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Antidiabetic properties of S-allyl cysteine, a garlic component on Streptozotocin-induced diabetes in rats
Ganapathy Saravanan, Ponnusamy Ponmurugan, Gandhipuram Periyasamy Senthil Kumar, Thatchinamoorthi Rajarajan
Jazyk angličtina Země Česko
Typ dokumentu tabulky
NLK
Free Medical Journals
od 2003 do 2013
Freely Accessible Science Journals
od 2003 do 2013
ROAD: Directory of Open Access Scholarly Resources
od 2002
- MeSH
- česnek chemie MeSH
- cystein analogy a deriváty izolace a purifikace terapeutické užití MeSH
- diabetes mellitus farmakoterapie prevence a kontrola MeSH
- ELISA metody využití MeSH
- experimenty na zvířatech MeSH
- hypoglykemika metabolismus terapeutické užití MeSH
- krevní glukóza účinky léků MeSH
- potkani Wistar MeSH
- rostlinné extrakty izolace a purifikace metabolismus terapeutické užití MeSH
- streptozocin aplikace a dávkování škodlivé účinky MeSH
- tělesná hmotnost MeSH
- transaminasy krev účinky léků MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- tabulky MeSH
The present study was carried out to investigate the hypoglycaemic effect of S-allyl cysteine (SAC), a garlic component, on some biochemical parameters of STZ induced diabetic rats. STZ induced diabetic rats were treated with SAC at two different doses (100 mg/kg b.w. and 150 mg/kg b.w.) for 45 days. Treatment with SAC significantly decreased the levels of blood glucose, glycosylated hemoglobin, blood urea, serum uric acid, serum creatinine, and diminished activities of pathophysiological enzymes such as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP). The antihyperglycaemic nature of SAC is also evidenced from the improvement in the levels of plasma insulin and haemoglobin. Further, the results are comparable with glyclazide, an oral standard drug. A 150 mg/kg b.w. dose produced a better effect than a 100 mg dose. Thus, the present findings suggest that SAC may be considered as an effective therapeutic agent for the treatment of diabetes mellitus.
Citace poskytuje Crossref.org
Lit.: 56
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- $a The present study was carried out to investigate the hypoglycaemic effect of S-allyl cysteine (SAC), a garlic component, on some biochemical parameters of STZ induced diabetic rats. STZ induced diabetic rats were treated with SAC at two different doses (100 mg/kg b.w. and 150 mg/kg b.w.) for 45 days. Treatment with SAC significantly decreased the levels of blood glucose, glycosylated hemoglobin, blood urea, serum uric acid, serum creatinine, and diminished activities of pathophysiological enzymes such as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP). The antihyperglycaemic nature of SAC is also evidenced from the improvement in the levels of plasma insulin and haemoglobin. Further, the results are comparable with glyclazide, an oral standard drug. A 150 mg/kg b.w. dose produced a better effect than a 100 mg dose. Thus, the present findings suggest that SAC may be considered as an effective therapeutic agent for the treatment of diabetes mellitus.
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