Klinické studie Dotaz Zobrazit nápovědu

Reset

4 363 záznamů v PubMed

Článek

Rozhodovací síla klinické studie
[The decision-making value of clinical studies]

Casopis lekaru ceskych. 1983 Mar 25 ; 122 (12) : 374-7.

Cas Lek Cesk
ISSN 0008-7335
Zdroj

Článek

Randomizované klinické studie v ortopedické chirurgii
[Randomized clinical studies in orthopedic surgery]

Surin, V V
Autor Surin, V V

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca. 1989 Jun ; 56 (3) : 245-52.

Acta Chir Orthop Traumatol Cech
ISSN 0001-5415
Zdroj

The author describes the conditions and advantages of a prospective clinical investigation. He analyzes also the reasons why this type of investigation of the effectiveness of new surgical methods is used so little in orthopaedic surgery.

Článek

Randomizované klinické glaukomové studie--výsledky a úvahy
[Randomized clinical glaucoma trials--results and considerations]

Kraus, H
Autor Kraus, H Ocní klinika 1, lékarské fakulty UK a VFN, Praha. h.kraus@quick.cz

Ceska a slovenska oftalmologie. 2005 Jul ; 61 (4) : 231-4.

Cesk Slov Oftalmol
ISSN 1211-9059
Zdroj

MeSH
glaukom terapie MeSH
lidé MeSH
randomizované kontrolované studie jako téma MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
přehledy MeSH

Článek

Pediatric trauma score v klinické praxi: retrospektivní studie
[Pediatric trauma score in clinical practice: retrospective study]

The authors evaluated in a retrospective study a group of 257 children associated injuries. ...

Rozhledy v chirurgii. 1991 Sep ; 70 (8-9) : 430-5.

Rozhl Chir
ISSN 0035-9351
Zdroj

In traumatological practice there is so far no uniform view as regards the classification of injuries. The authors recommend to do away with the vague traumatological terminology and replace in by a similar classification: to use the term "monotrauma" when one bodily system is affected and the term "associated injury" when two or more systems are effected; to use for more accurate definition of the severity of injury a scoring system. For paediatric traumatological practice the Pediatric Trauma Score P.T.S./is simple and suited best. The authors evaluated in a retrospective study a group of 257 children associated injuries. Based on the results of this investigation the authors consider P.T.S. a suitable scoring system for the objective evaluation of the general condition of the injured child and recommend its introduction into practice.

Článek

Predikce predcasného porodu--multifaktoriální analýza prospektivní klinické studie
[Prediction of premature labor--multifactorial analysis of a prospective clinical study]

DESIGN: Prospective, observational, clinical study. ...

Ceska gynekologie. 2002 Mar ; 67 (2) : 58-65.

Ceska Gynekol
ISSN 1210-7832
Zdroj

OBJECTIVE: To evaluate, which of selected anamnestic, laboratory and ultrasonographic (USG) parameters could contribute to the prediction of prematurity. DESIGN: Prospective, observational, clinical study. SETTING: Department of Obstetrics and Gynecology, 1st Faculty of Medicine and the General Faculty Hospital, Charles University, Prague. METHODS: 349 women with the singleton pregnancy were followed from the half of the 2nd trimester until the end of gestation. At each woman the anamnestic (age, parity, pregravid BMI, weight gain until 20th week, significant risk from patient's history, cigarette smoking, risk pregnancy symptoms until 20th week), laboratory (maternal serum concentration of AFP, hCG, and uE3/triple test/at 16th week, the blood count and ferritin concentration at 18th-20th week, bacteriological cultivation of the smear from the cervix at 34th-36th week), and USG (transvaginal cervicometry and doppler flowmetry of the uterine arteries at 18th-20th week) data were established. With the aid of one-dimensional and multi-dimensional analysis the dependence of completed gestational age and preterm delivery (before completed 37th week) on above mentioned parameters was tested. RESULTS: 314 women completed the study. We proved a significant dependence of prematurity on the following markers: risk pregnancy symptoms until 20th week (RR 2.94), abnormal triple test (RR 4.63), cultivation of pathogens from the cervix (RR 5.49), USG established cervical length (P < 0.0001), abnormal result of cervicometry (RR 19.02), both doppler parameters (RI of uterine arteries: P < 0.0001; presence of early diastolic notch: RR 2.84). The results of multi-dimensional analysis confirmed superiority of USG cervicometry in prediction of both measured outcomes. CONCLUSION: The predictive value of some of selected anamnestic, laboratory, and USG markers of premature delivery was proved at random population of women with singleton pregnancy. The abnormal result of transvaginal USG cervicometry was the most significant predictor of prematurity. We recommend a routine performing of cervicometry (as a part of USG screening at 18th-20th week) for early selection of women with significantly increased risk of prematurity.

Článek

Príspĕvek ke klinické manifestaci rakoviny pankreatu. Retrospektivní studie
[Contribution on clinical manifestation of the cancer of the pancreas. Retrospective study (author's transl)]

Casopis lekaru ceskych. 1979 Sep 14 ; 118 (36-37) : 1109-12.

Cas Lek Cesk
ISSN 0008-7335
Zdroj

Článek

Bezpečnější antikoagulační léčba - použití idarucizumabu (Praxbind®): série kazuistik ze studie RE-VERSE AD a klinické praxe
[More safe anticoagulant treatment - use of idarucizumab (Praxbind®): case reports from RE-VERSE AD study and clinical practice]

RE-VERSE AD, a prospective multicentric cohort study, examined the effect of idarucizumab on 2 cohorts ...

Vnitrni lekarstvi. 2018 Spring ; 64 (3) : 309-313.

Vnitr Lek
ISSN 0042-773X
Zdroj

RE-VERSE AD, a prospective multicentric cohort study, examined the effect of idarucizumab on 2 cohorts of patients anticoagulated with dabigatran - in cohort A in patients with uncontrollable or life threatening bleeding, in cohort B in patients who undergo acute surgery. Within the study patients were intravenously administered 5 g antidote divided into 2 doses per 2.5 g within 15 min to eliminate the anticoagulation effect of dabigatran. A series of case studies is presented to describe the use of idarucizumab within the RE-VERSE AD study and in clinical practice in the period of 2015-2016 at the University Hospital Hradec Králové. The included examples illustrate the benefit of dabigatran as the only drug so far from the group of direct oral anticoagulants which has an antidote.Key words: antidote - bleeding - dabigatran - direct oral anticoagulants - DOAC - high risk of bleeding - idarucizumab - intervention.