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The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli

PM Dougherty, J Palecek, V Paleckova, LS Sorkin, WD Willis

. 1992 ; 12 (8) : 3025-3041.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu práce podpořená grantem, Research Support, U.S. Gov't, P.H.S.

Perzistentní odkaz   https://www.medvik.cz/link/bmc13038434

Grantová podpora
PL146 MZ0 CEP - Centrální evidence projektů

Digitální knihovna NLK
Plný text - Část
Zdroj

E-zdroje Online Plný text

NLK Free Medical Journals od 1981 do Před 6 měsíci
PubMed Central od 1981 do Před 6 měsíci
Europe PubMed Central od 1981 do Před 6 měsíci
Open Access Digital Library od 1981-01-01
Open Access Digital Library od 1981-01-01

Odkazy

PubMed 1353793
Knihovny.cz E-zdroje

The role of excitatory amino acids (EAAs) in the excitation of monkey spinothalamic tract (STT) neurons following activation of cutaneous primary afferent fibers by noxious and non-noxious stimuli was investigated. The responses of STT neurons to either NMDA or non-NMDA EAA ligands were blocked by infusion of specific antagonists through a microdialysis fiber into the region surrounding the cells. Our results show that blockade of non-NMDA receptors results in a nearly complete elimination of the responses of STT neurons to all stimuli. Blockade of NMDA receptors results in an attenuation of the responses to noxious stimuli but, in addition, prevents the development of the sensitization of STT neurons that is often observed after intradermal injection of capsaicin. These observations further support a role of EAAs in the transmission of sensory information from primary afferent fibers to dorsal horn neurons and a role for NMDA receptors in the generation of hyperalgesia.

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