• Je něco špatně v tomto záznamu ?

Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention

M. Vlasin, M. Dvorak, M. Dvorakova, P. Rauser, L. Lexmaulova, Z. Gregor,

. 2010 ; 126 (1) : 56-60. [pub] 20100410

Jazyk angličtina Země Spojené státy americké

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc12025794

INTRODUCTION: The aim of the study was to evaluate and compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). MATERIALS AND METHODS: We modified a previously published rabbit model of arterial thrombosis prevention [1,2] to compare unfractionated heparin and two different doses of two low-molecular weight heparin fragments--nadroparin and enoxaparin. Thrombosis in the distal aorta was triggered by vessel wall injury and critical stenosis. Blood flow in the damaged arterial segment was monitored by a flow probe placed distal to the constrictor. The primary endpoints of the study were: (1) cumulative flow, (2) time to occlusion and (3) residual clot weight. Thirty six animals were split into 6 groups with six animals in each group. Control groups were given saline or heparin and four more groups were used to compare LMWH's at 2 different doses. RESULTS: In our study, all treatments were superior to the saline control group (alpha

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12025794
003      
CZ-PrNML
005      
20121210101150.0
007      
ta
008      
120817e20100410xxu f 000 0#eng||
009      
AR
024    7_
$a 10.1016/j.thromres.2010.03.001 $2 doi
035    __
$a (PubMed)20382412
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Vlasin, Michal $u University of Veterinary and Pharmaceutical Sciences Brno, and st. Ann's Faculty Hosital Brno, Czech Republic. vlasinm@vfu.cz
245    10
$a Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention / $c M. Vlasin, M. Dvorak, M. Dvorakova, P. Rauser, L. Lexmaulova, Z. Gregor,
520    9_
$a INTRODUCTION: The aim of the study was to evaluate and compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). MATERIALS AND METHODS: We modified a previously published rabbit model of arterial thrombosis prevention [1,2] to compare unfractionated heparin and two different doses of two low-molecular weight heparin fragments--nadroparin and enoxaparin. Thrombosis in the distal aorta was triggered by vessel wall injury and critical stenosis. Blood flow in the damaged arterial segment was monitored by a flow probe placed distal to the constrictor. The primary endpoints of the study were: (1) cumulative flow, (2) time to occlusion and (3) residual clot weight. Thirty six animals were split into 6 groups with six animals in each group. Control groups were given saline or heparin and four more groups were used to compare LMWH's at 2 different doses. RESULTS: In our study, all treatments were superior to the saline control group (alpha<or=0,01). Standard heparin was inferior (alpha<or=0,05) to both low molecular weight heparins for all primary endpoints (cumulative flow, time to occlusion and residual clot weight). There were no differences between the LMWH's except for cumulative flow at high doses. CONCLUSIONS: This study revealed no relevant differences between nadroparin and enoxaparin for the primary endpoints of our model. Clinical use of each drug remains a personal preference.
650    _2
$a zvířata $7 D000818
650    _2
$a arterie $7 D001158
650    _2
$a klinické zkoušky jako téma $7 D002986
650    _2
$a enoxaparin $x terapeutické užití $7 D017984
650    _2
$a heparin $x terapeutické užití $7 D006493
650    _2
$a heparin nízkomolekulární $x terapeutické užití $7 D006495
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a nadroparin $x terapeutické užití $7 D017762
650    _2
$a králíci $7 D011817
650    _2
$a trombóza $x farmakoterapie $x prevence a kontrola $7 D013927
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Dvorak, Martin
700    1_
$a Dvorakova, Martina
700    1_
$a Rauser, Petr
700    1_
$a Lexmaulova, Leona
700    1_
$a Gregor, Zdenek
773    0_
$w MED00004518 $t Thrombosis research $x 1879-2472 $g Roč. 126, č. 1 (20100410), s. 56-60
856    41
$u https://pubmed.ncbi.nlm.nih.gov/20382412 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m
990    __
$a 20120817 $b ABA008
991    __
$a 20121210101227 $b ABA008
999    __
$a ok $b bmc $g 947836 $s 783140
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 126 $c 1 $d 56-60 $e 20100410 $i 1879-2472 $m Thrombosis research $n Thromb Res $x MED00004518
LZP    __
$a Pubmed-20120817/10/03

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...