• MeSH
• extraverze (psychologie) MeSH
• individualita MeSH
• introverze (psychologie) MeSH
• klasické podmiňování * MeSH
• lidé MeSH
• osobnost * MeSH
• podmiňování (oční víčka) MeSH
• psychotické poruchy psychologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

An effect of parasites on host behaviour was tested on the toxoplasma-human model. Three hundred and thirty-eight (338) people were assessed with Cattell's personality questionnaire and then tested for Toxoplasma gondii infection with a delayed type hypersensitivity test for Toxoplasma. A highly significant correlation between chronic toxoplasmosis and two personality factors (G-Low Superego Strength and L-Protension) was found (p = 0.0032 and 0.0020, respectively). A correlation of the intensity of the personality factor-shifts with the duration of the infection (estimated from antibody titer) suggests that toxoplasmosis induces the shift in human personality, rather than the personality factors G and L influence an acquisition rate of Toxoplasma gondii infection.

• MeSH
• Catellův osobnostní dotazník 16PF MeSH
• chronická nemoc MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• osobnost * MeSH
• pozdní přecitlivělost MeSH
• protilátky protozoální krev   MeSH
• senioři MeSH
• sexuální faktory MeSH
• Toxoplasma imunologie   MeSH
• toxoplazmóza diagnóza   imunologie   psychologie   MeSH
• zvířata MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• protilátky protozoální MeSH

The fludarabine (FLU)/melphalan (MEL) conditioning regimen containing FLU and high-dose MEL was analyzed in comparison with the BU/CY2 regimen to characterize oral mucositis (OM) and risk factors. OM incidence significantly varied between BU/CY2 and FLU/MEL (100 vs 78%, P=0.004), but the incidence of severe OM grades 3-4 WHO and kinetics of OM were fully comparable. Patients with OM persisting on day +21 had more acute GVHD (68 vs 32%, P=0.005), which tended to occur earlier than among those without such prolonged OM. Multivariate analysis showed significant dependency of acute GVHD on severity and prolonged duration of OM and significant correlation between OM severity and its prolonged duration. Body surface area-based dosing in the FLU/MEL regimen led to a wide range of MEL doses administered per kilogram body weight (2.5-5.2 mg/kg, median 3.5). In multivariate analysis, MEL dose per kilogram of body weight was found to be a significant predictor of OM incidence and severity. Female gender and lower body mass index were less important variables than the fact that the actual dose of MEL administered per kilogram of body weight was relatively high when the dosage was calculated on the basis of body surface area.

• MeSH
• alkylační protinádorové látky aplikace a dávkování   škodlivé účinky   MeSH
• busulfan aplikace a dávkování   MeSH
• cyklofosfamid aplikace a dávkování   MeSH
• dospělí MeSH
• incidence MeSH
• lidé středního věku MeSH
• lidé MeSH
• melfalan aplikace a dávkování   škodlivé účinky   MeSH
• mladý dospělý MeSH
• příprava pacienta k transplantaci škodlivé účinky   metody   MeSH
• prospektivní studie MeSH
• rizikové faktory MeSH
• senioři MeSH
• stomatitida chemicky indukované   etiologie   MeSH
• transplantace hematopoetických kmenových buněk škodlivé účinky   MeSH
• vidarabin aplikace a dávkování   škodlivé účinky   analogy a deriváty   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• alkylační protinádorové látky MeSH
• busulfan MeSH
• cyklofosfamid MeSH
• fludarabine MeSH Prohlížeč
• melfalan MeSH
• vidarabin MeSH

Temperaments are often regarded as biologically based psychological tendencies with intrinsic paths of development. It is argued that this definition applies to the personality traits of the five-factor model. Evidence for the endogenous nature of traits is summarized from studies of behavior genetics, parent-child relations, personality structure, animal personality, and the longitudinal stability of individual differences. New evidence for intrinsic maturation is offered from analyses of NEO Five-Factor Inventory scores for men and women age 14 and over in German, British, Spanish, Czech, and Turkish samples (N = 5,085). These data support strong conceptual links to child temperament despite modest empirical associations. The intrinsic maturation of personality is complemented by the culturally conditioned development of characteristic adaptations that express personality; interventions in human development are best addressed to these.

• MeSH
• behaviorální genetika MeSH
• dospělí MeSH
• kulturní charakteristiky * MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• osobnost * MeSH
• psychologické modely MeSH
• psychologické testy MeSH
• rozvoj osobnosti * MeSH
• srovnání kultur MeSH
• temperament * MeSH
• věkové faktory MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH
• Německo MeSH
• Španělsko MeSH
• Spojené království MeSH
• Turecko MeSH

