• Je něco špatně v tomto záznamu ?

Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs

J. Tomankova, M. K. Rasmussen, K. Andersson, B. Ekstrand, G. Zamaratskaia

. 2012 ; 30 (24) : 3515-3518.

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12034596
E-zdroje Online Plný text

NLK ProQuest Central od 2002-01-01 do Před 2 měsíci
Nursing & Allied Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Health & Medicine (ProQuest) od 2002-01-01 do Před 2 měsíci
Family Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Health Management Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Public Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci

Odkazy

PubMed 22484351
DOI 10.1016/j.vaccine.2012.03.072
Knihovny.cz E-zdroje

In the present study, we investigated hepatic mRNA expression and activities of CYP3A and 2C in entire, surgically castrated and pigs vaccinated with Improvac. Additionally, we examined the mRNA expression of the two nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR), known to regulate CYP3A and 2C mRNA expression, respectively. Activities of CYP3A and 2C were estimated as a rate of 7-benzyloxy-4-trifluoromethylcoumarin and 7-benzyloxyquinoline metabolism (CYP3A) and tolbutamide metabolism (CYP2C). We found no effect of Improvac treatment or surgical castration on either CYP3A or 2C activities. Similarly, the mRNA expressions of CYP3A29, 2C33 and PXR were not changed. CAR mRNA expression differed only between entire and surgically castrated male pigs (p=0.005), being greater in surgically castrated pigs. Our results indicated that neither CYP3A nor 2C are affected by Improvac.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12034596
003      
CZ-PrNML
005      
20160905144024.0
007      
ta
008      
121023s2012 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.vaccine.2012.03.072 $2 doi
035    __
$a (PubMed)22484351
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Tomankova, Jana $u University of Veterinary and Pharmaceutical Science Brno, Faculty of Hygiene and Ecology, Department of Meat Hygiene and Technology, Brno, Czech Republic. tomankova.janicka@seznam.cz
245    10
$a Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs / $c J. Tomankova, M. K. Rasmussen, K. Andersson, B. Ekstrand, G. Zamaratskaia
520    9_
$a In the present study, we investigated hepatic mRNA expression and activities of CYP3A and 2C in entire, surgically castrated and pigs vaccinated with Improvac. Additionally, we examined the mRNA expression of the two nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR), known to regulate CYP3A and 2C mRNA expression, respectively. Activities of CYP3A and 2C were estimated as a rate of 7-benzyloxy-4-trifluoromethylcoumarin and 7-benzyloxyquinoline metabolism (CYP3A) and tolbutamide metabolism (CYP2C). We found no effect of Improvac treatment or surgical castration on either CYP3A or 2C activities. Similarly, the mRNA expressions of CYP3A29, 2C33 and PXR were not changed. CAR mRNA expression differed only between entire and surgically castrated male pigs (p=0.005), being greater in surgically castrated pigs. Our results indicated that neither CYP3A nor 2C are affected by Improvac.
650    _2
$a zvířata $7 D000818
650    _2
$a kastrace $x škodlivé účinky $7 D002369
650    _2
$a kumariny $x metabolismus $7 D003374
650    _2
$a cytochrom P-450 CYP3A $x biosyntéza $7 D051544
650    _2
$a systém (enzymů) cytochromů P-450 $x biosyntéza $7 D003577
650    _2
$a exprese genu $x účinky léků $7 D015870
650    _2
$a játra $x enzymologie $7 D008099
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a chinoliny $x metabolismus $7 D011804
650    _2
$a receptory cytoplazmatické a nukleární $x biosyntéza $7 D018160
650    _2
$a steroidní receptory $x biosyntéza $7 D011987
650    _2
$a prasata $7 D013552
650    _2
$a tolbutamid $x metabolismus $7 D014044
650    _2
$a antikoncepční vakcíny $x aplikace a dávkování $x škodlivé účinky $7 D022642
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Rasmussen, Martin Krøyer $u Department of Food Science, Aarhus University, Denmark. Martink.rasmussen@agrsci.dk
700    1_
$a Andersson, Kristina $u Department of Food Science, Aarhus University, Denmark $7 gn_A_00006205
700    1_
$a Ekstrand, Bo $u Department of Food Science, Aarhus University, Denmark
700    1_
$a Zamaratskaia, Galia $u Department of Food Science, BioCenter, Swedish University of Agricultural Sciences, Sweden
773    0_
$w MED00004631 $t Vaccine $x 1873-2518 $g Roč. 30, č. 24 (2012), s. 3515-3518
856    41
$u https://pubmed.ncbi.nlm.nih.gov/22484351 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20121023 $b ABA008
991    __
$a 20160905144334 $b ABA008
999    __
$a ok $b bmc $g 956606 $s 792093
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 30 $c 24 $d 3515-3518 $i 1873-2518 $m Vaccine $n Vaccine $x MED00004631
LZP    __
$b NLK122 $a Pubmed-20121023

Najít záznam

Citační ukazatele

Možnosti archivace