Telomere length, molecular cytogenetic findings, and immunophenotypic features in previously untreated patients with B-chronic lymphocytic leukemia
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- ADP-ribosyl Cyclase 1 analysis MeSH
- Chromosome Aberrations * MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell genetics immunology metabolism MeSH
- Adult MeSH
- Immunophenotyping MeSH
- Middle Aged MeSH
- Humans MeSH
- Mutation MeSH
- ZAP-70 Protein-Tyrosine Kinase analysis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Telomere * MeSH
- Immunoglobulin Heavy Chains genetics MeSH
- Immunoglobulin Variable Region genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ADP-ribosyl Cyclase 1 MeSH
- ZAP-70 Protein-Tyrosine Kinase MeSH
- Immunoglobulin Heavy Chains MeSH
- Immunoglobulin Variable Region MeSH
- ZAP70 protein, human MeSH Browser
UNLABELLED: Telomere length was evaluated by terminal repeat fragment method in 66 previously untreated patients with B-chronic lymphocytic leukemia (B-CLL) to ascertain whether telomere shortening was associated with genomic aberrations, immunoglobulin variable heavy chain (IgVH) mutational status, CD38 and ZAP-70 expression, and telomerase activity. Chromosomal aberrations were present in peripheral blood cells of 73% patients (48/66), no difference in telomere length between patients with good and intermediate prognosis according to cytogenetics was found. Association between telomere length and IgVH mutational status, ZAP-70 and CD38 expression was proved as significantly shorter telomeres in patients with unmutated IgVH status (p=0.01) and ZAP-70 positivity (p=0.01) and CD38 positivity (p=0.05) were detected. Telomerase activity was positive in 11 patients out of 21 examined, correlation between telomere length and telomerase activity was found (p=0.05). Telomere length and telomerase activity in combination with other prognostic parameters complete the risk profile of B-CLL patients and might serve for an easy decision on optimal treatment strategy. KEYWORDS: B-chronic lymphocytic leukemia, telomere length, telomerase activity, chromosomal aberrations, prognosis.
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