CORTISONE
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A possible effect of mini-invasive heart intervention on a response of hypothalamo-pituitary-adrenal stress axis and conversion of cortisone to cortisol were studied. We have analysed two stress markers levels (cortisol, cortisone) and cortisol/cortisone ratio in 25 sows using minimally invasive heart catheterisation as the stress factor. The values of studied parameters were assessed in four periods of the experiment: (1) the baseline level on the day before intervention, (2) after the introduction of anaesthesia, (3) after conducting tissue stimulation or ablation, and (4) after the end of the catheterisation. For statistical analyses we used the non-parametric Friedman test for four dependent samples (including all four stages of the operation) or three dependent samples (influence of operation only, baseline level was excluded). Statistically significant differences in both Friedman tests were found for cortisol and for cortisone. We have found the highest level of cortisol/cortisone ratio in unstressed conditions, then it decreased to the minimal level at the end of the intervention. We have concluded that cortisol levels are blunted by the influence of anaesthesia after its administration, and therefore decrease back to the baseline at the end of the operation.
- Klíčová slova
- Cortisol/cortisone ratio, Heart catheterisation, Sow, Stress, Stress hormones,
- MeSH
- biologické markery krev MeSH
- fyziologický stres fyziologie MeSH
- hydrokortison krev MeSH
- kortison krev MeSH
- prasata MeSH
- srdeční katetrizace * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- hydrokortison MeSH
- kortison MeSH
- Klíčová slova
- ACTH/therapeutic use *, CORTISONE/therapeutic use *, EYE DISEASES/therapy *,
- MeSH
- adrenokortikotropní hormon terapeutické užití MeSH
- kortison terapeutické užití MeSH
- oční nemoci terapie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adrenokortikotropní hormon MeSH
- kortison MeSH
- Klíčová slova
- CORTISONE/therapy *, FALLOPIAN TUBES/diseases *, STERILITY, FEMALE/therapy *,
- MeSH
- infertilita * MeSH
- kortison terapie MeSH
- lidé MeSH
- nemoci vejcovodů * MeSH
- vejcovody * MeSH
- ženská infertilita terapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kortison MeSH
- Klíčová slova
- ADHESIONS/therapy *, CORTISONE/therapy *, URETHRA/diseases *,
- MeSH
- adheze tkání terapie MeSH
- kortison terapie MeSH
- lidé MeSH
- nemoc * MeSH
- stenóza MeSH
- uretra * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kortison MeSH
- Klíčová slova
- CORTISONE/therapy *, KNEE/pharmacology *, OSTEOARTHRITIS/therapy *, SPONDYLITIS, ANKYLOSING/therapy *,
- MeSH
- ankylózující spondylitida terapie MeSH
- koleno farmakologie MeSH
- kortison terapie MeSH
- lidé MeSH
- osteoartróza terapie MeSH
- spondylitida * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kortison MeSH
- Klíčová slova
- ARTHRITIS, RHEUMATOID *, CORTISONE *,
- MeSH
- artritida * MeSH
- kortison * MeSH
- revmatoidní artritida * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kortison * MeSH
- Klíčová slova
- BLOOD CHOLESTEROL *, CHOLESTEROL *, CORTISONE *, LIPOPROTEINS *,
- MeSH
- cholesterol krev MeSH
- kortison * MeSH
- lidé MeSH
- lipoproteiny * MeSH
- techniky in vitro MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cholesterol MeSH
- kortison * MeSH
- lipoproteiny * MeSH
Individual and combined effects of cortisone and insulin on the synthesis of beta-galactosidase in the strains E. coli K 12 200 PS/Flac and M-308 and the possiblity of cortisone uptake by the bacterial cell under different temperature conditions were investigated in their dynamics. When insulin and cortisone are applied simultaneously in doses showing individually the greatest stimulative effect on the synthesis of beat-galactosidase, no summation of the effect of the hormones occurs in the strain E. coli 200 PS/Flac in the presence of IPTG while in the strain E. coli ML-308 simultaneous application of insulin and cortisone induces a negligible increase in the activity of beta-galactosidase. Tests for the incorporation of [3H] cortisone into the strains E. coli 200 PS/Flac and ML-308 have shown that the hormone is taken up by the bacterial cell immediately after its addition to the incubation medium, reaching its maximum after 5 min of incubation and maintaining the same level in the subsequent 30 min. The incorporation of [3H] cortisone at a temperature of 37degrees C is markedly higher than at 4degrees C. Preliminary incubation of the cultures with unlabelled cortisone and insulin resulted in a decrease in the uptake of [3H] cortisone by the bacterial cell.
- MeSH
- enzymová indukce účinky léků MeSH
- Escherichia coli enzymologie metabolismus MeSH
- galaktosidasy biosyntéza MeSH
- inzulin farmakologie MeSH
- isopropylthiogalaktosid metabolismus MeSH
- kortison metabolismus farmakologie MeSH
- laktosa biosyntéza MeSH
- mutace MeSH
- operon MeSH
- teplota MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- galaktosidasy MeSH
- inzulin MeSH
- isopropylthiogalaktosid MeSH
- kortison MeSH
- laktosa MeSH
- Klíčová slova
- CORTISONE/pharmacology *, IMMUNE SERUMS/pharmacology *, NEOPLASMS/experimental *, POLYSACCHARIDES/pharmacology *,
- MeSH
- antisérum farmakologie MeSH
- experimentální nádory * MeSH
- kortison farmakologie MeSH
- křečci praví MeSH
- polysacharidy farmakologie MeSH
- zvířata MeSH
- zymosan * MeSH
- Check Tag
- křečci praví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antisérum MeSH
- kortison MeSH
- polysacharidy MeSH
- zymosan * MeSH
- Klíčová slova
- CORTISONE/pharmacology *, THYROID GLAND/transplantation *,
- MeSH
- homologní transplantace * MeSH
- kortison farmakologie MeSH
- krysa rodu Rattus MeSH
- štítná žláza transplantace MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kortison MeSH