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Atrophie multi-systematisee et maladie d'Alzheimer: association rare de deux affections neuro-degeneratives. A propos d'un cas
R Rusina, F Bourdain, R Matej
Jazyk francouzština Země Francie
Typ dokumentu kazuistiky
- MeSH
- Alzheimerova nemoc komplikace patologie MeSH
- amyloidní plaky patologie MeSH
- fatální výsledek MeSH
- imunohistochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mozeček patologie MeSH
- mozek patologie MeSH
- mozková kůra patologie MeSH
- multisystémová atrofie komplikace patologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Multiple system atrophy (MSA) is a neurodegenerative disorder typically characterised by cerebellar dysfunction, parkinsonism, pyramidal signs and dysautonomy. Cognitive impairement is usually limited to a moderate subcortical dysexecutive syndrom. We report the case of a 62-year-old woman suffering from MSA who progressively developed severe dementia. Neuropathological examination confirmed the diagnosis of definite MSA and also showed histopathological hallmarks of Alzheimer's disease. This association is extremely rare in the literature. Our observation confirmes that franc dementia in MSA should prompt a search for another associated cause and underlines the usefulness of neuropathological verifications in atypical clinical pictures.
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- $a Rusina, Robert, $d 1969- $7 mzk2007386024
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- 314 __
- $a Service de Neurologie, Hopital Thomayer, Prague, Republique tcheque. robert.rusina@ftn.cz
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- $a Multiple system atrophy (MSA) is a neurodegenerative disorder typically characterised by cerebellar dysfunction, parkinsonism, pyramidal signs and dysautonomy. Cognitive impairement is usually limited to a moderate subcortical dysexecutive syndrom. We report the case of a 62-year-old woman suffering from MSA who progressively developed severe dementia. Neuropathological examination confirmed the diagnosis of definite MSA and also showed histopathological hallmarks of Alzheimer's disease. This association is extremely rare in the literature. Our observation confirmes that franc dementia in MSA should prompt a search for another associated cause and underlines the usefulness of neuropathological verifications in atypical clinical pictures.
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- $a Bourdain, F.
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- $a Matěj, Radoslav, $d 1974- $7 xx0103860
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