Two studies designed to investigate the effect of recombinant human erythropoietin (rHuEPO) treatment of anemia in chronic dialysis patients on hemocompatibility were conducted. Study 1, whose main aim was to establish whether treatment with rHuEPO enhances coagulation activation during dialysis, included 15 patients before rHuEPO therapy at a mean hematocrit (HCT) of 22.3% and then during therapy at a HCT of 29.3%. The plasma concentrations of the thrombin-antithrombin III complex were not higher during rHuEPO therapy than before it when performing hemodialysis with a Cuprophan membrane. No significant difference was demonstrated either in the values of activated clotting times (Hemochron), thrombocyte or white blood cell counts (Coulter S+II), or in plasma C5a concentrations (ELISA) established during dialysis sessions before and during rHuEPO therapy. In Study 2, which focused primarily on the question of whether or not rHuEPO therapy increases thrombocyte activation during hemodialysis, 8 patients on chronic dialysis were examined both before therapy at a mean HCT value of 22.1% and during rHuEPO therapy at a HCT of 31.5%, invariably during dialysis with either a Cuprophan or polyacrylonitrile (AN69HF) membrane. The plasma concentrations of beta-thromboglobulin (ELISA) did not differ between the examinations made during rHuEPO and before rHuEPO therapy; however, statistically significant differences were found between dialysis sessions involving Cuprophan and AN69HF membranes. No significant difference between examination before and during rHuEPO was demonstrated in activated clotting time nor thrombocyte and white blood cell counts in this study either. The authors conclude that rHuEPO therapy does not enhance coagulation activation during hemodialysis, does not have an effect on thrombocyte activation, and does not influence complement activation and changes in white blood cell counts.

• MeSH
• akrylové pryskyřice metabolismus   MeSH
• beta-thromboglobulin metabolismus   MeSH
• celulosa analogy a deriváty   metabolismus   MeSH
• dialýza ledvin * MeSH
• dospělí MeSH
• ELISA MeSH
• erythropoetin aplikace a dávkování   terapeutické užití   MeSH
• histokompatibilita MeSH
• komplement C5a metabolismus   MeSH
• krevní proteiny metabolismus   MeSH
• lidé středního věku MeSH
• lidé MeSH
• membrány umělé MeSH
• rekombinantní proteiny aplikace a dávkování   terapeutické užití   MeSH
• trombocyty cytologie   účinky léků   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• akrylové pryskyřice MeSH
• beta-thromboglobulin MeSH
• celulosa MeSH
• cuprammonium cellulose MeSH Prohlížeč
• erythropoetin MeSH
• komplement C5a MeSH
• krevní proteiny MeSH
• membrány umělé MeSH
• polyacrylonitrile MeSH Prohlížeč
• rekombinantní proteiny MeSH

Permeation of inorganic salts in water-swollen silicone rubber-hydrogel composites consisting of a silicone rubber matrix and lightly cross-linked particles of poly(2-hydroxyethyl methacrylate), poly(2-hydroxyethyl methacrylate-co-methacrylic acid), poly(methacrylic acid), polyacrylamide or poly(acrylamide-co-methacrylic acid) hydrogels was investigated. The results, together with earlier data on permeation of non-ionic low-molecular-weight substances through the composite materials, were evaluated in terms of the free-volume diffusion theory. It was found that the materials with water content exceeding a certain limit are highly permeable to the salts, and that, as regards permeation properties, they behave as homogeneous water-swollen hydrogels. The dependence of electrical conductivity of the water-swollen composites on the hydrogel phase content was measured, and the results are discussed in relation to other transport properties and to the structure of the materials.

• MeSH
• akrylové pryskyřice chemie   metabolismus   MeSH
• biokompatibilní materiály normy   MeSH
• difuze MeSH
• elektrická vodivost MeSH
• gely MeSH
• kyseliny polymethakrylové chemie   metabolismus   MeSH
• matematika MeSH
• methylmetakryláty chemie   metabolismus   MeSH
• molekulová hmotnost MeSH
• polyhydroxyethylmethakrylát chemie   metabolismus   MeSH
• polymery MeSH
• protézy a implantáty MeSH
• reagencia zkříženě vázaná MeSH
• silikonové elastomery chemie   metabolismus   MeSH
• složené pryskyřice chemie   metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• akrylové pryskyřice MeSH
• biokompatibilní materiály MeSH
• gely MeSH
• HTR composite MeSH Prohlížeč
• kyseliny polymethakrylové MeSH
• methylmetakryláty MeSH
• polyacrylamide gels MeSH Prohlížeč
• polyhydroxyethylmethakrylát MeSH
• polymery MeSH
• polymethacrylic acid MeSH Prohlížeč
• reagencia zkříženě vázaná MeSH
• silikonové elastomery MeSH
• složené pryskyřice MeSH

• MeSH
• akrylové pryskyřice chemická syntéza   chemie   metabolismus   MeSH
• fluorescein MeSH
• fluoresceiny MeSH
• lektiny metabolismus   MeSH
• metabolismus sacharidů MeSH
• molekulární sekvence - údaje MeSH
• molekulární struktura MeSH
• sacharidové sekvence MeSH
• vazebná místa MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• akrylové pryskyřice MeSH
• fluorescein MeSH
• fluoresceiny MeSH
• lektiny MeSH
• polyacrylamide MeSH Prohlížeč

• MeSH
• akrylamidy metabolismus   MeSH
• akrylové pryskyřice metabolismus   MeSH
• játra metabolismus   MeSH
• králíci MeSH
• krysa rodu Rattus MeSH
• kyseliny polymethakrylové metabolismus   MeSH
• ledviny metabolismus   MeSH
• náhražky plazmy metabolismus   MeSH
• slezina metabolismus   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• akrylamidy MeSH
• akrylové pryskyřice MeSH
• kyseliny polymethakrylové MeSH
• náhražky plazmy MeSH