BACKGROUND: Borderline personality disorder (BPD) is a disabling psychiatric condition with a chronic and challenging course. BPD is reflected as a disorder of self-regulation" and is associated with both psychological vulnerabilities and social relations that fail to support basic emotional needs. The objective of the paper is to provide the up-to-date data on the unmet needs of BPD patients and their families. METHOD: A computerized search of the literature printed between January 1990 and May 2017 was conducted in PubMed, and additional papers were extracted using keywords "borderline personality disorder,"needs," "pharmacotherapy," "psychotherapy," "CBT," and "family" in various combinations. According to the eligibility criteria, 57 articles were chosen. Secondary articles from the reference lists of primarily identified papers have been selected for the eligibility and added to the first list (N=151). RESULTS: The results were divided into three categories: the needs connected with (1) the symptom control; (2) the treatment; (3) the quality of life. The needs connected with symptoms were described issues such as emotional needs, social interactions, self-harm, parasuicide, suicidality, comorbidity, mentalization, identity disturbance, moreover, barriers to treatment. The needs connected with the treatment described are focused on needs for early diagnosis, early intervention, holding environment, therapeutic relation, assertive community treatment, destigmatization, hospitalization, and primary care. The needs connected with the quality of life involve family needs, physical health, spiritual needs, advocacy needs, and needs for the separation-individuation. The part focused on implications for the treatment presented several treatment approaches, focusing mostly on the their basics and efficacy. CONCLUSION: Observing the patients' needs may be essential to the treatment of the individuals suffering from BPD. However, many needs remain unmet in the areas linked to medical, personal, and social factors. A bigger focus on the patients' needs could be beneficial and should be targeted in the treatment.

• MeSH
• emoce fyziologie   MeSH
• hraniční porucha osobnosti psychologie   terapie   MeSH
• interpersonální vztahy * MeSH
• kvalita života psychologie   MeSH
• lidé MeSH
• psychoterapie metody   MeSH
• společenské stigma MeSH
• zdravotnické služby - potřeby a požadavky * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Relation between mental strain defined as heart rate deviation score from person's baseline and persistence-excitation concept based on the Eysenck personality theory under various density information flow was investigated. Two groups the HPE(high EPQ-N and low EPQ-E score) and the LPE(low EPQ-N and high EPQ-E score) of a nuclear power plant operators were investigated under a monotonous condition (HPE: 15 Ss; LPE:12 Ss) and under a high density information flow condition (HPE: 17Ss, LPE: 15 Ss). The data support the view that the high persistence-low inhibition individual will be more mentally strained under high density information flow and that the level of strain will decelerate more slowly in comparison to persons with low persistence-high inhibition EPQ characteristics. The low persistence-high inhibition individuals will experience higher mental strain under monotonous situations. The findings suggest that the average EPQ-E and EPQ-N score might be useful criterion for selecting persons for tasks with alternatively monotonous and cognitively demanding situations.

• MeSH
• arousal fyziologie   MeSH
• dospělí MeSH
• extraverze (psychologie) * MeSH
• introverze (psychologie) * MeSH
• lidé MeSH
• psychický stres patofyziologie   MeSH
• rozhodování MeSH
• srdeční frekvence * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

PURPOSE: The optimal dose intensity for conditioning prior to allogeneic hematopoietic stem cell transplantation (alloHSCT) for chronic lymphocytic leukemia (CLL) is unknown. METHODS: We retrospectively compared outcomes of patients who received a first alloHCST after non-myeloablative (NMA) and reduced intensity conditioning (RIC). Data of 432 patients with a median age of 55 years were included, of which 86 patients underwent NMA and 346 RIC. RESULTS: The median follow-up after alloHSCT was 4.3 years. Compared to the RIC group, more NMA patients had purine-analog-sensitive disease, were in complete remission and received matched related donor transplantation. After RIC, the probabilities for 5-year OS, EFS, CIR, and NRM were 46%, 38%, 28%, and 35% and after NMA the respective probabilities were 52%, 43%, 25%, and 32%. In multivariate analysis, remission status prior to conditioning but not RIC versus NMA conditioning had a significant impact on CIR, EFS, and OS. CONCLUSION: Presumed higher anti-leukemic activity of RIC versus NMA conditioning did not translate into better outcomes after alloHSCT, but better remission status prior to conditioning did. Effective pathway inhibitor-based salvage therapies combined with NMA conditioning might thus represent the most attractive contemporary approach for alloHSCT for patients with CLL.

• Klíčová slova
• Allogeneic hematopoietic stem cell transplantation, Nonmyeloablative/reduced intensity conditioning, Relapsed/refractory chronic lymphocytic leukemia,
• MeSH
• busulfan aplikace a dávkování   MeSH
• chronická lymfatická leukemie mortalita   patologie   terapie   MeSH
• cyklofosfamid aplikace a dávkování   MeSH
• dospělí MeSH
• homologní transplantace MeSH
• incidence MeSH
• indukce remise MeSH
• kombinovaná terapie MeSH
• lidé středního věku MeSH
• lidé MeSH
• melfalan aplikace a dávkování   MeSH
• míra přežití MeSH
• mladý dospělý MeSH
• následné studie MeSH
• nemoc štěpu proti hostiteli epidemiologie   mortalita   MeSH
• příprava pacienta k transplantaci mortalita   MeSH
• prognóza MeSH
• protokoly protinádorové kombinované chemoterapie terapeutické užití   MeSH
• retrospektivní studie MeSH
• senioři MeSH
• transplantace hematopoetických kmenových buněk mortalita   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• busulfan MeSH
• cyklofosfamid MeSH
• melfalan MeSH

