• Something wrong with this record ?

Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in the Czech Republic

P. Holochová, V. Růzicková, R. Pantůcek, P. Petrás, R. Janisch, J. Doskar,

. 2010 ; 161 (4) : 260-7. [pub] 20100409

Language English Country France

Document type Journal Article, Research Support, Non-U.S. Gov't

We have isolated and characterized two distinct types of exfoliative toxin A (ETA)-converting bacteriophages originating from Staphylococcus aureus strains responsible for massive outbreaks of pemphigus neonatorum in the Czech Republic. Three induced phages designated as ph iB531, phi B557 and phi B122 were found to be capable of transferring the eta gene into the prophageless non-toxigenic S. aureus strain and converting it into an ETA producer. Comparisons of the phage sequences derived from 12 selected genes and 2 genomic segments (polymorphic P2 and conserved C4) revealed that phi B531 and phi B557 were identical each other, but phi B122 differed from them in 5 gene sequences, the xis gene content and the virion protein profile. Thus, phi B122 represents a new type of still undescribed ETA-converting phage. This study highlights not only the conclusive genomic diversity of eta gene-positive phages, but also their virulence implications in impetigo S. aureus strains.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12025796
003      
CZ-PrNML
005      
20121210112031.0
007      
ta
008      
120817e20100409fr f 000 0#eng||
009      
AR
024    7_
$a 10.1016/j.resmic.2010.03.008 $2 doi
035    __
$a (PubMed)20382218
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a fr
100    1_
$a Holochová, Pavla $u Department of Genetics and Molecular Biology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlárská 2, 611 37 Brno, Czech Republic. pavlah@sci.muni.cz
245    10
$a Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in the Czech Republic / $c P. Holochová, V. Růzicková, R. Pantůcek, P. Petrás, R. Janisch, J. Doskar,
520    9_
$a We have isolated and characterized two distinct types of exfoliative toxin A (ETA)-converting bacteriophages originating from Staphylococcus aureus strains responsible for massive outbreaks of pemphigus neonatorum in the Czech Republic. Three induced phages designated as ph iB531, phi B557 and phi B122 were found to be capable of transferring the eta gene into the prophageless non-toxigenic S. aureus strain and converting it into an ETA producer. Comparisons of the phage sequences derived from 12 selected genes and 2 genomic segments (polymorphic P2 and conserved C4) revealed that phi B531 and phi B557 were identical each other, but phi B122 differed from them in 5 gene sequences, the xis gene content and the virion protein profile. Thus, phi B122 represents a new type of still undescribed ETA-converting phage. This study highlights not only the conclusive genomic diversity of eta gene-positive phages, but also their virulence implications in impetigo S. aureus strains.
650    _2
$a epidemický výskyt choroby $7 D004196
650    _2
$a exfoliatiny $x genetika $x metabolismus $7 D005083
650    _2
$a přenos genů horizontální $7 D022761
650    _2
$a genetická variace $7 D014644
650    _2
$a lidé $7 D006801
650    _2
$a molekulární sekvence - údaje $7 D008969
650    _2
$a pemfigus $x epidemiologie $x mikrobiologie $7 D010392
650    _2
$a stafylokokové infekce $x epidemiologie $x mikrobiologie $7 D013203
650    _2
$a stafylokokové bakteriofágy $x genetika $x izolace a purifikace $x metabolismus $7 D013204
650    _2
$a Staphylococcus aureus $x genetika $x metabolismus $x virologie $7 D013211
651    _2
$a Česká republika $x epidemiologie $7 D018153
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Růzicková, Vladislava
700    1_
$a Pantůcek, Roman
700    1_
$a Petrás, Petr
700    1_
$a Janisch, Roman
700    1_
$a Doskar, Jirí
773    0_
$w MED00004095 $t Research in microbiology $x 1769-7123 $g Roč. 161, č. 4 (20100409), s. 260-7
856    41
$u https://pubmed.ncbi.nlm.nih.gov/20382218 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m
990    __
$a 20120817 $b ABA008
991    __
$a 20121210112108 $b ABA008
999    __
$a ok $b bmc $g 947838 $s 783142
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 161 $c 4 $d 260-7 $e 20100409 $i 1769-7123 $m Research in microbiology $n Res Microbiol $x MED00004095
LZP    __
$a Pubmed-20120817/10/03

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...