Studie je zaměřena na asociaci mezi T-buněčnými lymfomy kožními a některými předpokládanými složkami genetického základu organismu, jež mohou participovat na vzniku těchto kožních T-buněčných lymfomů.

The study was focused on an association between T-cell lymphoma and some supposed components of genetic background of the organism which could participate in the onset of cutaneous T-cell lymphomas. Polymorphisms of angiotensin I-converting enzyme (I/D ACE, intron 16) and lymphotoxin a (TNFP) (NCol in intron I) genes were investigated in 33 Caucasian patients with cutaneous T-cell lymphomas and 66 healthy subjects. The polymorphisms were detected by poljnnerase chain reaction-based methods and restriction enzyme analysis. No differences were found in the allelic frequencies of he polymorphisms between patients and control subjects. In patients with T-cell lymphoma, a concurrence of the DD genotype of I/D ACE with the Bl allele of the TNFp gene was found (n = 2/24,8 % in controls vs. n = 8/18,44 % in CTCL; P = 0.009, odds ratio - 8.80,95% confidence interval 1.50-51.50). The DD homozygote together with the TNFP heterozygote genotype (B1B2) was found to be the highest risk genotype for T-cell lymphoma patients (n x 2/12,17 % in controls and 8/9, 89 % in CTCL; P = 0.002, odds ratio 40.00,95% confidence interval 1.56-1024.12).

1 dermatovenerol klinika FN U sv Anny Brno

Some genetic aspects of cutaneous T-cell lymphomas

Některé genetické aspekty kožních T-lymfomů = Some genetic aspects of cutaneous T-cell lymphomas /

Some genetic aspects of cutaneous T-cell lymphomas /

Lit: 24

Souhrn: eng