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Lower omega-3 index is a marker of increased propensity of hypertensive rat heart to malignant arrhythmias
B. Bačová, P. Seč, J. Radošinská, M. Čertík, A. Vachulová, N. Tribulová
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 1991
Free Medical Journals
od 1998
ProQuest Central
od 2005-01-01
Medline Complete (EBSCOhost)
od 2006-01-01
Nursing & Allied Health Database (ProQuest)
od 2005-01-01
Health & Medicine (ProQuest)
od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1998
- MeSH
- biologické markery krev MeSH
- dietní tuky nenasycené krev farmakokinetika MeSH
- hypertenze krev komplikace MeSH
- krevní tlak MeSH
- krysa rodu rattus MeSH
- kyseliny mastné omega-3 krev MeSH
- potkani inbrední SHR MeSH
- potkani Wistar MeSH
- prognóza MeSH
- reprodukovatelnost výsledků MeSH
- rizikové faktory MeSH
- senzitivita a specificita MeSH
- srdeční arytmie krev etiologie MeSH
- srdeční frekvence MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Polyunsaturated omega-3 fatty acids (omega-3 PUFA) are important components of cell membrane affecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to life-threatening arrhythmias that are reduced by omega-3 PUFA intake. Purpose of this study was to explore plasma and red blood cells (RBC) profile of omega-3 and omega-6 PUFA as well as to determine omega-3 index, a risk factor for sudden cardiac death, in aged SHR and the effect of omega-3 PUFA intake. Male and female 12-month-old SHR and age-matched Wistar rats fed with omega-3 PUFA (200 mg/kg BW/day/2 month) were compared with untreated rats. Composition of omega-3 PUFA: alpha linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as omega-6 PUFA: linoleic acid and arachidonic acid was analyzed by gas chromatography. Results showed sex- and strain-related differences of basal omega-3 and omega-6 PUFA levels in plasma and RBC as well as in response to omega-3 PUFA intake. Comparing to Wistar rats omega-3 index, expressed as a percentage of EPA+DHA of total fatty acids, was lower in SHR and it increased due to consumption of omega-3 PUFA. Findings support our hypothesis that lower omega-3 index may be also a marker of increased propensity of the hypertensive rat heart to malignant arrhythmias.
Department of Arrhythmias National Cardiovascular Institute Bratislava Slovakia
Faculty of Chemical and Food Technology Slovak University of Technology Bratislava Slovakia
Institute for Heart Research Slovak Academy of Sciences Bratislava Slovakia
Institute of Biochemistry and Genetic of Animals Slovak Academy of Sciences Bratislava Slovakia
Institute of Physiology Medical Faculty of Comenius University Bratislava Slovakia
Citace poskytuje Crossref.org
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