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Pharmacogenetics of chronic pain and its treatment
S. Světlík, K. Hronová, H. Bakhouche, O. Matoušková, O. Slanař,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NT11324
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
Directory of Open Access Journals
od 1992
Free Medical Journals
od 1992
PubMed Central
od 1992
Europe PubMed Central
od 1992
Open Access Digital Library
od 1992-01-01
Open Access Digital Library
od 1992-01-01
Open Access Digital Library
od 1992-01-01
Medline Complete (EBSCOhost)
od 1997-02-01
Wiley-Blackwell Open Access Titles
od 1992
ROAD: Directory of Open Access Scholarly Resources
od 1992
PubMed
23766564
DOI
10.1155/2013/864319
Knihovny.cz E-zdroje
- MeSH
- biologické markery krev MeSH
- chronická bolest krev genetika MeSH
- cytokiny metabolismus MeSH
- farmakogenetika metody MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers.
Institute of Pharmacology 1st Faculty of Medicine Charles University of Prague Prague Czech Republic
Citace poskytuje Crossref.org
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