-
Je něco špatně v tomto záznamu ?
Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection
F. Mrazek, J. Gallo, A. Stahelova, M. Petrek,
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 2002-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2002-01-01 do Před 1 rokem
- MeSH
- artroplastika MeSH
- infekce spojené s protézou genetika MeSH
- infekce MeSH
- jednonukleotidový polymorfismus MeSH
- klouby chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- protézy a implantáty škodlivé účinky MeSH
- senioři MeSH
- stafylokokové infekce genetika MeSH
- Staphylococcus MeSH
- toll-like receptor 2 genetika MeSH
- toll-like receptor 4 genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVE AND DESIGN: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI. SUBJECTS AND METHODS: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphisms of the genes encoding for TLR2 (TLR2 R753Q, rs5743708) and TLR4 (TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by "TaqMan" assay. RESULTS: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/healthy individuals. CONCLUSION: Our data suggest that structural genetic variants of the receptors TLR2 and TLR4 do not substantially affect the risk of prosthetic joint infection.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc14040927
- 003
- CZ-PrNML
- 005
- 20140113120911.0
- 007
- ta
- 008
- 140107s2013 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00011-013-0601-8 $2 doi
- 035 __
- $a (PubMed)23417289
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Mrazek, Frantisek
- 245 10
- $a Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection / $c F. Mrazek, J. Gallo, A. Stahelova, M. Petrek,
- 520 9_
- $a OBJECTIVE AND DESIGN: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI. SUBJECTS AND METHODS: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphisms of the genes encoding for TLR2 (TLR2 R753Q, rs5743708) and TLR4 (TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by "TaqMan" assay. RESULTS: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/healthy individuals. CONCLUSION: Our data suggest that structural genetic variants of the receptors TLR2 and TLR4 do not substantially affect the risk of prosthetic joint infection.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a artroplastika $7 D001178
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a infekce $7 D007239
- 650 _2
- $a klouby $x chirurgie $7 D007596
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a jednonukleotidový polymorfismus $7 D020641
- 650 _2
- $a protézy a implantáty $x škodlivé účinky $7 D019736
- 650 _2
- $a infekce spojené s protézou $x genetika $7 D016459
- 650 _2
- $a stafylokokové infekce $x genetika $7 D013203
- 650 _2
- $a Staphylococcus $7 D013210
- 650 _2
- $a toll-like receptor 2 $x genetika $7 D051195
- 650 _2
- $a toll-like receptor 4 $x genetika $7 D051197
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Gallo, Jiri $u -
- 700 1_
- $a Stahelova, Anna $u -
- 700 1_
- $a Petrek, Martin $u -
- 773 0_
- $w MED00002242 $t Inflammation research : official journal of the European Histamine Research Society ... [et al.] $x 1420-908X $g Roč. 62, č. 5 (2013), s. 483-7
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/23417289 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20140107 $b ABA008
- 991 __
- $a 20140113121614 $b ABA008
- 999 __
- $a ok $b bmc $g 1005323 $s 839439
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2013 $b 62 $c 5 $d 483-7 $i 1420-908X $m Inflammation research $n Inflamm Res $x MED00002242
- LZP __
- $a Pubmed-20140107
