-
Something wrong with this record ?
Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation
M. Rabišková, T. Bautzová, J. Gajdziok, K. Dvořáčková, A. Lamprecht, Y. Pellequer, J. Spilková,
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Alginates chemistry MeSH
- Anti-Inflammatory Agents administration & dosage chemistry pharmacology MeSH
- Administration, Oral MeSH
- Time Factors MeSH
- Chemistry, Pharmaceutical MeSH
- Chitosan chemistry MeSH
- Technology, Pharmaceutical methods MeSH
- Gastrointestinal Agents administration & dosage chemistry pharmacology MeSH
- Colitis chemically induced drug therapy pathology MeSH
- Colon drug effects pathology MeSH
- Hydrogen-Ion Concentration MeSH
- Rats MeSH
- Glucuronic Acid chemistry MeSH
- Trinitrobenzenesulfonic Acid MeSH
- Hexuronic Acids chemistry MeSH
- Caffeic Acids chemistry MeSH
- Drug Implants MeSH
- Methylcellulose analogs & derivatives chemistry MeSH
- Disease Models, Animal MeSH
- Zinc Acetate chemistry MeSH
- Rats, Wistar MeSH
- Drug Compounding MeSH
- Buffers MeSH
- Solubility MeSH
- Rutin administration & dosage chemistry pharmacology MeSH
- Drug Stability MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Preparation of coated pellets intended for rutin colon delivery, their evaluation in vitro and in vivo in experimental colitis in rats was the purpose of this study. Pellets were obtained using extrusion/spheronization and coated with three types of coatings (caffeic acid/hypromellose/alginic acid; sodium alginate/hypromellose/zinc acetate; sodium alginate/chitosan). Dissolution using buffers of pH values, β-glucosidase and times corresponding to gastrointestinal tract (GIT) was provided. Pellets coated with alginate/chitosan showed low rutin dissolution (12-14%) in upper GIT conditions and fast release (87-89%) under colon conditions; that is a good presumption of intended rutin release. After colitis induction and development, the rats were treated with pellets and rutin solution administered orally, solution also rectally. Colon/body weight ratio, myeloperoxidase activity and histological evaluation were performed. Rutin was able to promote colonic healing at the dose of 10mg/kg: colon/body weight ratio decreased and myeloperoxidase activity was significantly suppressed. Pellets coated with alginate/chitosan applied orally and rutin solution administered rectally showed the best efficacy. The combination of rutin as natural product, mucoadhesive chitosan degraded in the colon and sodium alginate as the main coating substance in the form of pellets create a promising preparation for therapy of this severe illness.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12024285
- 003
- CZ-PrNML
- 005
- 20121207110453.0
- 007
- ta
- 008
- 120815s2012 ne f 000 0#eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ijpharm.2011.10.045 $2 doi
- 035 __
- $a (PubMed)22079717
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Rabišková, Miloslava $u Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, 612 42 Brno, Czech Republic. rabiskovam@vfu.cz
- 245 10
- $a Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation / $c M. Rabišková, T. Bautzová, J. Gajdziok, K. Dvořáčková, A. Lamprecht, Y. Pellequer, J. Spilková,
- 520 9_
- $a Preparation of coated pellets intended for rutin colon delivery, their evaluation in vitro and in vivo in experimental colitis in rats was the purpose of this study. Pellets were obtained using extrusion/spheronization and coated with three types of coatings (caffeic acid/hypromellose/alginic acid; sodium alginate/hypromellose/zinc acetate; sodium alginate/chitosan). Dissolution using buffers of pH values, β-glucosidase and times corresponding to gastrointestinal tract (GIT) was provided. Pellets coated with alginate/chitosan showed low rutin dissolution (12-14%) in upper GIT conditions and fast release (87-89%) under colon conditions; that is a good presumption of intended rutin release. After colitis induction and development, the rats were treated with pellets and rutin solution administered orally, solution also rectally. Colon/body weight ratio, myeloperoxidase activity and histological evaluation were performed. Rutin was able to promote colonic healing at the dose of 10mg/kg: colon/body weight ratio decreased and myeloperoxidase activity was significantly suppressed. Pellets coated with alginate/chitosan applied orally and rutin solution administered rectally showed the best efficacy. The combination of rutin as natural product, mucoadhesive chitosan degraded in the colon and sodium alginate as the main coating substance in the form of pellets create a promising preparation for therapy of this severe illness.
- 650 _2
- $a aplikace orální $7 D000284
- 650 _2
- $a algináty $x chemie $7 D000464
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a antiflogistika $x aplikace a dávkování $x chemie $x farmakologie $7 D000893
- 650 _2
- $a pufry $7 D002021
- 650 _2
- $a kyseliny kávové $x chemie $7 D002109
- 650 _2
- $a chemie farmaceutická $7 D002626
- 650 _2
- $a chitosan $x chemie $7 D048271
- 650 _2
- $a kolitida $x chemicky indukované $x farmakoterapie $x patologie $7 D003092
- 650 _2
- $a kolon $x účinky léků $x patologie $7 D003106
- 650 _2
- $a modely nemocí na zvířatech $7 D004195
- 650 _2
- $a příprava léků $7 D004339
- 650 _2
- $a léky implantované $7 D004343
- 650 _2
- $a stabilita léku $7 D004355
- 650 _2
- $a gastrointestinální látky $x aplikace a dávkování $x chemie $x farmakologie $7 D005765
- 650 _2
- $a kyselina glukuronová $x chemie $7 D020723
- 650 _2
- $a kyseliny hexuronové $x chemie $7 D006603
- 650 _2
- $a koncentrace vodíkových iontů $7 D006863
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a methylcelulosa $x analogy a deriváty $x chemie $7 D008747
- 650 _2
- $a krysa rodu Rattus $7 D051381
- 650 _2
- $a potkani Wistar $7 D017208
- 650 _2
- $a rutin $x aplikace a dávkování $x chemie $x farmakologie $7 D012431
- 650 _2
- $a rozpustnost $7 D012995
- 650 _2
- $a farmaceutická technologie $x metody $7 D013678
- 650 _2
- $a časové faktory $7 D013997
- 650 _2
- $a kyselina trinitrobenzensulfonová $7 D014302
- 650 _2
- $a octan zinečnatý $x chemie $7 D019345
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Bautzová, Tereza
- 700 1_
- $a Gajdziok, Jan
- 700 1_
- $a Dvořáčková, Kateřina
- 700 1_
- $a Lamprecht, Alf
- 700 1_
- $a Pellequer, Yann
- 700 1_
- $a Spilková, Jiřina
- 773 0_
- $w MED00002359 $t International journal of pharmaceutics $x 1873-3476 $g Roč. 422, č. 1-2 (2012), s. 151-9
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/22079717 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m
- 990 __
- $a 20120815 $b ABA008
- 991 __
- $a 20121207110527 $b ABA008
- 999 __
- $a ok $b bmc $g 946433 $s 781613
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2012 $b 422 $c 1-2 $d 151-9 $i 1873-3476 $m International journal of pharmaceutics $n Int. j. pharm. $x MED00002359
- LZP __
- $a Pubmed-20120815/12/02
