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Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma
Šůsová S, Trněný M, Souček P.
Jazyk angličtina Země Irsko
Grantová podpora
NR8563
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
NLK
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
- MeSH
- 5' přiléhající oblast DNA genetika MeSH
- DNA vazebné proteiny genetika MeSH
- financování organizované MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- nehodgkinský lymfom diagnóza genetika MeSH
- prognóza MeSH
- riziko MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
Mutations in the 5'-regulatory region of BCL6 were suggested to play a role in non-Hodgkin's lymphoma (NHL) progression and in the transformation of follicular lymphoma to more aggressive diffuse large B-cell type. The aim of this study was to explore association between polymorphism G397C in the 5'-region of BCL6 and both incidence and progression of NHL in 154 NHL cases and 362 controls. Neither frequencies of the rare BCL6 allele 397C nor particular genotypes differed significantly between NHL cases and controls. There was no significant association of histological type of NHL and clinical characteristics with this polymorphism.
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- $a Mutations in the 5'-regulatory region of BCL6 were suggested to play a role in non-Hodgkin's lymphoma (NHL) progression and in the transformation of follicular lymphoma to more aggressive diffuse large B-cell type. The aim of this study was to explore association between polymorphism G397C in the 5'-region of BCL6 and both incidence and progression of NHL in 154 NHL cases and 362 controls. Neither frequencies of the rare BCL6 allele 397C nor particular genotypes differed significantly between NHL cases and controls. There was no significant association of histological type of NHL and clinical characteristics with this polymorphism.
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