• Je něco špatně v tomto záznamu ?

Interaction of aromatic cytokinins with human liver microsomal cytochromes P450

E. Anzenbacherová, J. Janalík, I. Popa, M. Strnad, P. Anzenbacher

. 2005 ; 149 (2) : 349-351.

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc13003742

Aromatic cytokinins (ortho-topolin riboside, 6-benzylaminopurine riboside and 6-(2-hydroxy-3-methoxybenzyla mino)purine riboside) were tested for their possible interaction with human liver microsomal cytochromes P450 by absorption difference spectroscopy. All three compounds were shown to bind to the CYP enzymes producing a high to low spin shift of the heme iron yielding a Soret absorption band shift to approximately 425 nm. As this type of spectral change means that the substance is able to bind directly to the heme iron, the results obtained open the possibility of an interaction of these compounds with metabolism of other drugs or, in general, with other substrates of cytochromes P450.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13003742
003      
CZ-PrNML
005      
20130301150749.0
007      
ta
008      
130128s2005 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2005.056 $2 doi
035    __
$a (PubMed)16601786
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Anzenbacherová, Eva, $d 1959- $7 stk2008428613 $u Institute of Medical Chemistry and Biochemistry, Palacky University, Olomouc
245    10
$a Interaction of aromatic cytokinins with human liver microsomal cytochromes P450 / $c E. Anzenbacherová, J. Janalík, I. Popa, M. Strnad, P. Anzenbacher
520    9_
$a Aromatic cytokinins (ortho-topolin riboside, 6-benzylaminopurine riboside and 6-(2-hydroxy-3-methoxybenzyla mino)purine riboside) were tested for their possible interaction with human liver microsomal cytochromes P450 by absorption difference spectroscopy. All three compounds were shown to bind to the CYP enzymes producing a high to low spin shift of the heme iron yielding a Soret absorption band shift to approximately 425 nm. As this type of spectral change means that the substance is able to bind directly to the heme iron, the results obtained open the possibility of an interaction of these compounds with metabolism of other drugs or, in general, with other substrates of cytochromes P450.
650    _2
$a systém (enzymů) cytochromů P-450 $x chemie $7 D003577
650    _2
$a cytokininy $x chemie $x farmakologie $7 D003583
650    _2
$a lidé $7 D006801
650    _2
$a jaterní mikrozomy $x enzymologie $7 D008862
650    _2
$a regulátory růstu rostlin $x chemie $x farmakologie $7 D010937
650    _2
$a spektrální analýza $7 D013057
655    _2
$a časopisecké články $7 D016428
700    1#
$a Janalík, Jakub. $7 _AN071557 $u Institute of Medical Chemistry and Biochemistry, Palacky University, Olomouc; Laboratory of Growth Regulators, Palacky University and Institute of Experimental Botany, Academy of Sciences Joint Laboratory, Olomouc
700    1_
$a Popa, Igor $7 jo2012690165 $u Laboratory of Growth Regulators, Palacky University and Institute of Experimental Botany, Academy of Sciences Joint Laboratory, Olomouc
700    1_
$a Strnad, Miroslav, $d 1958- $7 jn20010309068 $u Laboratory of Growth Regulators, Palacky University and Institute of Experimental Botany, Academy of Sciences Joint Laboratory, Olomouc
700    1_
$a Anzenbacher, Pavel, $d 1947- $7 xx0034447 $u Institute of Pharmacology, Faculty of Medicine, Palacky University, Olomouc
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic $x 1213-8118 $g Roč. 149, č. 2 (2005), s. 349-351
910    __
$a ABA008 $b A 1502 $c sign $y 3 $z 0
990    __
$a 20130128 $b ABA008
991    __
$a 20130301150951 $b ABA008
999    __
$a ok $b bmc $g 966398 $s 801937
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2005 $b 149 $c 2 $d 349-351 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK111 $a Pubmed-20130128

Najít záznam

Citační ukazatele

Možnosti archivace