• MeSH
• časové faktory MeSH
• fertilizace MeSH
• prostaglandiny F syntetické aplikace a dávkování   MeSH
• skot MeSH
• synchronizace říje účinky léků   MeSH
• těhotenství MeSH
• zvířata MeSH
• Check Tag
• skot MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• prostaglandiny F syntetické MeSH

Photometric observations of the near-Earth asteroid (31345) 1998 PG by Pravec et al. (2000) found a rotation period of 2.51620 h. Also found was a secondary period of 7.0035 h, or the double-period of 14.007 h, possibly indicating an additional body in the system. An extended campaign by the authors in 2018 lead to a similar primary period of 2.5168 h. However, instead of a 7-hour secondary period, one of about 16 hours was found with the lightcurve showing apparent mutual events (occultations and/or eclipses). The data sets from 1998 and 2018 could not be fit to a secondary period near the one found at the opposing apparition. The conclusion is that the asteroid is very likely binary, but - other than the primary rotation period - the system's parameters are ill-defined and only future observations will sufficiently refine them.

• Publikační typ
• časopisecké články MeSH

• Publikační typ
• časopisecké články MeSH
• tisková chyba MeSH

Renal cell carcinomas with t(6;11) chromosome translocation involving the TFEB gene are indolent neoplasms which often occur in young patients. In this study, we report seven cases of renal cell carcinoma with TFEB rearrangement, two of whom had histologically proven metastasis. Patients (4F, 3M) ranged in age from 19 to 55 years (mean 37). One patient developed paratracheal and pleural metastases 24 months after surgery and died of disease after 46 months; another one recurred with neoplastic nodules in the perinephric fat and pelvic soft tissue. Histologically, either cytological or architectural appearance was peculiar in each case whereas one tumor displayed the typical biphasic morphology. By immunohistochemistry, all tumors labelled for cathepsin K, Melan-A and CD68 (KP1 clone). HMB45 and PAX8 staining were detected in six of seven tumors. All tumors were negative for CD68 (PG-M1 clone), CKAE1-AE3, CK7, CAIX, and AMACR. Seven pure epithelioid PEComa/epithelioid angiomyolipomas, used as control, were positive for cathepsin K, melanocytic markers, and CD68 (PG-M1 and KP1) and negative for PAX8. Fluorescence in situ hybridization results showed the presence of TFEB gene translocation in all t(6;11) renal cell carcinomas with a high frequency of split TFEB fluorescent signals (mean 74%). In the primary and metastatic samples of the two aggressive tumors, increased gene copy number was observed (3-5 fluorescent signals per neoplastic nuclei) with a concomitant increased number of CEP6. Review of the literature revealed older age and larger tumor size as correlating with aggressive behavior in these neoplasms. In conclusion, we present the clinical, morphological and molecular features of seven t(6;11) renal cell carcinomas, two with histologically demonstrated metastasis. We report the high frequency of split signals by FISH in tumors with t(6;11) chromosomal rearrangement and the occurrence of TFEB gene copy number gains in the aggressive cases, analyzing either the primary or metastatic tumor. Finally, we demonstrate the usefulness of CD68 (PG-M1) immunohistochemical staining in distinguishing t(6;11) renal cell carcinoma from pure epithelioid PEComa/epithelioid angiomyolipoma.

• MeSH
• angiomyolipom chemie   patologie   MeSH
• antigeny diferenciační myelomonocytární analýza   MeSH
• CD antigeny analýza   MeSH
• diferenciální diagnóza MeSH
• dospělí MeSH
• hybridizace in situ fluorescenční MeSH
• imunohistochemie MeSH
• karcinom z renálních buněk chemie   genetika   sekundární   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lidské chromozomy, pár 11 genetika   MeSH
• lidské chromozomy, pár 6 genetika   MeSH
• nádorové biomarkery analýza   MeSH
• nádory ledvin chemie   genetika   patologie   MeSH
• nádory z perivaskulárních epiteloidních buněk chemie   patologie   MeSH
• transkripční faktory BHLH-Zip genetika   MeSH
• translokace genetická MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antigeny diferenciační myelomonocytární MeSH
• CD antigeny MeSH
• CD68 antigen, human MeSH Prohlížeč
• nádorové biomarkery MeSH
• TFEB protein, human MeSH Prohlížeč
• transkripční faktory BHLH-Zip MeSH

