• Keywords
• ARTERIOSCLEROSIS *, BLOOD CHOLESTEROL *, LIPOPROTEINS *, PHOSPHOLIPIDS *,
• MeSH
• Arteriosclerosis * MeSH
• Atherosclerosis * MeSH
• Cholesterol blood   MeSH
• Phospholipids * MeSH
• Lipids * MeSH
• Lipoproteins * MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Cholesterol MeSH
• Phospholipids * MeSH
• Lipids * MeSH
• Lipoproteins * MeSH

• MeSH
• Analysis of Variance MeSH
• Aorta analysis   MeSH
• Arteriosclerosis metabolism   MeSH
• Blood Vessels metabolism   MeSH
• Cholesterol analysis   blood   MeSH
• Liver metabolism   MeSH
• Rabbits MeSH
• Thioctic Acid pharmacology   MeSH
• Lipoproteins, LDL analysis   blood   MeSH
• Myocardium metabolism   MeSH
• Regression Analysis MeSH
• Oxygen Consumption drug effects   MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Cholesterol MeSH
• Thioctic Acid MeSH
• Lipoproteins, LDL MeSH

Bilirubin, a major intravascular product of heme catabolism, is a potent antioxidant compound. Numerous studies have been published showing the relationship between serum bilirubin levels and atherosclerosis. In the present investigation all the epidemiological studies available on the effect of serum bilirubin levels and atherosclerotic disease were analyzed. Studies on the epidemiology of atherosclerotic diseases in relation to serum bilirubin levels were searched in the MEDLINE database. Selected studies were subdivided according to serum bilirubin levels and severity of atherosclerotic disease. Because of the limited number of females involved in the studies, only males were included into meta-analysis. Associations for ordered categorical variables (bilirubin and natural history of graded atherosclerosis) were assessed to find correlation and linear trend between analyzed variables. A stratified analysis was conducted to compare risks of clinical outcomes. Eleven relevant studies were used for analysis. A close negative relationship was found between serum bilirubin levels and severity of atherosclerosis (Spearman rank coefficient r = -0.31,P < 0.0001). The linear trend was confirmed in analysis of proportions with x(2) values for both disease conditions to be very significant (P < 0.0001). Unambiguous inverse relationship between serum bilirubin levels and atherosclerosis was demonstrated in this preliminary meta-analytic study. These results indicate the importance of hem oxygenase-related products in the prevention of oxidative stress-mediated diseases.

• MeSH
• Arteriosclerosis metabolism   MeSH
• Bilirubin blood   MeSH
• Epidemiologic Studies MeSH
• Humans MeSH
• MEDLINE MeSH
• Regression Analysis MeSH
• Risk Factors MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Publication type
• Journal Article MeSH
• Meta-Analysis MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Bilirubin MeSH

• MeSH
• Aorta enzymology   MeSH
• Arteriosclerosis enzymology   MeSH
• Diet, Atherogenic MeSH
• Esterases metabolism   MeSH
• Histocytochemistry MeSH
• Rabbits MeSH
• Lipase metabolism   MeSH
• Lipid Metabolism * MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Esterases MeSH
• Lipase MeSH

In experiments on guinea pigs with experimental atherosclerosis, vanadium pentoxide retarded the development of vascular pathomorphological changes, supported cholesterol metabolism, and activated oxidoreductive processes. Correlation and regression analyses proved that vanadium pentoxide has a beneficial effect on the course of experimental atherosclerosis in guinea pigs to the influence of this drug on oxido-reductive processes.

• MeSH
• Arteriosclerosis metabolism   MeSH
• Blood Vessels metabolism   MeSH
• Cholesterol, Dietary metabolism   MeSH
• Cholesterol metabolism   MeSH
• Liver metabolism   MeSH
• Guinea Pigs MeSH
• Myocardium metabolism   MeSH
• Oxidation-Reduction drug effects   MeSH
• Regression Analysis MeSH
• Oxygen Consumption drug effects   MeSH
• Vanadium pharmacology   MeSH
• Animals MeSH
• Check Tag
• Guinea Pigs MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Cholesterol, Dietary MeSH
• Cholesterol MeSH
• Vanadium MeSH

• Keywords
• AORTA *, ARTERIOSCLEROSIS *, CARBON ISOTOPES *, CHOLESTEROL *, CORTISONE *, EXPERIMENTAL LAB STUDY *, HYPERCHOLESTEREMIA *, PERMEABILITY *, RABBITS *,
• MeSH
• Aorta * MeSH
• Arteriosclerosis * MeSH
• Atherosclerosis * MeSH
• Cholesterol * MeSH
• Hypercholesterolemia * MeSH
• Carbon Isotopes * MeSH
• Cortisone * MeSH
• Rabbits MeSH
• Permeability * MeSH
• Research * MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Cholesterol * MeSH
• Carbon Isotopes * MeSH
• Cortisone * MeSH

In recent years many scientific papers have been published concerning the positive effects of wine and its active principles, the polyphenol resveratrol being the most widely discussed compound. The results of epidemiological and experimental studies in man, animals, and in vitro have shown that polyphenols contained in wine, tea, fruit, and vegetables exert a positive effect on both the progression and regression of atherosclerosis, possess an anticancerogenic action, and due to their antioxidative effects they act against other processes connected with the reactive forms of oxygen production and lipid peroxydation in the blood plasma and membranes. Experimental findings have shown that resveratrol protects the cardiovascular system, affects lipid metabolism, and inhibits low-density lipoproteins (LDL) oxidation and blood platelet aggregation. In addition, this natural product is able to inhibit the growth of some tumours and possesses antiinflammatory properties and a number of other biological effects. This report aims to describe and characterize in a summary the biological properties of the principal active principles of wine--flavonoids and polyphenols, with a detailed focus on resveratrol, which has been described as the most interesting agent.

• MeSH
• Antioxidants pharmacology   MeSH
• Humans MeSH
• Resveratrol MeSH
• Stilbenes analysis   pharmacology   MeSH
• Wine * analysis   MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Antioxidants MeSH
• Resveratrol MeSH
• Stilbenes MeSH