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Možnosti využití huperzinu A v léčbě Alzheimerovy nemoci
[Potentials of huperzine A use in Alzheimer disease treatment]
Lucie Drtinová a Miroslav Pohanka
Language Czech Country Czech Republic
Document type Research Support, Non-U.S. Gov't
- MeSH
- Acetylcholinesterase MeSH
- Alzheimer Disease * drug therapy physiopathology MeSH
- Plaque, Amyloid MeSH
- Administration, Oral MeSH
- Cholinesterase Inhibitors * MeSH
- Haplorhini MeSH
- Huperzia * MeSH
- Clinical Trials, Phase I as Topic MeSH
- Drugs, Chinese Herbal * administration & dosage pharmacology isolation & purification therapeutic use MeSH
- Humans MeSH
- Neurodegenerative Diseases epidemiology drug therapy MeSH
- Drug Evaluation, Preclinical * methods MeSH
- Receptors, N-Methyl-D-Aspartate antagonists & inhibitors MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Aged MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Huperzine A, a mixture of compounds suitable for pharmaceutical purposes, has been used as an active substance in traditional Chinese medicine. The compounds mainly rank among lycopodin alkaloids from the plant Huperzia serrata and other plants from the families Huperziaceae and Lycopodiaceae and the Selaginella genus. In these families huperzine A prevails. The compounds are suitable for treatment of the Alzheimer disease (AD) by inhibition of acetylcholinesterase and antagonizing NMDA N-methyl-D-aspartate receptors. Currently clinical tests of huperzine A in the AD treatment are performed. The aim of the present review is to summarize basic facts about huperzine A compounds and discuss their suitability for the therapy.
Potentials of huperzine A use in Alzheimer disease treatment
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