The evolutionary success of beetles and numerous other terrestrial insects is generally attributed to co-radiation with flowering plants but most studies have focused on herbivorous or pollinating insects. Non-herbivores represent a significant proportion of beetle diversity yet potential factors that influence their diversification have been largely unexamined. In the present study, we examine the factors driving diversification within the Scarabaeidae, a speciose beetle family with a range of both herbivorous and non-herbivorous ecologies. In particular, it has been long debated whether the key event in the evolution of dung beetles (Scarabaeidae: Scarabaeinae) was an adaptation to feeding on dinosaur or mammalian dung. Here we present molecular evidence to show that the origin of dung beetles occurred in the middle of the Cretaceous, likely in association with dinosaur dung, but more surprisingly the timing is consistent with the rise of the angiosperms. We hypothesize that the switch in dinosaur diet to incorporate more nutritious and less fibrous angiosperm foliage provided a palatable dung source that ultimately created a new niche for diversification. Given the well-accepted mass extinction of non-avian dinosaurs at the Cretaceous-Paleogene boundary, we examine a potential co-extinction of dung beetles due to the loss of an important evolutionary resource, i.e., dinosaur dung. The biogeography of dung beetles is also examined to explore the previously proposed "out of Africa" hypothesis. Given the inferred age of Scarabaeinae as originating in the Lower Cretaceous, the major radiation of dung feeders prior to the Cenomanian, and the early divergence of both African and Gondwanan lineages, we hypothesise that that faunal exchange between Africa and Gondwanaland occurred during the earliest evolution of the Scarabaeinae. Therefore we propose that both Gondwanan vicariance and dispersal of African lineages is responsible for present day distribution of scarabaeine dung beetles and provide examples.

• MeSH
• biodiverzita MeSH
• biologická evoluce * MeSH
• brouci * MeSH
• dinosauři * MeSH
• ekologie MeSH
• extinkce biologická * MeSH
• feces MeSH
• fylogeneze MeSH
• Magnoliopsida MeSH
• sekvenční analýza DNA MeSH
• zkameněliny MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

UNLABELLED: The objective of the study was to determine whether there exists a difference in the central cornea thickness (CCT) in patients with hypertensive (HTG) and normotensive glaucoma (NTG), and subsequently, to compare the application of prostaglandins by corrected CCT (CCT correction) for both types of glaucoma. MATERIAL AND METHODS: 100 eyes of 50 patients (the average age of 67) with HTG and 100 eyes of 50 patients (the average age of 62.6) with NTG were examined. Antiglaucomatics, if indicated, were taken by the patients for at least the preceding five years. The excluding criteria in the study were: cornea diseases, post-laser procedure conditions and high ametropia. CCT was measured by means of Tomey Handy Pachymeter SP100 by the same physician. RESULTS: A two-sample t-test was applied in order to compare the measurement values of CCT and the subsequent correction of these values (CCT correction) in patients with HTG and NTG. The statistical evaluation showed that in case of both CCT and CCT correction, the values were lower in the group of NTG patients in comparison with HTG patients. With respect to CCT, the difference was statistically insignificant (NTG 554.9±35.7 vs. HTG 561.4 ± 32.7, p = 0.181). In case of CCT correction, the difference was more considerable, but still statistically insignificant (NTG 550.8 ± 35 vs. HTG 559.6 ± 33.1, p = 0.06). CONCLUSION: CCT was higher in NTG than in HTG; however, these values were statistically insignificant. A comparison of the application of prostaglandins of corrected CCT (CCT correction) for both types of glaucoma increased the difference, but this difference was still statistically insignificant. This difference was caused by an uneven representation of patients treated with prostaglandins in both groups. Key words: hypertensive glaucoma, normotensive glaucoma, central cornea thickness, prostaglandins.

• Klíčová slova
• central cornea thickness, hypertensive glaucoma, normotensive glaucoma, prostaglandins,
• MeSH
• glaukom * komplikace   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nitrooční tlak * MeSH
• prostaglandiny syntetické MeSH
• rohovka * patologie   MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• prostaglandiny syntetické MeSH

Purpose: To evaluate the utility of preoperative diagnostic models for ovarian cancer based on ultrasound and/or biomarkers for referring patients to specialized oncology care. The investigated models were RMI, ROMA, and 3 models from the International Ovarian Tumor Analysis (IOTA) group [LR2, ADNEX, and the Simple Rules risk score (SRRisk)].Experimental Design: A secondary analysis of prospectively collected data from 2 cross-sectional cohort studies was performed to externally validate diagnostic models. A total of 2,763 patients (2,403 in dataset 1 and 360 in dataset 2) from 18 centers (11 oncology centers and 7 nononcology hospitals) in 6 countries participated. Excised tissue was histologically classified as benign or malignant. The clinical utility of the preoperative diagnostic models was assessed with net benefit (NB) at a range of risk thresholds (5%-50% risk of malignancy) to refer patients to specialized oncology care. We visualized results with decision curves and generated bootstrap confidence intervals.Results: The prevalence of malignancy was 41% in dataset 1 and 40% in dataset 2. For thresholds up to 10% to 15%, RMI and ROMA had a lower NB than referring all patients. SRRisks and ADNEX demonstrated the highest NB. At a threshold of 20%, the NBs of ADNEX, SRrisks, and RMI were 0.348, 0.350, and 0.270, respectively. Results by menopausal status and type of center (oncology vs. nononcology) were similar.Conclusions: All tested IOTA methods, especially ADNEX and SRRisks, are clinically more useful than RMI and ROMA to select patients with adnexal masses for specialized oncology care. Clin Cancer Res; 23(17); 5082-90. ©2017 AACR.

