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Utilization of cone beam CT for reconstruction of dose distribution delivered in image-guided radiotherapy of prostate carcinoma - bony landmark setup compared to fiducial markers setup
P. Paluska, J. Hanus, J. Sefrova, L. Rouskova, J. Grepl, J. Jansa, L. Kasaova, M. Hodek, M. Zouhar, M. Vosmik, J. Petera,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2000
Free Medical Journals
od 2000
Open Journal Systems (OJS)
od 2004
PubMed Central
od 2000
Europe PubMed Central
od 2000
ProQuest Central
od 2000-03-01
Health & Medicine (ProQuest)
od 2000-03-01
Wiley-Blackwell Open Access Titles
od 2000
ROAD: Directory of Open Access Scholarly Resources
od 2000
PubMed
23652250
DOI
10.1120/jacmp.v14i3.4203
Knihovny.cz E-zdroje
- MeSH
- adenokarcinom radioterapie MeSH
- celková dávka radioterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory prostaty radioterapie MeSH
- plánování radioterapie pomocí počítače MeSH
- počítačová tomografie s kuželovým svazkem využití MeSH
- radioterapie řízená obrazem * MeSH
- senioři MeSH
- staging nádorů MeSH
- zaměřovací značky pro radioterapii * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The purpose of this study was to compare two different styles of prostate IGRT: bony landmark (BL) setup vs. fiducial markers (FM) setup. Twenty-nine prostate patients were treated with daily BL setup and 30 patients with daily FM setup. Delivered dose distribution was reconstructed on cone-beam CT (CBCT) acquired once a week immediately after the alignment. Target dose coverage was evaluated by the proportion of the CTV encompassed by the 95% isodose. Original plans employed 1 cm safety margin. Alternative plans assuming smaller 7 mm margin between CTV and PTV were evaluated in the same way. Rectal and bladder volumes were compared with initial ones. While the margin reduction in case of BL setup makes the prostate coverage significantly worse (p = 0.0003, McNemar's test), in case of FM setup with the reduced 7 mm margin, the prostate coverage is even better compared to BL setup with 10 mm margin (p = 0.049, Fisher's exact test). Moreover, partial volumes of organs at risk irradiated with a specific dose can be significantly lowered (p < 0.0001, unpaired t-test). Reducing of safety margin is not acceptable in case of BL setup, while the margin can be lowered from 10 mm to 7 mm in case of FM setup.
Citace poskytuje Crossref.org
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