Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

New non-linear color look-up table for visualization of brain fractional anisotropy based on normative measurements - principals and first clinical use

Jiří Keller, Aaron M. Rulseh, Arnošt Komárek, Iva Latnerová, Robert Rusina, Hana Brožová, Josef Vymazal

. 2013 ; 8 (8) : e71431.

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc14063997

Grant support
NT11328 MZ0 CEP Register
NT12094 MZ0 CEP Register

Fractional anisotropy (FA) is the most commonly used quantitative measure of diffusion in the brain. Changes in FA have been reported in many neurological disorders, but the implementation of diffusion tensor imaging (DTI) in daily clinical practice remains challenging. We propose a novel color look-up table (LUT) based on normative data as a tool for screening FA changes. FA was calculated for 76 healthy volunteers using 12 motion-probing gradient directions (MPG), a subset of 59 subjects was additionally scanned using 30 MPG. Population means and 95% prediction intervals for FA in the corpus callosum, frontal gray matter, thalamus and basal ganglia were used to create the LUT. Unique colors were assigned to inflection points with continuous ramps between them. Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects. Four blinded radiologists classified subjects as MSA/non-MSA. Using only the LUT, high sensitivity (80%) and specificity (84%) were achieved in differentiating MSA subjects from PD subjects and controls. The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc14063997
003      
CZ-PrNML
005      
20181017152151.0
007      
ta
008      
140704s2013 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1371/journal.pone.0071431 $2 doi
035    __
$a (PubMed)23990954
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Keller, Jiří, $u Department of Neurology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; Department of Radiology, Na Homolce Hospital, Prague, Czech Republic $d 1981- $7 xx0145264
245    10
$a New non-linear color look-up table for visualization of brain fractional anisotropy based on normative measurements - principals and first clinical use / $c Jiří Keller, Aaron M. Rulseh, Arnošt Komárek, Iva Latnerová, Robert Rusina, Hana Brožová, Josef Vymazal
520    9_
$a Fractional anisotropy (FA) is the most commonly used quantitative measure of diffusion in the brain. Changes in FA have been reported in many neurological disorders, but the implementation of diffusion tensor imaging (DTI) in daily clinical practice remains challenging. We propose a novel color look-up table (LUT) based on normative data as a tool for screening FA changes. FA was calculated for 76 healthy volunteers using 12 motion-probing gradient directions (MPG), a subset of 59 subjects was additionally scanned using 30 MPG. Population means and 95% prediction intervals for FA in the corpus callosum, frontal gray matter, thalamus and basal ganglia were used to create the LUT. Unique colors were assigned to inflection points with continuous ramps between them. Clinical use was demonstrated on 17 multiple system atrophy (MSA) patients compared to 13 patients with Parkinson disease (PD) and 17 healthy subjects. Four blinded radiologists classified subjects as MSA/non-MSA. Using only the LUT, high sensitivity (80%) and specificity (84%) were achieved in differentiating MSA subjects from PD subjects and controls. The LUTs generated from 12 and 30 MPG were comparable and accentuate FA abnormalities.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a algoritmy $7 D000465
650    12
$a anizotropie $7 D016880
650    _2
$a bazální ganglia $x fyziologie $7 D001479
650    _2
$a mozek $x fyziologie $7 D001921
650    _2
$a mapování mozku $x metody $7 D001931
650    12
$a barva $7 D003116
650    _2
$a corpus callosum $x fyziologie $7 D003337
650    _2
$a zobrazování difuzních tenzorů $x metody $7 D056324
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a čelní lalok $x fyziologie $7 D005625
650    _2
$a zdraví dobrovolníci pro lékařské studie $7 D064368
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a multisystémová atrofie $x diagnóza $x patologie $7 D019578
650    _2
$a Parkinsonova nemoc $x diagnóza $x patologie $7 D010300
650    _2
$a referenční hodnoty $7 D012016
650    _2
$a senzitivita a specificita $7 D012680
650    _2
$a poměr signál - šum $7 D059629
650    _2
$a software $7 D012984
650    _2
$a thalamus $x fyziologie $7 D013788
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Rulseh, Aaron Michael $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic $7 xx0243723
700    1_
$a Komárek, Arnošt $u Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University in Prague, Prague, Czech Republic $7 mzk2008434100
700    1_
$a Latnerová, Iva $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic
700    1_
$a Rusina, Robert, $u Department of Neurology, Thomayer Hospital, Prague, Czech Republic; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Prague, Czech Republic $d 1969- $7 mzk2007386024
700    1_
$a Brožová, Hana, $u Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Prague, Czech Republic $d 1974- $7 mzk2007381799
700    1_
$a Vymazal, Josef, $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic $d 1962- $7 xx0066412
773    0_
$w MED00180950 $t PloS one $x 1932-6203 $g Roč. 8, č. 8 (2013), s. e71431
856    41
$u https://pubmed.ncbi.nlm.nih.gov/23990954 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20140704 $b ABA008
991    __
$a 20181017152650 $b ABA008
999    __
$a ok $b bmc $g 1031481 $s 862729
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2013 $b 8 $c 8 $d e71431 $i 1932-6203 $m PLoS One $n PLoS One $x MED00180950
GRA    __
$a NT11328 $p MZ0
GRA    __
$a NT12094 $p MZ0
LZP    __
$a Pubmed-20140704

Find record

Citation metrics

Archiving options