-
Je něco špatně v tomto záznamu ?
Dynamic monitoring of cardio-specific markers and markers of thyroid gland function in cancer patients--a pilot study
Holubec L Jr, Topolcan O, Finek J, Salvet J, Svoboda T, Svobodova S, Mrazkova P, Ludvikova M
Jazyk angličtina Země Řecko
E-zdroje NLK Online
Free Medical Journals od 2004 do Před 2 rokyOpen Access Digital Library od 2004-01-01
- MeSH
- adjuvantní chemoterapie škodlivé účinky MeSH
- dospělí MeSH
- financování organizované MeSH
- fluorouracil aplikace a dávkování škodlivé účinky MeSH
- ischemická choroba srdeční chemicky indukované MeSH
- kolorektální nádory farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- natriuretický peptid typu B účinky léků MeSH
- paliativní péče MeSH
- pilotní projekty MeSH
- protokoly antitumorózní kombinované chemoterapie škodlivé účinky MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- srdce účinky léků MeSH
- srdeční selhání chemicky indukované MeSH
- štítná žláza účinky léků MeSH
- thyreotropin účinky léků MeSH
- thyroxin účinky léků MeSH
- troponin I škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
BACKGROUND: With the increased effectiveness of anticancer therapy, much more attention is being paid to the monitoring of the side-effects of chemotherapy, which often constitute a limiting factor in anticancer therapy. In this pilot study, the results of our monitoring of changes in cardio-specific markers and thyroid gland parameters in patients with colorectal carcinoma in the course of adjuvant and palliative chemotherapy are presented. PATIENTS AND METHODS: A total of 42 patients with colorectal carcinoma were monitored (median age 52 years, range 34-82 years); in these patients a post-operative adjuvant or palliative chemotherapy was applied (de Gramont's or FOLFIRI regimen). In all of these patients, the cardio-specific markers brain natriuretic peptide (BNP) and troponin I were assessed, as well as markers of thyroid gland function, TSH and FT4. RESULTS: In the course of chemotherapy, more than half of the patients showed laboratory signs of coronary ischemia; in 6 of these (14%) coronary ischemia was manifested with troponin I levels above 0.3 microg/L. Twenty patients (48%) had laboratory signs of heart failure in the course of adjuvant or palliative chemotherapy. A more frequent incidence of elevated cardio-specific enzymes was observed in continual regimens than in bolus application of fluorouracil. Reduced TSH values were observed in the course of chemotherapy in 9 patients (21%), without changes in FT4 values. An increase in TSH values was observed in 4 patients (10%), again without changes in FT4 values. CONCLUSION: The pilot study demonstrated that in patients undergoing treatment for colorectal carcinoma by adjuvant or palliative chemotherapy on the basis of 5-fluorouracil, it is advisable to check for possible cardiotoxicity and simultaneously to monitor thyroid gland functions. This systematic monitoring may improve the quality of life in cancer patients.
- 000
- 00000naa 2200000 a 4500
- 001
- bmc10000919
- 003
- CZ-PrNML
- 005
- 20111210154823.0
- 008
- 100115s2007 gr e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gr
- 100 1_
- $a Holubec, Luboš, $d 1972- $7 xx0068645
- 245 10
- $a Dynamic monitoring of cardio-specific markers and markers of thyroid gland function in cancer patients--a pilot study / $c Holubec L Jr, Topolcan O, Finek J, Salvet J, Svoboda T, Svobodova S, Mrazkova P, Ludvikova M
- 314 __
- $a Departments of Oncology, University Hospital and Medical Faculty Pilsen, Charles University Prague, Czech Republic. holubec@fnplzen.cz
- 520 9_
- $a BACKGROUND: With the increased effectiveness of anticancer therapy, much more attention is being paid to the monitoring of the side-effects of chemotherapy, which often constitute a limiting factor in anticancer therapy. In this pilot study, the results of our monitoring of changes in cardio-specific markers and thyroid gland parameters in patients with colorectal carcinoma in the course of adjuvant and palliative chemotherapy are presented. PATIENTS AND METHODS: A total of 42 patients with colorectal carcinoma were monitored (median age 52 years, range 34-82 years); in these patients a post-operative adjuvant or palliative chemotherapy was applied (de Gramont's or FOLFIRI regimen). In all of these patients, the cardio-specific markers brain natriuretic peptide (BNP) and troponin I were assessed, as well as markers of thyroid gland function, TSH and FT4. RESULTS: In the course of chemotherapy, more than half of the patients showed laboratory signs of coronary ischemia; in 6 of these (14%) coronary ischemia was manifested with troponin I levels above 0.3 microg/L. Twenty patients (48%) had laboratory signs of heart failure in the course of adjuvant or palliative chemotherapy. A more frequent incidence of elevated cardio-specific enzymes was observed in continual regimens than in bolus application of fluorouracil. Reduced TSH values were observed in the course of chemotherapy in 9 patients (21%), without changes in FT4 values. An increase in TSH values was observed in 4 patients (10%), again without changes in FT4 values. CONCLUSION: The pilot study demonstrated that in patients undergoing treatment for colorectal carcinoma by adjuvant or palliative chemotherapy on the basis of 5-fluorouracil, it is advisable to check for possible cardiotoxicity and simultaneously to monitor thyroid gland functions. This systematic monitoring may improve the quality of life in cancer patients.
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a protokoly antitumorózní kombinované chemoterapie $x škodlivé účinky $7 D000971
- 650 _2
- $a adjuvantní chemoterapie $x škodlivé účinky $7 D017024
- 650 _2
- $a kolorektální nádory $x farmakoterapie $7 D015179
- 650 _2
- $a fluorouracil $x aplikace a dávkování $x škodlivé účinky $7 D005472
- 650 _2
- $a srdce $x účinky léků $7 D006321
- 650 _2
- $a srdeční selhání $x chemicky indukované $7 D006333
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a ischemická choroba srdeční $x chemicky indukované $7 D017202
- 650 _2
- $a natriuretický peptid typu B $x účinky léků $7 D020097
- 650 _2
- $a paliativní péče $7 D010166
- 650 _2
- $a pilotní projekty $7 D010865
- 650 _2
- $a štítná žláza $x účinky léků $7 D013961
- 650 _2
- $a thyreotropin $x účinky léků $7 D013972
- 650 _2
- $a thyroxin $x účinky léků $7 D013974
- 650 _2
- $a troponin I $x škodlivé účinky $7 D019210
- 700 1_
- $a Topolčan, Ondřej, $d 1943- $7 jn20000402383
- 700 1_
- $a Fínek, Jindřich, $d 1957- $7 xx0026897
- 700 1_
- $a Salvét, Jiří $7 xx0129316
- 700 1_
- $a Svoboda, Tomáš, $d 1968 červenec 12.- $7 xx0137055
- 700 1_
- $a Svobodová, Šárka $7 xx0104598
- 700 1_
- $a Mrázková, Petra, $d 1969- $7 skuk0000937
- 700 1_
- $a Ludvíková, Marie, $d 1956- $7 xx0073926
- 773 0_
- $w MED00000478 $t Anticancer research $g Roč. 27, č. 4A (2007), s. 1883-1886 $x 0250-7005
- 910 __
- $a ABA008 $b x $y 8
- 990 __
- $a 20100114083259 $b ABA008
- 991 __
- $a 20100211151956 $b ABA008
- 999 __
- $a ok $b bmc $g 703647 $s 566088
- BAS __
- $a 3
- BMC __
- $a 2007 $b 27 $c 4A $d 1883-1886 $i 0250-7005 $m Anticancer research $x MED00000478
- LZP __
- $a 2010-b1/vtme