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Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma
Šůsová S, Trněný M, Souček P.
Language English Country Ireland
Grant support
NR8563
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- 5' Flanking Region genetics MeSH
- DNA-Binding Proteins genetics MeSH
- Financing, Organized MeSH
- Polymorphism, Single Nucleotide MeSH
- Humans MeSH
- Lymphoma, Non-Hodgkin diagnosis genetics MeSH
- Prognosis MeSH
- Risk MeSH
- Risk Factors MeSH
- Check Tag
- Humans MeSH
Mutations in the 5'-regulatory region of BCL6 were suggested to play a role in non-Hodgkin's lymphoma (NHL) progression and in the transformation of follicular lymphoma to more aggressive diffuse large B-cell type. The aim of this study was to explore association between polymorphism G397C in the 5'-region of BCL6 and both incidence and progression of NHL in 154 NHL cases and 362 controls. Neither frequencies of the rare BCL6 allele 397C nor particular genotypes differed significantly between NHL cases and controls. There was no significant association of histological type of NHL and clinical characteristics with this polymorphism.
References provided by Crossref.org
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- $a Biotransformations Group, National Institute of Public Health, Centre of Occupational Diseases, Srobárova 48, Prague 10, 100 42, Czech Republic
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