• MeSH
• diferenciální diagnóza * MeSH
• hodnocení rizik MeSH
• lékařská onkologie trendy   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádorové biomarkery krev   MeSH
• nádory vaječníků diagnóza   diagnostické zobrazování   epidemiologie   patologie   MeSH
• nemoci děložních adnex diagnóza   epidemiologie   patologie   MeSH
• senioři MeSH
• ultrasonografie MeSH
• výběr pacientů MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• nádorové biomarkery MeSH

AIM: The aim of the study was to evaluate the efficacy, safety and local tolerability of preservative-free tafluprost 0.0015% (Taflotan®) in patients with glaucoma and ocular hypertension. MATERIALS AND METHODS: Multicentric, prospective observation study was performed in the Czech Republic from October 2010 to April 2011. A total of 78 centers participated and 754 patients were included. After the doctors decision to start the treatment with Taflotan®, the patients demographic data, previous treatment, intraocular pressure and the reason for switching the medication were recorded. At the follow-up visit after 6-12 weeks, the intraocular pressure, local tolerability (a 5-level scale), the patients and doctors satisfaction (a 4-level scale), and the patients preference were recorded. RESULTS: Altogether, data of 496 patients were evaluated. The majority of them were women (64.9 %). The patients mean age was 58.5 years. The most common diagnosis was primary open angle glaucoma (79.2 %), followed by ocular hypertension (7.3 %), normal tension glaucoma (4.2 %), and pseudoexfoliation glaucoma (3.6 %). In 140 patients, tafluprost 0.0015% was the first antiglaucomatous medication started, 261 patients switched from another monotherapy, and 95 patients were treated with fixed- or nonfixed combinations before starting tafluprost 0.0015%. The most common reason for switching to Taflotan® was local intolerability to the current antiglaucomatous therapy (most often irritation of the eye and hyperemia). The intraocular pressure decreased significantly from 19.9 ± 4.5 mm Hg to 16.3 ± 3.0 mm Hg (p < 0.001). The subjective tolerability of the antiglaucomatous therapy improved rapidly, with 57.4 % of patients rating the tolerability of Taflotan® as "very good" and 34.5 % as "good". In addition, 94.4 % of patients and 96.0 % of ophthalmologists were "very satisfied" or "satisfied" with the treatment. At the final visit, 79.8 % of patients preferred Taflotan® to the previous treatment. CONCLUSION: Taflotan® significantly decreased the intraocular pressure. It was well tolerated even in patients with previous intolerability to another antiglaucomatous therapy, including prostaglandins. The patients and ophthalmologists satisfaction with Taflotan® was high.

• MeSH
• dítě MeSH
• dospělí MeSH
• glaukom farmakoterapie   patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• nitrooční tlak účinky léků   MeSH
• oční hypertenze farmakoterapie   patofyziologie   MeSH
• prostaglandiny F škodlivé účinky   terapeutické užití   MeSH
• prostaglandiny syntetické škodlivé účinky   terapeutické užití   MeSH
• senioři MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• multicentrická studie MeSH
• Názvy látek
• prostaglandiny F MeSH
• prostaglandiny syntetické MeSH
• tafluprost MeSH Prohlížeč

• MeSH
• dysplazie děložního hrdla diagnóza   virologie   MeSH
• infekce papilomavirem komplikace   diagnóza   MeSH
• lidé MeSH
• nádory děložního čípku diagnóza   virologie   MeSH
• Papillomaviridae * MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• dopisy MeSH
• komentáře MeSH

• MeSH
• cyproteron farmakologie   MeSH
• estrus účinky léků   MeSH
• luteinizační hormon krev   MeSH
• ovce krev   fyziologie   MeSH
• progesteron krev   MeSH
• prolaktin krev   MeSH
• prostaglandiny syntetické farmakologie   MeSH
• roční období * MeSH
• těhotenství MeSH
• zvířata MeSH
• Check Tag
• těhotenství MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• cyproteron MeSH
• luteinizační hormon MeSH
• progesteron MeSH
• prolaktin MeSH
• prostaglandiny syntetické MeSH