- MeSH
- chronické selhání ledvin krev MeSH
- dialýza ledvin MeSH
- dospělí MeSH
- dusík močoviny v krvi * MeSH
- homologní transplantace MeSH
- lidé středního věku MeSH
- lidé MeSH
- tělesná námaha * MeSH
- transplantace ledvin MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
Colored-grain wheat genotypes were used in the preparation of flour, dough, buns, and buns stored for a short period of time. The main carotenoid in all genotypes was lutein, followed by its esters, zeaxanthin, and β-carotene, while antheraxanthin and α-carotene occurred only at negligible levels. The highest carotenoid contents were observed in yellow- and purple-grained genotypes. After the preparation of dough, total carotenoid content (TCC) decreased significantly by an average of 61.5%. Zeaxanthin was shown to be stable, whereas α-carotene was destroyed. In baked buns, the average decrease of TCC and all-E-lutein was lower than in unbaked dough. Greater decreases were recorded for esters, antheraxanthin, and β-carotene. After storing buns for 24 h at room temperature, approximately one-quarter of TCC observed in the original flour was preserved. Z-Isomers of lutein occurred in minor concentrations, but the degradation of this component, and that of zeaxanthin, was low, suggesting E- to Z-isomerization.
- Klíčová slova
- Antheraxanthin (PubChem CID: 5281223), Baked buns, Colored-grain wheat genotypes, Dough, Esterified carotenoids, Flour, Lutein (PubChem CID: 5281243), Non-esterified carotenoids, Short-term stored buns, Zeaxanthin (PubChem CID: 5280899), α-Carotene (PubChem CID: 4369188), β-Carotene (PubChem CID: 5280489),
- MeSH
- barva MeSH
- genotyp MeSH
- karotenoidy chemie MeSH
- lutein analýza MeSH
- mouka analýza MeSH
- pšenice chemie genetika metabolismus MeSH
- spektrofotometrie ultrafialová MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- zeaxanthiny analýza MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- karotenoidy MeSH
- lutein MeSH
- zeaxanthiny MeSH
BACKGROUND: This retrospective study examines the relationship between admission Blood Urea Nitrogen (BUN) levels and clinical outcomes in patients with sepsis from two separate cohorts in the Czech Republic and the United States. METHODS: The study included 9126 patients with sepsis between January 2014 and December 2018. Kaplan-Meier survival curves and Cox regression were used to analyse the data. An optimal cut-off was calculated by means of the Youden-Index. RESULTS: BUN at ICU admission was categorized as 10-20, 20-40 and >40 mg/dL. Comparing the group with the highest BUN levels to the one with lowest levels, we found HR for 28 days mortality 2.764 (CI 95% 2.37-3.20; P<0.001). We derived an optimal cut-off for prediction of 28 days mortality of 23 mg/dL. The association between BUN and 28 days mortality remained significant after adjusting for potential confounders - for APACHE IV (HR 1.374; 95%CI 1.20-1.58; P<0.001), SAPS2 (HR 1.545; 95%CI 1.35-1.77; P<0.001), eGFR (HR 1.851; 95%CI 1.59-2.16; P<0.001) and several other variables in an integrative model. CONCLUSIONS: Our findings support the BUN level as an independent and easily available predictor of 28 days mortality in septic critically ill patients admitted to an ICU.
