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Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs
V. Vobruba, OV. Klimenko, J. Kobr, O. Cerna, P. Pokorna, I. Mikula, J. Hridel, O. Brantova, P. Martasek,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Medline Complete (EBSCOhost)
from 1999-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1980
- MeSH
- Acute Lung Injury etiology metabolism MeSH
- Bronchoalveolar Lavage Fluid chemistry cytology MeSH
- Chemokine CCL4 metabolism MeSH
- Cytokines metabolism MeSH
- Tidal Volume MeSH
- Nitrates metabolism MeSH
- Nitrites metabolism MeSH
- Interleukin-8 metabolism MeSH
- Lung metabolism pathology physiopathology MeSH
- Pulmonary Alveoli metabolism pathology MeSH
- Lung Compliance physiology MeSH
- Swine MeSH
- Nitric Oxide Synthase Type II metabolism MeSH
- Tumor Necrosis Factor-alpha metabolism MeSH
- Respiration, Artificial adverse effects MeSH
- Positive-Pressure Respiration instrumentation MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-α, MIP-1β, nitrites/nitrates, and inducible nitric oxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-α increased significantly in group III during the second and third hour (P = .01). Concentration of MIP-1β was significantly increased in groups II and III after the first hour (P = .012 and P = .008, respectively).
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