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Polymerové mikročástice pro perorální přívod diklofenaku
[Polymeric microparticles for oral administration of diclofenac sodium]
Kateřina Krejčová, Eva Gryczová, Miloslava Rabišková
Language Czech Country Czech Republic
- MeSH
- Administration, Oral MeSH
- Diclofenac administration & dosage pharmacokinetics pharmacology MeSH
- Microscopy, Electron methods utilization MeSH
- Emulsions MeSH
- Drug Industry methods trends MeSH
- Gastrointestinal Tract drug effects MeSH
- Clinical Laboratory Techniques instrumentation utilization MeSH
- Dosage Forms MeSH
- Delayed-Action Preparations pharmacokinetics pharmacology MeSH
- Humans MeSH
- Methanol MeSH
- Methylmethacrylates pharmacokinetics pharmacology MeSH
- Microchemistry history methods MeSH
- Drug Carriers pharmacokinetics pharmacology MeSH
- Polymers therapeutic use MeSH
- Solubility MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
Microparticles are an intensively studied field of pharmaceutical technology. Reduced side effects and new drug delivery methods are some of the advantages they offer. The aim of this study was to develop and optimize the preparation of Eudragit® RS 100 microparticles containing diclofenac sodium. The emulsification - solvent evaporation method is one of the most common and widely used microencapsulation techniques. The influence of few selected processes and formulation variables on the microparticle characteristics was investigated for the emulsion of methanol in liquid paraffin. The following conditions were selected: polymer-to-drug ratio 2:1, emulsification with 1% Span® 80 at 19000 rpm and 40 °C. The dissolution of the drug from microparticles was controlled by diffusion.
Polymeric microparticles for oral administration of diclofenac sodium
Lit.: 17
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- $a Polymeric microparticles for oral administration of diclofenac sodium
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- $a Ústav technologie léků, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno
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- $a Lit.: 17
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- $a Microparticles are an intensively studied field of pharmaceutical technology. Reduced side effects and new drug delivery methods are some of the advantages they offer. The aim of this study was to develop and optimize the preparation of Eudragit® RS 100 microparticles containing diclofenac sodium. The emulsification - solvent evaporation method is one of the most common and widely used microencapsulation techniques. The influence of few selected processes and formulation variables on the microparticle characteristics was investigated for the emulsion of methanol in liquid paraffin. The following conditions were selected: polymer-to-drug ratio 2:1, emulsification with 1% Span® 80 at 19000 rpm and 40 °C. The dissolution of the drug from microparticles was controlled by diffusion.
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