory antenatal care and timing and mode of delivery) and thereby provide better and safer health care (from a medical, organizational, legislative and economic points of view).

• Klíčová slova
• defined specific risks, final mode of delivery, pregnancy termination strategy, pregnant woman, registration in the maternity hospital,
• MeSH
• císařský řez * MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• novorozenec MeSH
• porodnice MeSH
• prospektivní studie MeSH
• růstová retardace plodu MeSH
• těhotenství MeSH
• těhotné ženy * MeSH
• vedení porodu MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

We present a case of a pregnant woman with systemic lupus erythematosus (SLE) who was diagnosed with asymptomatic complete heart block (CHB) during pregnancy. To evaluate possible risks and benefits of pacemaker (PM) implantation, a multidisciplinary counselling board was held. Its recommendation was to perform PM implantation to prevent intra-uterine growth restriction from insufficient cardiac output using a fluoroscopic protective shield. The procedure was performed without complications and established permanent pacing on onwards ECG examinations. The patient subsequently gave birth to a healthy newborn. After a retrospective clinical case evaluation and review of relevant literature, a presumptive association between CHB and the primary diagnosis was proposed. Above that, pregnant women with SLE who develop hypertension are commonly treated with methyldopa, which may cause conduction abnormalities. Clinical recommendations for young female patients expecting pregnancy are lacking in this area. Careful diagnostic and treatment approaches should be used in the management of possible SLE-related complications in women of child-bearing age, focusing on preventable events.

• Klíčová slova
• complete heart block, lupus erythematosus, methyldopa, pregnancy,
• MeSH
• komplikace těhotenství * terapie   MeSH
• lidé MeSH
• novorozenec MeSH
• retrospektivní studie MeSH
• růstová retardace plodu MeSH
• srdeční blokáda terapie   komplikace   MeSH
• systémový lupus erythematodes * komplikace   MeSH
• těhotenství MeSH
• těhotné ženy MeSH
• Check Tag
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

The cases of antithrombin (AT)-deficient pregnant women with a homozygous HBS II mutation are relatively rare and are accompanied by an increased thrombophilic risk, which is manifested by increased thrombin generation (TG). It is very difficult to ensure their prophylactic treatment during pregnancy. We aimed to determine the utility of the thrombin generation assay (TGA) and anti-factor Xa (anti-FXa) test to monitor the effects of a prophylactic dose of low-molecular-weight heparin (LMWH) in a 28-year-old woman with homozygous AT deficiency caused by mutation c.391C > T#, (p.Leu131Phe†) in the SERPINC1 gene and to compare the findings with those from a group of pregnant and non-pregnant women also treated with LMWH. TG monitoring was chosen due to severe AT deficiency that was manifested by low levels of anti-FXa activity when monitoring the efficacy of LMWH treatment. A significant decrease in TG was detected in all monitored groups (P < .05). There were no thrombotic complications during the whole pregnancy of the woman with AT deficiency. Consistent monitoring of TG with LMWH anticoagulant therapy administration during pregnancy together with AT administration before and after delivery may improve the overall condition of pregnant women and the quality of their care.

• Klíčová slova
• LMWH administration, antithrombin deficiency, homozygous mutation, thrombin generation,
• MeSH
• antikoagulancia terapeutické užití   MeSH
• antithrombin III MeSH
• antitrombiny terapeutické užití   MeSH
• dospělí MeSH
• heparin nízkomolekulární * MeSH
• lidé MeSH
• mutace MeSH
• nedostatek antitrombinu III * farmakoterapie   genetika   MeSH
• těhotenství MeSH
• těhotné ženy MeSH
• trombin terapeutické užití   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• antikoagulancia MeSH
• antithrombin III MeSH
• antitrombiny MeSH
• heparin nízkomolekulární * MeSH
• trombin MeSH

Recurrent pregnancy losses represent sensitive issue not only for the couple, but also for all healthcare professionals involved. In a broader context, they include not only recurrent miscarriages, but also the issue of periviable preterm birth with subsequent neonatal death and unexplained fetal death. This area requires an interdisciplinary approach. The field of reproductive immunology best answers questions related to pregnancy complications. However, there is currently no accurate recommendation as to who should care for such women. In this article I summarize the current state of knowledge about the issue, current experience with care management, including case studies.

