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Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea
B. Melichar, J. Dvořák, L. Krčmová, R. Hyšpler, L. Urbánek, D. Solichová
Jazyk angličtina Země Spojené státy americké
Typ dokumentu práce podpořená grantem, srovnávací studie
- MeSH
- dospělí MeSH
- gastrointestinální stromální tumory farmakoterapie komplikace patologie MeSH
- intestinální absorpce MeSH
- laktulosa moč MeSH
- lidé středního věku MeSH
- lidé MeSH
- mannitol moč MeSH
- mladý dospělý MeSH
- nádory rekta farmakoterapie komplikace patologie MeSH
- permeabilita MeSH
- prognóza MeSH
- protokoly protinádorové kombinované chemoterapie škodlivé účinky MeSH
- průjem farmakoterapie chemicky indukované metabolismus MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- vitamin A metabolismus MeSH
- xylosa moč MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
- srovnávací studie MeSH
OBJECTIVE: Gastrointestinal toxicity is one of the most common side effects of anticancer therapy. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea (CID). METHODS: We have assessed intestinal permeability, by measuring absorption of lactulose, mannitol, xylose, and vitamin A absorption, in 11 patients with CID, 10 healthy controls, and 24 untreated patients with gastrointestinal tumors. Urinary lactulose, mannitol and xylose were measured by capillary gas chromatography and serum retinol and retinyl esters were determined by high performance liquid chromatography. The results obtained in patients and controls were compared by Mann-Whitney U test. RESULTS: Lactulose/mannitol and lactulose/xylose ratios were increased and retinol esters (retinyl palmitate and retinyl stearate) were decreased significantly in patients with CID. CONCLUSIONS: Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID.
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- 20161227113057.0
- 008
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- 009
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- 040 __
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- $a eng
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- $a Melichar, Bohuslav, $d 1965- $7 skuk0000853
- 245 10
- $a Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea / $c B. Melichar, J. Dvořák, L. Krčmová, R. Hyšpler, L. Urbánek, D. Solichová
- 314 __
- $a Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Kralove, Czech Republic. bohuslav.melichar@fnol.cz
- 520 9_
- $a OBJECTIVE: Gastrointestinal toxicity is one of the most common side effects of anticancer therapy. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea (CID). METHODS: We have assessed intestinal permeability, by measuring absorption of lactulose, mannitol, xylose, and vitamin A absorption, in 11 patients with CID, 10 healthy controls, and 24 untreated patients with gastrointestinal tumors. Urinary lactulose, mannitol and xylose were measured by capillary gas chromatography and serum retinol and retinyl esters were determined by high performance liquid chromatography. The results obtained in patients and controls were compared by Mann-Whitney U test. RESULTS: Lactulose/mannitol and lactulose/xylose ratios were increased and retinol esters (retinyl palmitate and retinyl stearate) were decreased significantly in patients with CID. CONCLUSIONS: Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID.
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- $a senioři nad 80 let $7 D000369
- 650 _2
- $a protokoly protinádorové kombinované chemoterapie $x škodlivé účinky $7 D000971
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- $a Krčmová Kujovská, Lenka, $7 xx0209338 $d 1981-
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- $a Hyšpler, Radomír, $d 1972- $7 nlk20040155091
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- $t American Journal of Clinical Oncology $g Roč. 31, č. 6 (2008), s. 580-584 $w MED00000238
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