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Serum alpha-tocopherol, retinol and neopterin during paclitaxel/carboplatin chemotherapy

Bohuslav Melichar, Hana Kalábová, Lenka Krčmová, Lubor Urbánek, Radomír Hyšpler, Eva Malířová, Dagmar Solichová

. 2007 ; 27 (6C) : 4397-4401.

Language English Country Greece

Persistent link   https://www.medvik.cz/link/bmc10026706

Grant support
NR8156 MZ0 CEP Register
NR9096 MZ0 CEP Register

BACKGROUND: Disorders of antioxidant balance are considered to be involved in the toxicity associated with radiotherapy or chemotherapy. PATIENTS AND METHODS: Serum alpha-tocopherol and retinol were determined, by high performance liquid chromatography, before and during therapy with a combination of paclitaxel and carboplatin in 28 patients with breast and ovarian cancer. Serum neopterin and cholesterol were measured using a radioimmunoassay and enzymatic colorimetric method, respectively. RESULTS: Compared to pretreatment concentrations, a significant increase was observed in serum alpha-tocopherol and retinol concentrations during therapy that was associated with decreased serum neopterin concentrations. Serum alpha-tocopherol concentrations were significantly higher during therapy in patients who did not experience serious toxicity. CONCLUSION: An increase in alpha-tocopherol and retinol during therapy with combination paclitaxel/carboplatin may be explained by inhibition of systemic immune activation secondary to control of the tumor with effective chemotherapy. Lower alpha-tocopherol concentrations were associated with the toxicity of therapy.

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$a Melichar, Bohuslav, $d 1965- $7 skuk0000853 $u Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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$a Serum alpha-tocopherol, retinol and neopterin during paclitaxel/carboplatin chemotherapy / $c Bohuslav Melichar, Hana Kalábová, Lenka Krčmová, Lubor Urbánek, Radomír Hyšpler, Eva Malířová, Dagmar Solichová
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$a Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, 500 05 Hradec Kralove, Czech Republic. melichar@fnhk.cz
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$a BACKGROUND: Disorders of antioxidant balance are considered to be involved in the toxicity associated with radiotherapy or chemotherapy. PATIENTS AND METHODS: Serum alpha-tocopherol and retinol were determined, by high performance liquid chromatography, before and during therapy with a combination of paclitaxel and carboplatin in 28 patients with breast and ovarian cancer. Serum neopterin and cholesterol were measured using a radioimmunoassay and enzymatic colorimetric method, respectively. RESULTS: Compared to pretreatment concentrations, a significant increase was observed in serum alpha-tocopherol and retinol concentrations during therapy that was associated with decreased serum neopterin concentrations. Serum alpha-tocopherol concentrations were significantly higher during therapy in patients who did not experience serious toxicity. CONCLUSION: An increase in alpha-tocopherol and retinol during therapy with combination paclitaxel/carboplatin may be explained by inhibition of systemic immune activation secondary to control of the tumor with effective chemotherapy. Lower alpha-tocopherol concentrations were associated with the toxicity of therapy.
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$a Kalábová, Hana. $7 xx0240731 $u Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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$a Krčmová Kujovská, Lenka, $7 xx0209338 $u Department of Gerontology and Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic $d 1981-
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$a Malířová, Eva $7 xx0158967 $u Department of Nuclear Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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$a Solichová, Dagmar $7 xx0060526 $u Department of Gerontology and Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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