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Pulse wave velocity in primary hyperparathyroidism and effect of surgical therapy
J. Rosa, I. Raska, D. Wichterle, O. Petrak, B. Strauch, Z. Somloova, T. Zelinka, R. Holaj, J. Widimsky,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21107330
DOI
10.1038/hr.2010.232
Knihovny.cz E-resources
- MeSH
- Hypertension physiopathology MeSH
- Blood Glucose physiology MeSH
- Blood Pressure physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipids blood MeSH
- Fasting physiology MeSH
- Parathyroidectomy MeSH
- Hyperparathyroidism, Primary physiopathology surgery MeSH
- Pulsatile Flow physiology MeSH
- Blood Flow Velocity physiology MeSH
- Aged MeSH
- Heart Rate physiology MeSH
- Calcium blood metabolism MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The study was aimed at investigating the arterial stiffness assessed by aortic pulse wave velocity (PWV) in the presence of primary hyperparathyroidism (PH), with and without concomitant hypertension. Subsequently, we examined the effect of parathyroidectomy (PTX) on arterial stiffness. A total of 28 patients with PH and concomitant hypertension, and 16 with PH without hypertension were investigated in comparison with 28 essential hypertensive patients and 18 healthy controls, respectively. Patients were matched for age, blood pressure (BP), body mass index, lipid profile and fasting glucose. Six months after PTX, 15 patients were examined again (hypertensive as well as normotensive). PWV was obtained using the SphygmoCor applanation tonometer (AtCor Medical, West Ryde, Australia). PWV was significantly higher in patients with PH and hypertension when compared with patients with essential hypertension (10.1 vs. 8.5 ms(-1), P=0.013). PWV remained significant even after adjustment for age and BP (P=0.02). Similarly, PWV was significantly higher in PH patients without hypertension in comparison with healthy controls (7.6 vs. 5.8 ms(-1), P<0.001). Six months after surgery, in addition to a normalization of calcium metabolism, a significant decrease in systolic BP (131 vs. 123 mmHg, P=0.004) and PWV (9.1 vs. 8.5 ms(-1), P=0.024) was observed. After adjusting for BP reduction, the decrease in PWV appeared non-significant. Our data indicate that PH increases PWV as a marker of arterial stiffness, in both hypertensive and non-hypertensive patients. However, neither the calcium serum level nor the parathyroid hormone level has been associated with PWV. Specific treatment by PTX significantly decreases PWV, which may be determined primarily by improved BP control after surgery.
References provided by Crossref.org
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