Sepsis is considered to be the major cause of morbidity and mortality of patients hospitalised in intensive care. It's defined as a systemic inflammatory response of organism to infection. Incidence of myocardial dysfunction in studies with severe sepsis patients is up to two thirds of patients. Cardiac dysfunction shows a continuum from isolated and mild diastolic dysfunction to combined severe diastolic and systolic failure of both ventricles mimicking even cardiogenic shock in some patients. Typical features of septic myocardial dysfunction (SMD) are decrease in ejection fraction (EF) with dilatation ofventricles, e.g. increase in end-diastolic volume (EDV). Reversibility of myocardial dysfunction during a period from 7 to 10 days in survivors is other typical manifestation of SMD. Hence, one can speculate that development of such a type ofSMD as a temporary protective compensatory mechanism could be advantageous for of an individual patient. A large body ofevidence about mechanisms ofSMD was described; endothelial dysfunction with consequent microcirculatory and mitochondrial dysfunction and role of circulating factors are considered to be the most important.

• MeSH
• autonomní nervový systém patofyziologie   MeSH
• cytokiny fyziologie   MeSH
• endotoxiny fyziologie   MeSH
• kardiomyopatie etiologie   patofyziologie   MeSH
• koronární cirkulace MeSH
• lidé MeSH
• myofibrily fyziologie   MeSH
• myokard metabolismus   MeSH
• oxid dusnatý fyziologie   MeSH
• sepse komplikace   MeSH
• srdeční mitochondrie fyziologie   MeSH
• TNF-alfa fyziologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• cytokiny MeSH
• endotoxiny MeSH
• oxid dusnatý MeSH
• TNF-alfa MeSH

Using suitable immunomodulators (Corynebacterium parvum vaccine, Zymosan or muramyl dipeptide), lipopolysaccharides (LPS) from various members of the family Enterobacteriaceae (Escherichia, Salmonella, Serratia, Shigella) were tested on rabbits in relation to the production of tumor necrosis factor (TNF). TNF was determined by means of the serum titration of L-929 cell cultures in the presence of Actinomycin D, this with resulting titres of 3.2 x 10(3) to 5.1 x 10(4) IU TNF/ml. Analogous titres were noted after the action of denatured LPS (ie LPS subjected to alkaline hydrolysis or H2O2).

• MeSH
• adjuvancia imunologická fyziologie   MeSH
• endotoxiny fyziologie   MeSH
• Enterobacteriaceae fyziologie   MeSH
• králíci MeSH
• lipopolysacharidy fyziologie   MeSH
• myši MeSH
• TNF-alfa biosyntéza   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• adjuvancia imunologická MeSH
• endotoxiny MeSH
• lipopolysacharidy MeSH
• TNF-alfa MeSH

• MeSH
• chemotaxe * MeSH
• endotoxiny fyziologie   MeSH
• fagocytóza MeSH
• imunokomplex MeSH
• infekce imunologie   MeSH
• komplement fyziologie   MeSH
• leukocyty imunologie   MeSH
• lidé MeSH
• pohyb buněk MeSH
• tvorba protilátek MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• endotoxiny MeSH
• imunokomplex MeSH
• komplement MeSH