-
Je něco špatně v tomto záznamu ?
Association of DNA adducts and genotypes with birth weight
Sram RJ, Binkova B, Dejmek J, Chvatalova I, Solansky I, Topinka J.
Jazyk angličtina Země Nizozemsko
- MeSH
- adukty DNA analýza genetika MeSH
- alely MeSH
- cytochrom P-450 CYP1A1 genetika MeSH
- dospělí MeSH
- financování organizované MeSH
- genotyp MeSH
- gestační stáří MeSH
- glutathion-S-transferasa fí genetika MeSH
- glutathiontransferasa genetika MeSH
- kouření škodlivé účinky MeSH
- lidé MeSH
- novorozenec nedonošený MeSH
- novorozenec s nízkou porodní hmotností MeSH
- novorozenec MeSH
- polymorfismus genetický MeSH
- porodní hmotnost genetika MeSH
- studie případů a kontrol MeSH
- těhotenství MeSH
- znečištění ovzduší analýza škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Česká republika MeSH
The relationships between DNA adducts and birth weight and between birth weight and genetic polymorphisms of metabolic genotypes were studied using DNA from the children part of placental samples. The samples were collected in the districts of Teplice and Prachatice and in the city of Prague. DNA adducts were analyzed by (32)P-postlabeling in a total of 199 subjects, genetic polymorphisms in 1013 subjects. GSTM1, GSTP1, GSTT1, CYP1A1*2A, and CYP1A1*2C genotypes were determined for each subject. The level of DNA adducts was not correlated with birth weight in any group (N=199), including that from the polluted district of Teplice (N=90). Birth weight was significantly decreased by smoking, ETS and alleles of CYP1A1*2C. The risk of low birth weight and prematurity was significantly increased by genotypes of GSTM1 and CYP1A1*2C and the combination GSTM1+CYP1A1*2A. Genotypes are primarily effect modifiers, whose effect incorporates the effect of environmental factors. This means that in the future, the impact of air pollution on children's health should be studied together with their genetic polymorphisms.
- 000
- 00000naa 2200000 a 4500
- 001
- bmc07523578
- 003
- CZ-PrNML
- 005
- 20111210140000.0
- 008
- 090520s2006 ne e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Šrám, Radim J., $d 1939- $7 jk01130963
- 245 10
- $a Association of DNA adducts and genotypes with birth weight / $c Sram RJ, Binkova B, Dejmek J, Chvatalova I, Solansky I, Topinka J.
- 314 __
- $a Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, AS CR, Vídenská 1083, 142 20 Prague, Czech Republic. sram@biomed.cas.cz
- 520 9_
- $a The relationships between DNA adducts and birth weight and between birth weight and genetic polymorphisms of metabolic genotypes were studied using DNA from the children part of placental samples. The samples were collected in the districts of Teplice and Prachatice and in the city of Prague. DNA adducts were analyzed by (32)P-postlabeling in a total of 199 subjects, genetic polymorphisms in 1013 subjects. GSTM1, GSTP1, GSTT1, CYP1A1*2A, and CYP1A1*2C genotypes were determined for each subject. The level of DNA adducts was not correlated with birth weight in any group (N=199), including that from the polluted district of Teplice (N=90). Birth weight was significantly decreased by smoking, ETS and alleles of CYP1A1*2C. The risk of low birth weight and prematurity was significantly increased by genotypes of GSTM1 and CYP1A1*2C and the combination GSTM1+CYP1A1*2A. Genotypes are primarily effect modifiers, whose effect incorporates the effect of environmental factors. This means that in the future, the impact of air pollution on children's health should be studied together with their genetic polymorphisms.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a znečištění ovzduší $x analýza $x škodlivé účinky $7 D000397
- 650 _2
- $a alely $7 D000483
- 650 _2
- $a porodní hmotnost $x genetika $7 D001724
- 650 _2
- $a studie případů a kontrol $7 D016022
- 650 _2
- $a cytochrom P-450 CYP1A1 $x genetika $7 D019363
- 650 _2
- $a adukty DNA $x analýza $x genetika $7 D018736
- 650 _2
- $a gestační stáří $7 D005865
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a genotyp $7 D005838
- 650 _2
- $a glutathion-S-transferasa fí $x genetika $7 D051549
- 650 _2
- $a glutathiontransferasa $x genetika $7 D005982
- 650 _2
- $a novorozenec s nízkou porodní hmotností $7 D007230
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a novorozenec $7 D007231
- 650 _2
- $a novorozenec nedonošený $7 D007234
- 650 _2
- $a polymorfismus genetický $7 D011110
- 650 _2
- $a těhotenství $7 D011247
- 650 _2
- $a kouření $x škodlivé účinky $7 D012907
- 650 _2
- $a financování organizované $7 D005381
- 651 _2
- $a Česká republika $7 D018153
- 700 1_
- $a Binková, Blanka $7 xx0104124
- 700 1_
- $a Dejmek, Jan, $d -2002 $7 xx0063708
- 700 1_
- $a Chvátalová, Irena $7 xx0140380
- 700 1_
- $a Solanský, Ivo $7 xx0094799
- 700 1_
- $a Topinka, Jan, $d 1955- $7 mzk2006322846
- 773 0_
- $w MED00003430 $t Mutation research. [All sections] $g Roč. 608, č. 2 (2006), s. 121-128 $x 0027-5107
- 910 __
- $a ABA008 $b B 1575 $y 9
- 990 __
- $a 20090519102933 $b ABA008
- 991 __
- $a 20111101110351 $b ABA008
- 999 __
- $a ok $b bmc $g 656654 $s 509971
- BAS __
- $a 3
- BMC __
- $a 2006 $b 608 $c 2 $d 121-128 $i 0027-5107 $m Mutation research $x MED00003430
- LZP __
- $a 2009-B2/dkme