- Klíčová slova
- AMPHIBIA *, BIRDS *, CRUSTACEA *, ELECTROPHYSIOLOGY *, EXPERIMENTAL LAB STUDY *, FISHES *, GUINEA PIGS *, MYOCARDIUM *, RABBITS *, RATS *, REPTILES *, REVIEW *, RODENTS *, SPECIES SPECIFICITY *,
- MeSH
- druhová specificita * MeSH
- elektrofyziologie * MeSH
- hlodavci * MeSH
- korýši * MeSH
- králíci MeSH
- krysa rodu Rattus MeSH
- morčata MeSH
- myokard * MeSH
- obojživelníci * MeSH
- plazi * MeSH
- ptáci * MeSH
- ryby * MeSH
- výzkum * MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- krysa rodu Rattus MeSH
- morčata MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Klíčová slova
- CELL DIVISION *, CHROMOSOMES *, CULTURE MEDIA *, EMBRYO *, INFANT, NEWBORN *, TISSUE CULTURE *,
- MeSH
- buněčné dělení * MeSH
- chromozomy * MeSH
- diploidie * MeSH
- embryo nesavčí * MeSH
- embryo savčí * MeSH
- kojenec MeSH
- kultivační média * MeSH
- lidé MeSH
- novorozenec MeSH
- techniky tkáňových kultur * MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kultivační média * MeSH
- Klíčová slova
- ADENOCARCINOMA *, CELL DIVISION *, CELL NUCLEUS *, EXPERIMENTAL LAB STUDY *, TISSUE CULTURE *, UTERINE NEOPLASMS *,
- MeSH
- adenokarcinom * MeSH
- buněčné dělení * MeSH
- buněčné jádro * MeSH
- lidé MeSH
- nádory dělohy * MeSH
- techniky tkáňových kultur * MeSH
- výzkum * MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Novel nickel(ii) complexes bearing ( t butyl)bis(diphenylphosphanyl)amine and different halogenido ligands, [Ni(P,P)X2] = [Ni{ t BuN(PPh2)2-κ2P}X2], (X = Cl, Br, I) are prepared, characterized by IR and NMR spectroscopy, mass spectrometry and X-ray crystallography, and tested as catalysts in the Kumada cross-coupling reaction of model substituted iodobenzenes and p-tolylmagnesium bromide. The data obtained together with DFT calculations indicate that these new catalysts operate in the Ni(i)-Ni(iii) mode. The highest catalytic activity and selectivity are exhibited by [Ni(P,P)Cl2], which is most easily reduced by the used Grignard reagent to the Ni(i) state. This process is much more energy demanding in the case of the bromido and iodido complexes, causing the appearance of the induction period. [Ni(P,P)Cl2] is also very active in the cross-couplings of substrates with iodine atoms sterically shielded by ortho substituents. The data obtained are in good accordance with the described positive effect of the increased electron-releasing power of N-substituents R' on the overall catalytic performance of [Ni{R'N(PPh2)2-κ2P}X2] complexes.
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- CARCINOMA 256, WALKER *, DNA, NEOPLASM *, EXPERIMENTAL LAB STUDY *, LIVER *, LUNG *, PHOSPHORUS ISOTOPES *, RADIOAUTOGRAPHY *, RATS *, SPLEEN *, THYMIDINE *, TRITIUM *,
- MeSH
- autoradiografie * MeSH
- DNA nádorová * MeSH
- DNA * MeSH
- izotopy fosforu * MeSH
- játra * MeSH
- karcinom Walkerův 256 * MeSH
- krysa rodu Rattus MeSH
- nádory * MeSH
- plíce * MeSH
- slezina * MeSH
- thymidin * MeSH
- tritium * MeSH
- výzkum * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- DNA nádorová * MeSH
- DNA * MeSH
- izotopy fosforu * MeSH
- thymidin * MeSH
- tritium * MeSH
- Klíčová slova
- CELL DIVISION *, CONNECTIVE TISSUE *, CULTURE MEDIA *, EXPERIMENTAL LAB STUDY *, FIBROBLASTS *, L CELLS *, MICE *, RADIATION EFFECTS *, TISSUE CULTURE *,
- MeSH
- buněčné dělení * MeSH
- fibroblasty * MeSH
- kultivační média * MeSH
- L buňky (buněčná linie) * MeSH
- myši MeSH
- pojivová tkáň * MeSH
- radiační účinky * MeSH
- techniky tkáňových kultur * MeSH
- výzkum * MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kultivační média * MeSH
- Klíčová slova
- CULTURE MEDIA *, EXPERIMENTAL LAB STUDY *, KIDNEY *, MONKEYS *, TISSUE CULTURE *,
- MeSH
- Haplorrhini * MeSH
- kultivační média * MeSH
- ledviny * MeSH
- Macaca mulatta * MeSH
- techniky tkáňových kultur * MeSH
- výzkum * MeSH
- výzkumný projekt * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kultivační média * MeSH