Background Stomach preparation by ischaemic conditioning prior to oesophageal resection represents a potential method of reducing the risk of anastomotic complications. This study compares the results of the anastomotic complications of cervical anastomosis after oesophagectomy with a short interval after ischaemic conditioning (group S) and a long interval (group L). Methods Subjects undergoing oesophagectomy for carcinoma after ischaemic conditioning were divided into two groups. Group S had a median interval between ischaemic conditioning and resection of 20 days, while for group L the median interval was 49 days. Anastomotic leak and anastomotic stenosis in relation to the interval between ischaemic conditioning and actual resection were followed. Results After ischaemic conditioning, 33 subjects in total underwent surgery for carcinoma; 19 subjects in group S and 14 subjects in group L. Anastomotic leak incidence was comparable in both groups. Anastomotic stenosis occurred in 21% of cases in group S and 7% of cases in group L (not statistically significant). Conclusions A long interval between ischaemic conditioning and oesophagectomy does not adversely affect the postoperative complications. A lower incidence of anastomosis stenoses was found in subjects with a longer interval, however, given the size of our sample, the statistical significance was not demonstrated. Both groups seem comparable in surgical procedure course and postoperative complications.

• Klíčová slova
• Anastomotic leak, Anastomotic stenosis, Minimally invasive oesophagectomy, Oesophageal carcinoma, Stomach ischaemic conditioning,
• MeSH
• anastomóza chirurgická škodlivé účinky   metody   MeSH
• časové faktory MeSH
• dospělí MeSH
• ezofagektomie škodlivé účinky   MeSH
• incidence MeSH
• lidé středního věku MeSH
• lidé MeSH
• miniinvazivní chirurgické výkony škodlivé účinky   metody   MeSH
• nádory jícnu chirurgie   MeSH
• netěsnost anastomózy epidemiologie   etiologie   MeSH
• přivykání k ischémii škodlivé účinky   metody   MeSH
• senioři MeSH
• stenóza epidemiologie   etiologie   MeSH
• žaludek chirurgie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH

The aims of this study were to investigate the associations between work stress defined by the effort-reward imbalance (ERI) model and diet quality and to examine the potential role of over-commitment (OC) personality in ERI-diet relationships. A cross-sectional study was conducted in random population samples of 6340 men and 5792 women (age 45-69 years) from the Czech Republic, Russia and Poland. Dietary data were collected using FFQ. The healthy diet indicator (HDI) was constructed using eight nutrient/food intakes (HDI components) to reflect the adherence to WHO dietary guideline. The extent of imbalance between effort and reward was measured by the effort:reward (ER) ratio; the effort score was the numerator and the reward score was multiplied by a factor adjusting for unequal number of items in the denominator. Logistic regression and linear regression were used to assess the associations between exposures (ER ratio and OC) and outcomes (HDI components and HDI) after adjustment for confounders and mediators. The results showed that high ER ratio and high OC were significantly associated with unhealthy diet quality. For a 1-SD increase in the ER ratio, HDI was reduced by 0·030 and 0·033 sd in men and women, and for a 1-SD increase in OC, HDI was decreased by 0·036 and 0·032 sd in men and women, respectively. The modifying role of OC in ERI-diet relationships was non-significant. To improve diet quality at workplace, a multiple-level approach combining organisational intervention for work stress and individual intervention for vulnerable personality is recommended.

• Klíčová slova
• Alcohol and Psychosocial factors In Eastern Europe, CEE Central and Eastern European, Diet, ERI effort–reward imbalance, Effort–reward imbalance, HAPIEE Health, HDI healthy diet indicator, OC over-commitment, Over-commitment, Personality, Work stress,
• MeSH
• dieta * MeSH
• dietní záznamy MeSH
• lidé středního věku MeSH
• lidé MeSH
• nutriční hodnota MeSH
• odměna MeSH
• osobnost fyziologie   MeSH
• práce fyziologie   psychologie   MeSH
• průřezové studie MeSH
• průzkumy a dotazníky MeSH
• psychický stres MeSH
• senioři MeSH
• stravovací zvyklosti MeSH
• Světová zdravotnická organizace MeSH
• výživová politika MeSH
• zdravé chování MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, N.I.H., Extramural MeSH
• Geografické názvy
• Česká republika MeSH
• Polsko MeSH
• Rusko MeSH
• východní Evropa MeSH

• MeSH
• charakteristiky rodiny MeSH
• duševní poruchy patofyziologie   MeSH
• emigrace a imigrace MeSH
• klasické podmiňování MeSH
• lidé MeSH
• neurotické poruchy patofyziologie   MeSH
• poruchy osobnosti patofyziologie   MeSH
• reakční čas MeSH
• schizofrenie patofyziologie   MeSH
• sexuální faktory MeSH
• socioekonomické faktory * MeSH
• společenská třída MeSH
• srdeční frekvence MeSH
• stupeň vzdělání MeSH
• testy slovních asociací MeSH
• věkové faktory MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH