-
Something wrong with this record ?
Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention
M. Vlasin, M. Dvorak, M. Dvorakova, P. Rauser, L. Lexmaulova, Z. Gregor,
Language English Country United States
Document type Comparative Study, Journal Article
- MeSH
- Arteries MeSH
- Enoxaparin therapeutic use MeSH
- Heparin, Low-Molecular-Weight therapeutic use MeSH
- Heparin therapeutic use MeSH
- Clinical Trials as Topic MeSH
- Rabbits MeSH
- Nadroparin therapeutic use MeSH
- Thrombosis drug therapy prevention & control MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
INTRODUCTION: The aim of the study was to evaluate and compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). MATERIALS AND METHODS: We modified a previously published rabbit model of arterial thrombosis prevention [1,2] to compare unfractionated heparin and two different doses of two low-molecular weight heparin fragments--nadroparin and enoxaparin. Thrombosis in the distal aorta was triggered by vessel wall injury and critical stenosis. Blood flow in the damaged arterial segment was monitored by a flow probe placed distal to the constrictor. The primary endpoints of the study were: (1) cumulative flow, (2) time to occlusion and (3) residual clot weight. Thirty six animals were split into 6 groups with six animals in each group. Control groups were given saline or heparin and four more groups were used to compare LMWH's at 2 different doses. RESULTS: In our study, all treatments were superior to the saline control group (alpha
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12025794
- 003
- CZ-PrNML
- 005
- 20121210101150.0
- 007
- ta
- 008
- 120817e20100410xxu f 000 0#eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.thromres.2010.03.001 $2 doi
- 035 __
- $a (PubMed)20382412
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Vlasin, Michal $u University of Veterinary and Pharmaceutical Sciences Brno, and st. Ann's Faculty Hosital Brno, Czech Republic. vlasinm@vfu.cz
- 245 10
- $a Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention / $c M. Vlasin, M. Dvorak, M. Dvorakova, P. Rauser, L. Lexmaulova, Z. Gregor,
- 520 9_
- $a INTRODUCTION: The aim of the study was to evaluate and compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). MATERIALS AND METHODS: We modified a previously published rabbit model of arterial thrombosis prevention [1,2] to compare unfractionated heparin and two different doses of two low-molecular weight heparin fragments--nadroparin and enoxaparin. Thrombosis in the distal aorta was triggered by vessel wall injury and critical stenosis. Blood flow in the damaged arterial segment was monitored by a flow probe placed distal to the constrictor. The primary endpoints of the study were: (1) cumulative flow, (2) time to occlusion and (3) residual clot weight. Thirty six animals were split into 6 groups with six animals in each group. Control groups were given saline or heparin and four more groups were used to compare LMWH's at 2 different doses. RESULTS: In our study, all treatments were superior to the saline control group (alpha<or=0,01). Standard heparin was inferior (alpha<or=0,05) to both low molecular weight heparins for all primary endpoints (cumulative flow, time to occlusion and residual clot weight). There were no differences between the LMWH's except for cumulative flow at high doses. CONCLUSIONS: This study revealed no relevant differences between nadroparin and enoxaparin for the primary endpoints of our model. Clinical use of each drug remains a personal preference.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a arterie $7 D001158
- 650 _2
- $a klinické zkoušky jako téma $7 D002986
- 650 _2
- $a enoxaparin $x terapeutické užití $7 D017984
- 650 _2
- $a heparin $x terapeutické užití $7 D006493
- 650 _2
- $a heparin nízkomolekulární $x terapeutické užití $7 D006495
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a nadroparin $x terapeutické užití $7 D017762
- 650 _2
- $a králíci $7 D011817
- 650 _2
- $a trombóza $x farmakoterapie $x prevence a kontrola $7 D013927
- 655 _2
- $a srovnávací studie $7 D003160
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Dvorak, Martin
- 700 1_
- $a Dvorakova, Martina
- 700 1_
- $a Rauser, Petr
- 700 1_
- $a Lexmaulova, Leona
- 700 1_
- $a Gregor, Zdenek
- 773 0_
- $w MED00004518 $t Thrombosis research $x 1879-2472 $g Roč. 126, č. 1 (20100410), s. 56-60
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/20382412 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m
- 990 __
- $a 20120817 $b ABA008
- 991 __
- $a 20121210101227 $b ABA008
- 999 __
- $a ok $b bmc $g 947836 $s 783140
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2010 $b 126 $c 1 $d 56-60 $e 20100410 $i 1879-2472 $m Thrombosis research $n Thromb Res $x MED00004518
- LZP __
- $a Pubmed-20120817/10/03