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Improved detection of pancreatic islets in vivo using double contrast

V. Herynek, Z. Berková, E. Dovolilová, D. Jirák, J. Kříž, P. Girman, F. Saudek, M. Hájek

. 2011 ; 6 (4) : 308-313.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12022196

The transplantation of pancreatic islets containing β-cells, which produce insulin, is an alternative approach to the treatment of type 1 diabetes mellitus. The non-invasive visualization of transplanted islets can be performed using MRI; however, this requires labeling of the islets with a suitable contrast agent prior to transplantation. The detection of islets labeled by iron oxide-based contrast agents and transplanted into the liver tissue can be significantly improved using the intravenous administration of a suitable gadolinium contrast agent prior to MRI. The applied contrast agent not only improves the contrast-to-noise ratio, but also eliminates artifacts that may lead to an overestimation of the number of hypointense spots and their area; thus it improves the accuracy of automated and semi-automated procedures used for transplanted islet segmentation and quantification.

Citace poskytuje Crossref.org

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