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Adenosine A(3) receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis
M. Hofer, M. Pospisil, V. Znojil, J. Hola, A. Vacek, D. Streitova
Jazyk angličtina Země Francie
- MeSH
- adenosin analogy a deriváty farmakologie MeSH
- agonisté adenosinového receptoru A3 MeSH
- buněčný rodokmen MeSH
- buňky kostní dřeně účinky léků MeSH
- erytroidní buňky účinky léků MeSH
- financování organizované MeSH
- granulocyty účinky léků MeSH
- hematopoéza účinky léků MeSH
- homeostáza účinky léků MeSH
- inbrední kmeny myší MeSH
- kostní dřeň fyziologie MeSH
- myši MeSH
- proliferace buněk účinky léků MeSH
- receptor adenosinový A3 MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
The present study was performed to define the optimum conditions of the stimulatory action of the adenosine A(3) receptor agonist, N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), on bone marrow hematopoiesis in mice. Effects of 2-day treatment with IB-MECA given at single doses of 200nmol/kg twice daily were investigated in normal mice and in mice whose femoral bone marrow cells were either depleted or regenerating after pretreatment with the cytotoxic drug 5-fluorouracil. Morphological criteria were used to determine the proliferation state of the granulocytic and erythroid cell systems. Significant negative correlation between the control proliferation state and the increase of cell proliferation after IB-MECA treatment irrespective of the cell lineage investigated was found. The results suggest the homeostatic character of the induced stimulatory effects and the need to respect the functional state of the target tissue when investigating effects of adenosine receptor agonists under in vivo conditions.
Citace poskytuje Crossref.org
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- $a The present study was performed to define the optimum conditions of the stimulatory action of the adenosine A(3) receptor agonist, N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), on bone marrow hematopoiesis in mice. Effects of 2-day treatment with IB-MECA given at single doses of 200nmol/kg twice daily were investigated in normal mice and in mice whose femoral bone marrow cells were either depleted or regenerating after pretreatment with the cytotoxic drug 5-fluorouracil. Morphological criteria were used to determine the proliferation state of the granulocytic and erythroid cell systems. Significant negative correlation between the control proliferation state and the increase of cell proliferation after IB-MECA treatment irrespective of the cell lineage investigated was found. The results suggest the homeostatic character of the induced stimulatory effects and the need to respect the functional state of the target tissue when investigating effects of adenosine receptor agonists under in vivo conditions.
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