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Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage
R. Prymula, I. Hanovcova, M. Splino, P. Kriz, J. Motlova, V. Lebedova, P. Lommel, E. Kaliskova, T. Pascal, D. Borys, L. Schuerman
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
Nursing & Allied Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Health & Medicine (ProQuest) od 2002-01-01 do Před 2 měsíci
Family Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Health Management Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Public Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Odkazy
PubMed
21215830
DOI
10.1016/j.vaccine.2010.12.086
Knihovny.cz E-zdroje
- MeSH
- Haemophilus influenzae izolace a purifikace MeSH
- hemofilové infekce prevence a kontrola MeSH
- kojenec MeSH
- lidé MeSH
- nazofarynx mikrobiologie MeSH
- pneumokokové infekce prevence a kontrola MeSH
- pneumokokové vakcíny aplikace a dávkování imunologie MeSH
- přenašečství prevence a kontrola MeSH
- sekundární imunizace metody MeSH
- Streptococcus pneumoniae izolace a purifikace MeSH
- vakcinace metody MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Pneumococcal conjugate vaccines (PCV) may reduce nasopharyngeal carriage (NPC) of Streptococcus pneumoniae vaccine strains (VT), but serotype replacement with non-vaccine strains (NVT) has been reported. Bacterial NPC after PHiD-CV vaccination was assessed in the second year of life. Open descriptive study of NPC reported for 414 subjects vaccinated at 3-5 and 12-15 months of age with PHiD-CV with or without prophylactic paracetamol (PP) compared to 336 age-matched PCV-naïve controls. Carriage was assessed prior to and 1, 3, 7 and 12 months after PHiD-CV booster or MenACWY-TT control vaccination at 12-15 months of age. At each visit, carriage of VT was reduced by 22-35% in PHiD-CV recipients. Vaccine efficacy across all visits was 21.7% [95% CI 2.6; 37.0] (26.8% carriage in the PHiD-CV group versus 34.2% in controls). Carriage rates of NVT tended to be higher in PHiD-CV recipients. Pre-booster, these findings were more pronounced when PP had not been administered. No substantial effect of PHiD-CV vaccination was observed on NPC of other bacterial pathogens including non-typeable Haemophilus influenzae. Primary and booster vaccination with PHiD-CV reduced NPC of VT in the second year of life and tended to slightly increase that of NVT in line with previous experience with the 7-valent PCV.
Department of Epidemiology Military Medical Academy Hradec Kralove Czech Republic
Faculty of Military Health Sciences University of Defence Hradec Kralove Czech Republic
Global Vaccine Development GlaxoSmithKline Vaccines Wavre Belgium
NRL for Haemophilus Infections National Institute of Public Health Prague Czech Republic
WHO Collaborating Center for Streptococci National Institute of Public Health Prague Czech Republic
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