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Tooth agenesis: from molecular genetics to molecular dentistry
E Matalova, J Fleischmannova, PT Sharpe, AS Tucker
Jazyk angličtina Země Spojené státy americké
Typ dokumentu přehledy
NLK
ProQuest Central
od 1996-02-01 do 2010-10-31
SAGE Publications Journals
od 1999-01-01 do 2015-12-31
Nursing & Allied Health Database (ProQuest)
od 1996-02-01 do 2010-10-31
Health & Medicine (ProQuest)
od 1996-02-01 do 2010-10-31
- MeSH
- abnormality úst genetika komplikace MeSH
- anodoncie genetika komplikace terapie MeSH
- financování organizované MeSH
- lidé MeSH
- odontogeneze genetika MeSH
- předpověď MeSH
- syndrom MeSH
- tkáňové inženýrství trendy MeSH
- zubní lékařství trendy MeSH
- zubní zárodek fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
Tooth agenesis may originate from either genetic or environmental factors. Genetically determined hypodontic disorders appear as isolated features or as part of a syndrome. Msx1, Pax9, and Axin2 are involved in non-syndromic hypodontia, while genes such as Shh, Pitx2, Irf6, and p63 are considered to participate in syndromic genetic disorders, which include tooth agenesis. In dentistry, artificial tooth implants represent a common solution to tooth loss problems; however, molecular dentistry offers promising solutions for the future. In this paper, the genetic and molecular bases of non-syndromic and syndromic hypodontia are reviewed, and the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis are discussed.
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- $a Tooth agenesis may originate from either genetic or environmental factors. Genetically determined hypodontic disorders appear as isolated features or as part of a syndrome. Msx1, Pax9, and Axin2 are involved in non-syndromic hypodontia, while genes such as Shh, Pitx2, Irf6, and p63 are considered to participate in syndromic genetic disorders, which include tooth agenesis. In dentistry, artificial tooth implants represent a common solution to tooth loss problems; however, molecular dentistry offers promising solutions for the future. In this paper, the genetic and molecular bases of non-syndromic and syndromic hypodontia are reviewed, and the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis are discussed.
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