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Default mode network and extrastriate visual resting state network in patients with Parkinson's disease dementia
I. Rektorova, L. Krajcovicova, R. Marecek, M. Mikl
Language English Country Switzerland
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 2004-04-01 to 2015-11-30
Medline Complete (EBSCOhost)
from 2005-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 2004-04-01 to 2015-11-30
Health & Medicine (ProQuest)
from 2004-04-01 to 2015-11-30
Family Health Database (ProQuest)
from 2004-04-01 to 2015-11-30
Psychology Database (ProQuest)
from 2004-04-01 to 2015-11-30
PubMed
22269223
DOI
10.1159/000334765
Knihovny.cz E-resources
- MeSH
- Dementia complications pathology MeSH
- Adult MeSH
- Oxygen blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain Mapping MeSH
- Neuropsychological Tests MeSH
- Rest MeSH
- Parkinson Disease complications pathology MeSH
- Image Processing, Computer-Assisted MeSH
- Recognition, Psychology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Statistics as Topic MeSH
- Photic Stimulation MeSH
- Occipital Lobe blood supply physiopathology MeSH
- Visual Pathways blood supply physiopathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
AIMS: Using fMRI, we evaluated the default mode network (DMN) and the extrastriate visual resting state network (ESV-RSN) in 14 patients with Parkinson's disease dementia (PDD) as compared with 18 patients with Parkinson's disease (PD) without dementia and 18 healthy controls (HC). METHODS: We analyzed the seed-based functional connectivity of both resting state data and deactivations during a visual complex scene-encoding task. RESULTS: Using the posterior cingulate cortex/precuneus as a seed for the DMN analysis, we observed significant decreases of connectivity in the right inferior frontal gyrus in PDD as compared to PD and HC. Using the caudate nucleus as a seed for the ESV-RSN analysis, we found significant decreases of connectivity in the left and right inferior occipital gyrus in PDD as compared to HC. CONCLUSION: Differences in functional connectivity patterns between PDD and PD/HC were observed in areas known to be engaged in stimulus-driven reorienting of attention and in visual processing.
References provided by Crossref.org
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