-
Je něco špatně v tomto záznamu ?
Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in the Czech Republic
P. Holochová, V. Růzicková, R. Pantůcek, P. Petrás, R. Janisch, J. Doskar,
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- epidemický výskyt choroby MeSH
- exfoliatiny genetika metabolismus MeSH
- genetická variace MeSH
- lidé MeSH
- molekulární sekvence - údaje MeSH
- pemfigus epidemiologie mikrobiologie MeSH
- přenos genů horizontální MeSH
- stafylokokové bakteriofágy genetika izolace a purifikace metabolismus MeSH
- stafylokokové infekce epidemiologie mikrobiologie MeSH
- Staphylococcus aureus genetika metabolismus virologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
We have isolated and characterized two distinct types of exfoliative toxin A (ETA)-converting bacteriophages originating from Staphylococcus aureus strains responsible for massive outbreaks of pemphigus neonatorum in the Czech Republic. Three induced phages designated as ph iB531, phi B557 and phi B122 were found to be capable of transferring the eta gene into the prophageless non-toxigenic S. aureus strain and converting it into an ETA producer. Comparisons of the phage sequences derived from 12 selected genes and 2 genomic segments (polymorphic P2 and conserved C4) revealed that phi B531 and phi B557 were identical each other, but phi B122 differed from them in 5 gene sequences, the xis gene content and the virion protein profile. Thus, phi B122 represents a new type of still undescribed ETA-converting phage. This study highlights not only the conclusive genomic diversity of eta gene-positive phages, but also their virulence implications in impetigo S. aureus strains.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12025796
- 003
- CZ-PrNML
- 005
- 20121210112031.0
- 007
- ta
- 008
- 120817e20100409fr f 000 0#eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.resmic.2010.03.008 $2 doi
- 035 __
- $a (PubMed)20382218
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a fr
- 100 1_
- $a Holochová, Pavla $u Department of Genetics and Molecular Biology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlárská 2, 611 37 Brno, Czech Republic. pavlah@sci.muni.cz
- 245 10
- $a Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in the Czech Republic / $c P. Holochová, V. Růzicková, R. Pantůcek, P. Petrás, R. Janisch, J. Doskar,
- 520 9_
- $a We have isolated and characterized two distinct types of exfoliative toxin A (ETA)-converting bacteriophages originating from Staphylococcus aureus strains responsible for massive outbreaks of pemphigus neonatorum in the Czech Republic. Three induced phages designated as ph iB531, phi B557 and phi B122 were found to be capable of transferring the eta gene into the prophageless non-toxigenic S. aureus strain and converting it into an ETA producer. Comparisons of the phage sequences derived from 12 selected genes and 2 genomic segments (polymorphic P2 and conserved C4) revealed that phi B531 and phi B557 were identical each other, but phi B122 differed from them in 5 gene sequences, the xis gene content and the virion protein profile. Thus, phi B122 represents a new type of still undescribed ETA-converting phage. This study highlights not only the conclusive genomic diversity of eta gene-positive phages, but also their virulence implications in impetigo S. aureus strains.
- 650 _2
- $a epidemický výskyt choroby $7 D004196
- 650 _2
- $a exfoliatiny $x genetika $x metabolismus $7 D005083
- 650 _2
- $a přenos genů horizontální $7 D022761
- 650 _2
- $a genetická variace $7 D014644
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a molekulární sekvence - údaje $7 D008969
- 650 _2
- $a pemfigus $x epidemiologie $x mikrobiologie $7 D010392
- 650 _2
- $a stafylokokové infekce $x epidemiologie $x mikrobiologie $7 D013203
- 650 _2
- $a stafylokokové bakteriofágy $x genetika $x izolace a purifikace $x metabolismus $7 D013204
- 650 _2
- $a Staphylococcus aureus $x genetika $x metabolismus $x virologie $7 D013211
- 651 _2
- $a Česká republika $x epidemiologie $7 D018153
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Růzicková, Vladislava
- 700 1_
- $a Pantůcek, Roman
- 700 1_
- $a Petrás, Petr
- 700 1_
- $a Janisch, Roman
- 700 1_
- $a Doskar, Jirí
- 773 0_
- $w MED00004095 $t Research in microbiology $x 1769-7123 $g Roč. 161, č. 4 (20100409), s. 260-7
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/20382218 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m
- 990 __
- $a 20120817 $b ABA008
- 991 __
- $a 20121210112108 $b ABA008
- 999 __
- $a ok $b bmc $g 947838 $s 783142
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2010 $b 161 $c 4 $d 260-7 $e 20100409 $i 1769-7123 $m Research in microbiology $n Res Microbiol $x MED00004095
- LZP __
- $a Pubmed-20120817/10/03
