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Telomere length, molecular cytogenetic findings, and immunophenotypic features in previously untreated patients with B-chronic lymphocytic leukemia
J. Brezinova, A. Berkova, S. Vcelikova, Z. Zemanova, S. Izakova, I. Sarova, H. Cechova, J. Tajtlova, L. Grosova, L. Lizcova, E. Malinova, M. Zemanova, E. Cmunt, J. Karban, M. Trneny, J. Schwarz, K. Michalova,
Language English Country Slovakia
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NR9244
MZ0
CEP Register
- MeSH
- ADP-ribosyl Cyclase 1 analysis MeSH
- Chromosome Aberrations MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell genetics immunology metabolism MeSH
- Adult MeSH
- Immunophenotyping MeSH
- Middle Aged MeSH
- Humans MeSH
- Mutation MeSH
- ZAP-70 Protein-Tyrosine Kinase analysis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Telomere MeSH
- Immunoglobulin Heavy Chains genetics MeSH
- Immunoglobulin Variable Region genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Telomere length was evaluated by terminal repeat fragment method in 66 previously untreated patients with B-chronic lymphocytic leukemia (B-CLL) to ascertain whether telomere shortening was associated with genomic aberrations, immunoglobulin variable heavy chain (IgVH) mutational status, CD38 and ZAP-70 expression, and telomerase activity. Chromosomal aberrations were present in peripheral blood cells of 73% patients (48/66), no difference in telomere length between patients with good and intermediate prognosis according to cytogenetics was found. Association between telomere length and IgVH mutational status, ZAP-70 and CD38 expression was proved as significantly shorter telomeres in patients with unmutated IgVH status (p=0.01) and ZAP-70 positivity (p=0.01) and CD38 positivity (p=0.05) were detected. Telomerase activity was positive in 11 patients out of 21 examined, correlation between telomere length and telomerase activity was found (p=0.05). Telomere length and telomerase activity in combination with other prognostic parameters complete the risk profile of B-CLL patients and might serve for an easy decision on optimal treatment strategy. Keywords: B-chronic lymphocytic leukemia, telomere length, telomerase activity, chromosomal aberrations, prognosis.
References provided by Crossref.org
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- $a Telomere length was evaluated by terminal repeat fragment method in 66 previously untreated patients with B-chronic lymphocytic leukemia (B-CLL) to ascertain whether telomere shortening was associated with genomic aberrations, immunoglobulin variable heavy chain (IgVH) mutational status, CD38 and ZAP-70 expression, and telomerase activity. Chromosomal aberrations were present in peripheral blood cells of 73% patients (48/66), no difference in telomere length between patients with good and intermediate prognosis according to cytogenetics was found. Association between telomere length and IgVH mutational status, ZAP-70 and CD38 expression was proved as significantly shorter telomeres in patients with unmutated IgVH status (p=0.01) and ZAP-70 positivity (p=0.01) and CD38 positivity (p=0.05) were detected. Telomerase activity was positive in 11 patients out of 21 examined, correlation between telomere length and telomerase activity was found (p=0.05). Telomere length and telomerase activity in combination with other prognostic parameters complete the risk profile of B-CLL patients and might serve for an easy decision on optimal treatment strategy. Keywords: B-chronic lymphocytic leukemia, telomere length, telomerase activity, chromosomal aberrations, prognosis.
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