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Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum
P. Matějková, M. Flasarová, H. Zákoucká, M. Bořek, S. Křemenová, P. Arenberger, V. Woznicová, G.M. Weinstock, D. Šmajs
Journal of Medical Microbiology.
2009 ;
58 (Pt 6) :
832-836.
Language English Country Great Britain
Document type Case Reports
Persistent link
https://www.medvik.cz/link/bmc11009382
Online
NLK
Free Medical Journals
from 1968 to 1 year ago
- MeSH
- Anti-Bacterial Agents pharmacology therapeutic use MeSH
- Drug Resistance, Bacterial genetics MeSH
- Child MeSH
- DNA, Bacterial analysis isolation & purification MeSH
- Adult MeSH
- Financing, Organized MeSH
- Infant MeSH
- Rabbits MeSH
- Middle Aged MeSH
- Humans MeSH
- Macrolides pharmacology therapeutic use MeSH
- Adolescent MeSH
- Young Adult MeSH
- Mutation MeSH
- Treatment Failure MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- RNA, Ribosomal, 23S genetics MeSH
- Sequence Analysis, DNA MeSH
- Spiramycin pharmacology therapeutic use MeSH
- Syphilis epidemiology drug therapy microbiology MeSH
- Treponema pallidum genetics drug effects MeSH
- Animals MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Rabbits MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Animals MeSH
- Publication type
- Case Reports MeSH
- Geographicals
- Czech Republic MeSH
We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic. The prevalence of A2058G and A2059G mutations among clinical specimens was 18.2 and 18.2 %, respectively.
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- $a We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic. The prevalence of A2058G and A2059G mutations among clinical specimens was 18.2 and 18.2 %, respectively.
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