• Klíčová slova
• Progesterone, immunoglobulin, immunomodulation, low molecular weight heparin, pregnancy, recurrent pregnancy loss,
• MeSH
• habituální potrat * etiologie   terapie   MeSH
• komplikace těhotenství * diagnóza   terapie   MeSH
• lidé MeSH
• novorozenec MeSH
• předčasný porod * MeSH
• těhotenství MeSH
• těhotné ženy MeSH
• Check Tag
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Rectal squamous cell carcinoma (RSCC) belongs to rare gastrointestinal malignancies. There are no consensus recommendations for the treatment of non-metastatic RSCC, which can cause problems when considering optimal therapy. PURPOSE: The objective of this report is to point out that RSCC is a rare disease which needs to be distinguished from anal squamous cell cancer (ASCC) and the treatment of which differs from that of rectal adenocarcinoma. CASE REPORT: We discuss the dia-gnosis and therapy of a patient with non-metastatic RSCC. A forty-two-year-old woman with a history of diarrhea and rectal bleeding was dia-gnosed for RSCC with locoregional lymphadenopathy, stage T3N1MO. Protective sigmostomy was performed for stenotizing tumor; then the patient underwent chemoradiotherapy with the effect of complete response in MR scans. Subsequently, the patient underwent rectal resection according to Dixon with histological confirmation of complete tumor regression and without detection of residual tumor in the rectum. CONCLUSION: It can be sometimes difficult to distinguish primary RSCC from ASCC. Nowadays, there is no standardized staging system for RSCC, and it causes problems in comparative studies as well as in the determination of treatment protocols. The backbone of RSCC treatment is chemoradiotherapy.

• Klíčová slova
• chemotherapy, radiotherapy, rectal cancer, squamous cell, tumor staging,
• MeSH
• chemoradioterapie * MeSH
• dospělí MeSH
• lidé MeSH
• nádory rekta * diagnóza   patologie   terapie   MeSH
• spinocelulární karcinom * diagnóza   patologie   terapie   MeSH
• staging nádorů MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

The first successful operation of endomyocardial fibrosis in a young woman in Hungary is reported. Left ventricular endocardial thickening had been diagnosed preoperatively using two-dimensional echocardiography.

• MeSH
• dospělí MeSH
• echokardiografie MeSH
• endokard chirurgie   MeSH
• endomyokardiální fibróza diagnóza   chirurgie   MeSH
• lidé MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

• Klíčová slova
• LISTERIA INFECTIONS/case reports *, MENINGOENCEPHALITIS/etiology *,
• MeSH
• chorobopisy * MeSH
• dospělí MeSH
• lidé MeSH
• listeriová meningitida * MeSH
• listeriové infekce * MeSH
• meningoencefalitida etiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Primary primitive neuroectodermal tumors (PNETs) are extremely rare in the lung and especially in adult women. We describe a case of PNET of the lung with aggressive behavior in 31-year-old woman. Diagnosis was based on histopathological and immunohistochemical studies, and confirmed by molecular genetic analysis of chromosome rearrangements in the EWSR1 gene region. Clinical follow-up, post-mortem findings, and differential diagnosis are also discussed.

• MeSH
• anemie chemicky indukované   patologie   MeSH
• diferenciální diagnóza MeSH
• dospělí MeSH
• fatální výsledek MeSH
• lidé MeSH
• nádory plic farmakoterapie   patologie   MeSH
• primitivní neuroektodermové nádory farmakoterapie   patologie   MeSH
• protinádorové látky škodlivé účinky   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• protinádorové látky MeSH

• Klíčová slova
• LAUNDRIES *,
• MeSH
• elektřina * MeSH
• nemocniční prádelny * MeSH
• potřeby pro domácnost * MeSH
• pracující ženy * MeSH
• praní * MeSH
• Publikační typ
• časopisecké články MeSH